Circoviridae (taxid:39724)
VIRION
Non-enveloped, round, T=1 icosahedral symmetry, about 20 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.
GENOME
Monopartite, circular, ssDNA genome of about 1.8 to 3.8 kb.
The genome is replicated through double-stranded intermediates. The replication (Rep) protein initiates rolling circle replication.
GENE EXPRESSION
One or two mRNAs encode for the Rep, capsid, and possibly others proteins. Some mRNA can undergo alternative splicing.
ENZYMES
REPLICATION
NUCLEAR
- Virus penetrates into the host cell.
- Uncoating, the viral ssDNA genome penetrates into the nucleus.
- Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
- Viral mRNAs are translated to produce viral proteins.
- Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
- These newly synthesized ssDNA can either
a) be converted to dsDNA and serve as a template for transcription/replication
b) be encapsidated by capsid protein and form virions released by cell lysis.
Host-virus interaction
Autophagy modulation
Cap protein of PCV2 induces activation of host autophagy in order to enhance its own replication
.
Apoptosis modulation
PCV2 ORF3-encoded protein induces apoptosis by activating caspase-8 and caspase-3 pathways
. This protein may be a candidate for PML bodies inhibition which is essential for nuclear virus replication in mammals.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)27 entries grouped by protein
7 entries
Capsid protein
1 entry
Protein NS0
2 entries
Protein ORF3
2 entries
Anti-apoptotic ORF4 protein
1 entry
Uncharacterized protein ORF5
1 entry
Uncharacterized protein ORF6
1 entry
Uncharacterized protein ORF7
2 entries
Uncharacterized protein ORFC2
1 entry
Uncharacterized protein ORFC3
1 entry
Uncharacterized protein ORFC4
1 entry
Uncharacterized protein ORFV2
7 entries
Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep) (RepP)
Acartia tonsa copepod circovirus taxid:1168547
| Protein | ModelArchive |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20901 |
| Uncharacterized protein | ma-jd-viral-49947 |
Aiptasia sp. sea anemone associated circular virus taxid:1692242
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27282 |
| Putative replication initiation protein | ma-jd-viral-17086 |
Anguilla anguilla circovirus taxid:1420600
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-63316 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20702 |
Artemia melana sponge associated circular genome taxid:1692243
| Protein | ModelArchive |
| Putative spliced replication initiation protein | ma-jd-viral-20872 |
Avon-Heathcote Estuary associated circular virus 1 taxid:1618232
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28633 |
| Replication-associated protein | ma-jd-viral-20932 |
Avon-Heathcote Estuary associated circular virus 11 taxid:1618234
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-39165 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20965 |
Avon-Heathcote Estuary associated circular virus 12 taxid:1618235
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-41440 |
| Replication-associated protein | ma-jd-viral-20744 |
Avon-Heathcote Estuary associated circular virus 14 taxid:1618237
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28507 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20863 |
Avon-Heathcote Estuary associated circular virus 15 taxid:1618238
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27868 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20138 |
Avon-Heathcote Estuary associated circular virus 17 taxid:1618240
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28020 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20859 |
Avon-Heathcote Estuary associated circular virus 19 taxid:1618242
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-54884 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20818 |
Avon-Heathcote Estuary associated circular virus 20 taxid:1618244
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-30800 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20745 |
Avon-Heathcote Estuary associated circular virus 21 taxid:1618245
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28848 |
| Replication-associated protein | ma-jd-viral-20856 |
Avon-Heathcote Estuary associated circular virus 22 taxid:1618246
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-48218 |
| Replication-associated protein | ma-jd-viral-50674 |
Avon-Heathcote Estuary associated circular virus 23 taxid:1618247
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28653 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20755 |
Avon-Heathcote Estuary associated circular virus 26 taxid:1618250
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-63939 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20735 |
Avon-Heathcote Estuary associated circular virus 27 taxid:1618251
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27804 |
| Replication-associated protein | ma-jd-viral-17095 |
Avon-Heathcote Estuary associated circular virus 28 taxid:1618252
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-41560 |
| Replication-associated protein | ma-jd-viral-41439 |
Avon-Heathcote Estuary associated circular virus 29 taxid:1618253
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-56953 |
