Myoviridae

VIRION

Non-enveloped, head-tail structure. The tail is contractile.

GENOME

Linear, dsDNA genome of about 33-244 kb, encoding for 40-415 proteins, the peduoviruses being the smallest ones. Some species have a linear, circularly permuted genome.

GENE EXPRESSION

Genes are transcribed by operons.

REPLICATION

CYTOPLASMIC

  1. Adsorption: the phage attaches to the target cell through its tail fibers.
  2. Viral exolysin degrades cell wall locally
  3. Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
  4. Transcription and translation of early genes.
  5. Replication of genomic DNA. Transcription and translation of late genes.
  6. Assembly of an empty procapsid and packaging of the genome.
  7. Viral tail fibers assembly and viral tail assembly.
  8. Mature virions are released from the cell by lysis.