Orthoherpesviridae (taxid:3044472)
VIRION
Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embed in the lipid envelope.
GENOME
Monopartite, linear, dsDNA genome of 120-240 kb. The genome contains terminal and internal reiterated sequences.
GENE EXPRESSION
Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.
REPLICATION
NUCLEAR
Lytic replication:
- Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
- The capsid is transported to the nuclear pore where viral DNA is released into the nucleus.
- Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
- Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
- A first round of circular genome amplification occurs by bidirectional replication
- Synthesis of linear concatemer copies of viral DNA by rolling circle.
- Transcription of late mRNAs by host polymerase II, encoding structural proteins.
- Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.
Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.
Host-virus interaction
Adaptive immune response inhibition
Herpesviruses have evolved different strategies to inhibit the host adaptive immune response. For example, Herpes simplex protein US12 binds specifically to transporters associated with antigen processing (TAP), blocking peptide-binding to TAP and subsequent loading of peptides onto MHC class I molecules 
. HCMV instead encodes a protein termed US3 that directly binds and inhibits host tapasin.
Apoptosis modulation
Apoptosis is very often modulated (and usually inhibited) by herpesviridae. The mechanisms used can be caspase-dependent such as HCMV vICA that prevents host caspase-8 activation, or can involved the inhibition other cellular proteins involved in apoptosis such as EBV protein BHRF1, a viral homologue of the Bcl-2 that protect the infected cell against apoptosis.
Autophagy modulation
Several herpesvirus are able to inhibit host cell autophagy process , such as HHV-1 ICP34.5 that interacts with Beclin-1 and stop autophagosomes development.
Cell-cycle modulation
The UL24 protein that is present in all herpesvirus subfamilies ( alpha, beta and gamma-herpesviruses) induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .
Innate immune response inhibition
Herpes viruses inhibit the cascade leading to production of interferon-beta by mainly targeting the host IRF3 protein. Thus, herpes simplex virus, varicella virus, or HCMV all possess proteins to prevent IRF3 activation.
Host splicing inhibition
HSV-1 ICP27 is an alternative splicing regulator of host mRNA. This protein is conserved in several herpesviridae genera. It has been shown to act as a splicing silencer at the 3' splice site of the PML intron 7a .
Species
Synonyms
| 2016 naming | 1970's naming | Other common name |
|---|---|---|
| Human alphaherpesvirus 1 | Human herpesvirus 1 (HHV-1) | Herpes simplex virus 1 (HSV-1) |
| Human alphaherpesvirus 2 | Human herpesvirus 2 (HHV-2) | Herpes simplex virus 2 (HSV-2) |
| Human alphaherpesvirus 3 | Human herpesvirus 3 (HHV-3) | Varicella Zoster virus (VZV) |
| Human gammaherpesvirus 4 | Human herpesvirus 4 (HHV-4) | Epstein Barr virus (EBV) |
| Human betaherpesvirus 5 | Human herpesvirus 5 (HHV-5) | Human cytomegalovirus (HCMV) |
| Human betaherpesvirus 6A | Human herpesvirus 6A (HHV-6A) | |
| Human betaherpesvirus 6B | Human herpesvirus 6B (HHV-6B) | |
| Human betaherpesvirus 7 | Human herpesvirus 7 (HHV-7) | |
| Human gammaherpesvirus 8 | Human herpesvirus 8 (HHV-8) | Kaposi syndrome herpesvirus (KSHV) |
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)2065 entries grouped by protein
21 entries
Alkaline nuclease (EC 3.1.-.-)
2 entries
Apoptosis regulator Bcl-2 homolog
1 entry
Alpha trans-inducing factor (Tegument protein UL46) (Tegument protein VP11/12)
