Circoviridae

VIRION

Non-enveloped, round, T=1 icosahedral symmetry, about 20 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.

GENOME

Monopartite, circular, ssDNA genome of about 1.8 to 3.8 kb.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates rolling circle replication.

GENE EXPRESSION

One or two mRNAs encode for the Rep, capsid, and possibly others proteins. Some mRNA can undergo alternative splicing.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

Autophagy modulation

Cap protein of PCV2 induces activation of host autophagy in order to enhance its own replication .

Apoptosis modulation

PCV2 ORF3-encoded protein induces apoptosis by activating caspase-8 and caspase-3 pathways . This protein may be a candidate for PML bodies inhibition which is essential for nuclear virus replication in mammals.

Matching UniProtKB/Swiss-Prot entries

27 entries grouped by protein (browse by keywords)

7 entries

Capsid protein

Select_allDeselect_all
CAPSD_CACV
Canary circovirus (CaCV) reference strain

Probable capsid protein

CAPSD_HCYV5
Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007) (HuCyV-1) (Cyclovirus PK5510) reference strain
CAPSD_PCV1C
Porcine circovirus 1 (isolate China) (PCV1) reference strain
CAPSD_PICV
Pigeon circovirus (PiCV) (Columbid circovirus) reference strain

Probable capsid protein

CAPSD_BFDV
Beak and feather disease virus (BFDV)
CAPSD_GOCV
Goose circovirus (GoCV)

Probable capsid protein

CAPSD_PCV2
Porcine circovirus 2 (PCV2)

1 entry

Protein NS0

NS0_PCV2
Porcine circovirus 2 (PCV2)

2 entries

Protein ORF3

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ORF3_BFDV
Beak and feather disease virus (BFDV)

Uncharacterized protein ORF3

ORF3_PCV2
Porcine circovirus 2 (PCV2)

2 entries

Anti-apoptotic ORF4 protein

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ORF4_BFDV
Beak and feather disease virus (BFDV)

Uncharacterized protein ORF4

ORF4_PCV2
Porcine circovirus 2 (PCV2)

1 entry

Uncharacterized protein ORF5

ORF5_BFDV
Beak and feather disease virus (BFDV)

1 entry

Uncharacterized protein ORF6

ORF6_BFDV
Beak and feather disease virus (BFDV)

1 entry

Uncharacterized protein ORF7

ORF7_BFDV
Beak and feather disease virus (BFDV)

2 entries

Uncharacterized protein ORFC2

Select_allDeselect_all
ORFC2_PICV
Pigeon circovirus (PiCV) (Columbid circovirus) reference strain
ORFC2_GOCV
Goose circovirus (GoCV)

1 entry

Uncharacterized protein ORFC3

ORFC3_PICV
Pigeon circovirus (PiCV) (Columbid circovirus) reference strain

1 entry

Uncharacterized protein ORFC4

ORFC4_PICV
Pigeon circovirus (PiCV) (Columbid circovirus) reference strain

1 entry

Uncharacterized protein ORFV2

ORFV2_GOCV
Goose circovirus (GoCV)

7 entries

Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.3) (ATP-dependent helicase Rep) (RepP)

Select_allDeselect_all
REP_CACV
Canary circovirus (CaCV) reference strain
REP_HCYV5
Human associated cyclovirus 1 (isolate Homo sapiens/Pakistan/PK5510/2007) (HuCyV-1) (Cyclovirus PK5510) reference strain

Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.3) (ATP-dependent helicase Rep) (RepP)

REP_PCV1C
Porcine circovirus 1 (isolate China) (PCV1) reference strain

Replication-associated protein (Rep) (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.3) (ATP-dependent helicase Rep) (RepP)

REP_PICV
Pigeon circovirus (PiCV) (Columbid circovirus) reference strain
REP_BFDV
Beak and feather disease virus (BFDV)
REP_GOCV
Goose circovirus (GoCV)
REP_PCV2
Porcine circovirus 2 (PCV2)