| Replication-associated protein | ma-jd-viral-50691 |
Avon-Heathcote Estuary associated circular virus 5 taxid:1618256
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27558 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20682 |
Avon-Heathcote Estuary associated circular virus 6 taxid:1618257
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-53457 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20795 |
Avon-Heathcote Estuary associated circular virus 7 taxid:1618258
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-55034 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20767 |
Avon-Heathcote Estuary associated circular virus 8 taxid:1618259
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-53120 |
| Replication-associated protein | ma-jd-viral-50675 |
Barbel circovirus taxid:759938
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27842 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20903 |
Bat circovirus POA/2012/VI taxid:1572239
| Protein | ModelArchive |
| Capsid | ma-jd-viral-27483 |
| Replicase | ma-jd-viral-17138 |
Calanoida sp. copepod associated circular virus taxid:1692244
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-08414 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20881 |
Callinectes ornatus blue crab associated circular virus taxid:1692245
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-38877 |
| Putative replication initiation protein | ma-jd-viral-17109 |
Callinectes sapidus associated circular virus taxid:1692246
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-60604 |
| Replication-associated protein | ma-jd-viral-20691 |
Canary circovirus taxid:142661
| Protein | ModelArchive |
| Probable capsid protein | ma-jd-viral-28754 |
| Replication-associated protein (EC 2.7.7.-) (EC 3.1.21.-) (EC 3.6.1.-) (ATP-dependent helicase Rep)... | ma-jd-viral-20927 |
Canine circovirus taxid:1194757
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27432 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20747 |
Chimpanzee faeces associated circular DNA virus 1 taxid:1676184
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-50905 |
| Putative CP | ma-jd-viral-55732 |
| Replication-associated protein | ma-jd-viral-33283 |
Cyclovirus NGchicken15/NGA/2009 taxid:942037
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-27174 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20740 |
Cyclovirus PKgoat11/PAK/2009 taxid:942034
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-27181 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20828 |
Cyclovirus PKgoat21/PAK/2009 taxid:942033
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-27171 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20716 |
Cyclovirus TsCyV-1_JP-NUBS-2014 taxid:1592764
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27192 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20807 |
Cyclovirus ZM36a taxid:1506568
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27187 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20672 |
Cyclovirus bat/USA/2009 taxid:942035
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-27184 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20851 |
Didemnum sp. Sea Squirt associated virus taxid:1692247
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28003 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20719 |
Dragonfly associated cyclovirus 1 taxid:1234879
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27188 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20940 |
Dragonfly associated cyclovirus 3 taxid:1234881
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27170 |
| Replication-associated protein | ma-jd-viral-20785 |
| Spliced replication-associated protein | ma-jd-viral-20936 |
Dragonfly associated cyclovirus 5 taxid:1234883
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27165 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20817 |
Dragonfly cyclovirus 2 taxid:1234880
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28875 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20804 |
Duck circovirus taxid:324685
Farfantepenaeus duorarum pink shrimp associated circular virus taxid:1692248
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27280 |
| Putative replication initiation protein | ma-jd-viral-20945 |
Feline cyclovirus taxid:1530454
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28014 |
| Replication-associated protein | ma-jd-viral-20853 |
Fiddler Crab associated circular virus taxid:1692249
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28652 |
| Putative replication initiation protein | ma-jd-viral-17115 |
Finch circovirus taxid:400122
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28761 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20866 |
| Uncharacterized protein | ma-jd-viral-58828 |
Fur seal faeces associated circular DNA virus taxid:1353241
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27905 |
| Replication-associated protein | ma-jd-viral-20968 |
Gammarus sp. amphipod associated circular virus taxid:1692250
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28018 |
| Putative replication initiation protein | ma-jd-viral-17096 |
Goose circovirus taxid:146032
Gull circovirus taxid:400121