1 entry
Protein B1
1 entry
Protein B2
1 entry
Protein B3
1 entry
Protein B4
1 entry
Protein B5
1 entry
Protein B6
1 entry
Protein B7
1 entry
Protein B8
1 entry
Protein B9
2 entries
Apoptosis regulator BALF1
3 entries
Secreted protein BARF1 (33 kDa early protein) (p33)
3 entries
Protein BDLF2
1 entry
Glycoprotein BDLF3
1 entry
Late gene expression regulator BFRF2
1 entry
Uncharacterized protein BHLF1
1 entry
G-protein coupled receptor BILF1 (GPCR BILF1)
1 entry
Glycoprotein BILF2
3 entries
Tegument protein BKRF4
3 entries
Uncharacterized protein BLLF2
3 entries
Tegument protein BLRF2
3 entries
Protein BMRF2
3 entries
Protein BNLF2a
3 entries
Uncharacterized protein BNLF2b
1 entry
Replication and transcription activator (Rta) (Immediate-early protein Rta) (Protein R)
6 entries
Putative transcription activator BRLF1 homolog
3 entries
Transcriptional activator BRRF1
3 entries
Tegument protein BRRF2
3 entries
Uncharacterized protein BTRF1
3 entries
Lytic switch protein BZLF1 (EB1) (Protein Z) (Trans-activator protein BZLF1) (Zebra) (Zta) (bZIP transcription factor ZEBRA)
1 entry
Complement control protein homolog (CCPH)
2 entries
Putative CC-type chemokine U83
1 entry
Surface glycoprotein CD59 homolog
19 entries
Cytoplasmic envelopment protein 1
20 entries
Cytoplasmic envelopment protein 2
20 entries
Cytoplasmic envelopment protein 3
1 entry
Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
1 entry
Cyclin homolog (V-cyclin)
17 entries
Capsid vertex component 1
21 entries
Capsid vertex component 2
1 entry
Chemokine vCXCL1
29 entries
Major DNA-binding protein
31 entries
DNA polymerase catalytic subunit (EC 2.7.7.7)
2 entries
Uncharacterized protein DR1
1 entry
Uncharacterized protein DR2
2 entries
Uncharacterized protein DR3
1 entry
Uncharacterized protein DR4
1 entry
Uncharacterized protein DR5
2 entries
G2/M cell-cycle inhibitor DR6
1 entry
Transactivator protein DR7
1 entry
Uncharacterized protein DR8
23 entries
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
4 entries
Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)
3 entries
DNA polymerase processivity factor BMRF1 (Early Antigen Diffused) (EA-D) (Polymerase accessory subunit)
3 entries
Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
3 entries
Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1) (EC 3.1.21.-)
3 entries
Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
3 entries
Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A)
3 entries
Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) (EBNA-3B) (EBV nuclear antigen 3B)
3 entries
Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) (Epstein-Barr nuclear antigen 5) (EBNA-5) (EBV nuclear antigen 5)
3 entries
Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)
2 entries
Early phosphoprotein p84
12 entries
Envelope protein UL45 (18 kDa protein)
46 entries
Envelope glycoprotein B (gB)
18 entries
Envelope glycoprotein C
4 entries
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.148) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)
4 entries
Probable ganciclovir kinase (EC 2.7.1.-)
19 entries
Envelope glycoprotein D (gD)
14 entries
Envelope glycoprotein E (gE)
9 entries
Envelope glycoprotein G (gG)
35 entries
Envelope glycoprotein H (gH)
13 entries
Envelope glycoprotein I (gI)
2 entries
Envelope glycoprotein J
13 entries
Envelope glycoprotein K (Syncytial protein)
36 entries
Envelope glycoprotein L (gL)
22 entries
Envelope glycoprotein M (gM)
24 entries
Envelope glycoprotein N
6 entries
120 kDa Glycoprotein O (gO-120K) (Glycoprotein U47)
1 entry
Glycoprotein 105 (gp105)
3 entries
Glycoprotein gp2 (Glycoprotein X) (GpX)
3 entries
