Leporipoxvirus

VIRION

Enveloped, brick-shaped 300x250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 160kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Myxoma virus strain Lausanne genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules .

Apoptosis modulation

Myxoma virus M11L inhibits host apoptosis by preventing the conformational activation of host Bax at the mitochondria .

Cell-cycle modulation

The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .

Matching UniProtKB/Swiss-Prot entries

59 entries grouped by strain (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

27 entries

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

Select_allDeselect_all
B14_RFVKA Protein B14 homolog (Protein T3A)
RP07_RFVKA DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
PAP1_RFVKA Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
MP44_RFVKA Probable metalloendopeptidase G1-type (EC 3.4.24.-)
MCEL_RFVKA mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) ...
NPH2_RFVKA RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
LAP_RFVKA E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
NTP1_RFVKA Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
D2_RFVKA Core protein D4
D3_RFVKA Core protein D3 homolog (27 kDa virion core protein)
D10_RFVKA mRNA-decapping protein D10 (EC 3.1.3.-)
D9_RFVKA mRNA-decapping protein D9 (EC 3.1.3.-)
A18_RFVKA Transcript termination protein A18 (EC 3.6.4.-)
A28_RFVKA Envelope protein A28 homolog (Protein Gp116)
KITH_RFVKA Thymidine kinase (EC 2.7.1.21)
GRFA_RFVKA Growth factor (Secreted epidermal growth factor-like)
ETF1_RFVKA Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
ETF2_RFVKA Early transcription factor 82 kDa subunit (ETF large subunit)
VT4_RFVKA T4 protein
VT5_RFVKA Ankyrin repeat protein T5
VT1_RFVKA Protein T1
VT2_RFVKA Tumor necrosis factor soluble receptor (Protein T2)
TOP1_RFVKA DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)
VH21_RFVKA Probable host range protein 2-1
UNG_RFVKA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
VH22_RFVKA Probable host range protein 2-2
VH23_RFVKA Probable host range protein 2-3

25 entries

Myxoma virus (strain Lausanne) (MYXV) reference strain

Select_allDeselect_all
RP07_MYXVL DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
RP22_MYXVL DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
KITH_MYXVL Thymidine kinase (EC 2.7.1.21)
PAP1_MYXVL Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
MT5_MYXVL Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
NPH2_MYXVL RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
LAP_MYXVL E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
MCE_MYXVL Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
NTP1_MYXVL Nucleoside triphosphatase I (EC 3.6.1.15) (M86L protein) (NPH-I) (Nucleoside triphosphate ...
MP44_MYXVL Probable metalloendopeptidase G1-type (EC 3.4.24.-)
A18_MYXVL Transcript termination protein A18 (EC 3.6.4.-)
A28_MYXVL Envelope protein A28 homolog (Protein M116)
GRFA_MYXVL Growth factor (Secreted epidermal growth factor-like)
ETF1_MYXVL Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
ETF2_MYXVL Early transcription factor 82 kDa subunit (ETF large subunit)
DUSP_MYXVL Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)
VH22_MYXVL Probable host range protein 2-2
VH23_MYXVL Probable host range protein 2-3
VT2_MYXVL Tumor necrosis factor soluble receptor (Protein T2)
SPI1_MYXVL Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)
SPI2_MYXVL Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
VMT9_MYXVL Kelch repeat protein M-T9 (M9-R polypeptide)
VMF7_MYXVL MF7 protein
VMT8_MYXVL Kelch repeat protein M-T8
VH21_MYXVL Probable host range protein 2-1

7 entries

Myxoma virus (strain Uriarra) (MYXV)

Select_allDeselect_all
RP22_MYXVU DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
SPI2_MYXVU Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
KITH_MYXVU Thymidine kinase (EC 2.7.1.21)
MCE_MYXVU Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
A28_MYXVU Envelope protein A28 homolog (MA28)
VH21_MYXVU Probable host range protein 2-1
VMF7_MYXVU MF7 protein