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28760 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20763 |
| Uncharacterized protein | ma-jd-viral-29081 |
Hermit crab associated circular genome taxid:1692251
| Protein | ModelArchive |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20673 |
Hermit crab associated circular virus taxid:1692252
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27964 |
| Putative replication initiation protein | ma-jd-viral-17087 |
Human cyclovirus taxid:1455626
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28874 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20835 |
Human cyclovirus VS5700009 taxid:1345637
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27190 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20890 |
Indian encephalitis associated cyclovirus taxid:1755290
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-27182 |
| Replication-associated protein | ma-jd-viral-20704 |
Labidocera aestiva circovirus taxid:1173709
| Protein | ModelArchive |
| Putative structural protein | ma-jd-viral-43922 |
| Putative viral replication protein | ma-jd-viral-20727 |
Littorina sp. associated circular virus taxid:1692253
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-48878 |
| Putative replication initiation protein | ma-jd-viral-17125 |
Lytechinus variegatus variable sea urchin associated circular virus taxid:1692254
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28769 |
| Putative replication initiation protein | ma-jd-viral-17051 |
Marine snail associated circular virus taxid:1692255
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27963 |
| Putative replication initiation protein | ma-jd-viral-17134 |
Mink circovirus taxid:1475143
| Protein | ModelArchive |
| Cap protein (Capsid protein) | ma-jd-viral-27514 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20734 |
Mosquito circovirus taxid:1611039
| Protein | ModelArchive |
| Capsid | ma-jd-viral-64631 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20752 |
Mytilus sp. clam associated circular virus taxid:1692256
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27281 |
| Putative replication initiation protein | ma-jd-viral-17060 |
Palaemonetes intermedius brackish grass shrimp associated circular virus taxid:1692257
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27962 |
| Putative replication initiation protein | ma-jd-viral-17126 |
Palaemonetes kadiakensis Mississippi grass shrimp associated circular virus taxid:1692258
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-36122 |
| Replication-associated protein | ma-jd-viral-20769 |
Palaemonetes sp. common grass shrimp associated circular virus taxid:1692259
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-53458 |
| Putative replication initiation protein | ma-jd-viral-17089 |
Paramuricea placomus associated circular virus taxid:1692260
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-56688 |
| Putative replication initiation protein | ma-jd-viral-16981 |
Penaeus monodon circovirus VN11 taxid:1419711
| Protein | ModelArchive |
| Nonstructural protein 2 | ma-jd-viral-33106 |
| Replication-associated protein | ma-jd-viral-20894 |
| Structural protein VP | ma-jd-viral-28530 |
Petrochirus diogenes giant hermit crab associated circular virus taxid:1692261
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-33198 |
| Putative replication initiation protein | ma-jd-viral-20826 |
Pigeon circovirus taxid:126070
Po-Circo-like virus 21 taxid:1105383
Porcine circovirus 3 taxid:1868221
| Protein | ModelArchive |
| Cap | ma-jd-viral-27790 |
| Cap (Capsid) | ma-jd-viral-27790 |
Porcine circovirus type 1/2a taxid:720569
| Protein | ModelArchive |
| Capsid | ma-jd-viral-27508 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20701 |
Porcine stool-associated circular virus 4 taxid:1475062
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-27902 |
| Replication-associated protein | ma-jd-viral-20966 |
Porcine stool-associated circular virus 5 taxid:1475063
| Protein | ModelArchive |
| Cap protein | ma-jd-viral-57412 |
| Replication-associated protein | ma-jd-viral-20885 |
Primnoa pacifica coral associated circular virus taxid:1692262
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-34280 |
| Replication-associated protein | ma-jd-viral-20137 |
Raven circovirus taxid:345250
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28759 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20758 |
Sicyonia brevirostris associated circular virus taxid:1692263
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-27882 |
| Putative replication initiation protein | ma-jd-viral-38092 |
Starling circovirus taxid:349370
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28753 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20809 |
| Uncharacterized protein | ma-jd-viral-39523 |
Swan circovirus taxid:459957
| Protein | ModelArchive |
| Putative capsid protein | ma-jd-viral-28850 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20771 |
Zebra finch circovirus taxid:1642515
| Protein | ModelArchive |
| Capsid protein | ma-jd-viral-28756 |
| ORFC2 | ma-jd-viral-29717 |
| ORFV2 | ma-jd-viral-42535 |
| Replication-associated protein (ATP-dependent helicase Rep) (RepP) | ma-jd-viral-20778 |