Envelope glycoprotein GP350 (Membrane antigen) (MA)
3 entries
Glycoprotein 42 (gp42)
2 entries
Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)
2 entries
Glycoprotein Q2 (gQ2)
18 entries
DNA replication helicase (EC 3.6.4.-)
17 entries
DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
7 entries
E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)
9 entries
Transcriptional regulator ICP22 homolog (IR4 protein) (Immediate-early protein IE68) (In vitro host-range factor) (ORF S1-2)
21 entries
mRNA export factor ICP27 homolog
5 entries
Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)
12 entries
Major viral transcription factor ICP4 homolog
5 entries
ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)
1 entry
Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)
3 entries
Immediate-early protein 2 (IE2)
1 entry
45 kDa immediate-early protein 2 (IE2)
2 entries
E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)
2 entries
Immediate-early phosphoprotein 57
7 entries
Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)
2 entries
Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)
1 entry
Viral interleukin-8 homolog (vIL8)
2 entries
Protein RL1 (IRL1) (TRL1) (Protein HKLF1)
1 entry
Uncharacterized protein IRL2 (TRL2)
1 entry
Uncharacterized protein IRL3 (TRL3)
1 entry
Uncharacterized protein IRL4 (TRL4)
1 entry
Uncharacterized protein IRL5 (TRL5)
2 entries
Uncharacterized protein IRL6 (TRL6)
1 entry
Uncharacterized protein IRL7 (TRL7)
1 entry
Uncharacterized protein IRL8 (TRL8)
1 entry
Uncharacterized protein IRL9 (TRL9)
2 entries
Protein IRL10 (TRL10)
1 entry
Viral Fc-gamma receptor-like protein IR11 (gp34)
1 entry
Uncharacterized protein IRL12 (TRL12)
1 entry
Uncharacterized protein IRL13 (TRL13)
1 entry
Uncharacterized protein IRL14
2 entries
Protein IRS1
19 entries
Inner tegument protein
1 entry
Uncharacterized protein HKRFX (J1I)
1 entry
Uncharacterized protein J1L
1 entry
Uncharacterized protein J1S
1 entry
Protein K1
1 entry
Protein K12
1 entry
Protein K15
1 entry
Protein K4.2
1 entry
Protein K6
1 entry
Protein K7
1 entry
Protein K8.1
1 entry
E3 SUMO-protein ligase K-bZIP (EC 2.3.2.-) (E3 SUMO-protein transferase K-bZIP)
35 entries
Thymidine kinase (EC 2.7.1.21)
2 entries
Serine/threonine-protein kinase (EC 2.7.11.1)
3 entries
Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)
1 entry
Protein LANA1
3 entries
Uncharacterized LF1 protein
3 entries
Protein LF2
2 entries
Uncharacterized protein LF3
5 entries
Latent membrane protein 1 (LMP-1) (Protein p63)
3 entries
Latent membrane protein 2 (Terminal protein)
1 entry
Latency-related protein 1
1 entry
Latency-related protein 2
23 entries
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
1 entry
Protein M35
7 entries
Membrane protein UL43
21 entries
Major capsid protein (MCP)
1 entry
Oncoprotein MEQ (MEQ)
2 entries
E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)
1 entry
E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)
1 entry
Post-transcriptional regulator MTA (MTA) (EB2 protein homolog)
3 entries
Major tegument protein (MTP) (Protein p140)
18 entries
Nuclear egress protein 1
17 entries
Nuclear egress protein 2
9 entries
Nuclear phosphoprotein UL3
7 entries
Nuclear protein UL4
12 entries
Replication origin-binding protein (OBP) (OriBP)
2 entries
Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)
2 entries
Structural protein 1 (Structural ORF1 protein)
1 entry
Protein ORF10
1 entry
Protein ORF11
3 entries
Membrane protein 2 (Membrane ORF2 protein)
1 entry
Protein ORF23
1 entry
Protein ORF24
1 entry
Protein ORF27
1 entry
Protein ORF28
1 entry
Uncharacterized protein sORF3/4
1 entry
Protein ORF30
2 entries
Phosphoprotein 32 (ORF32 Phosphoprotein)
1 entry
Protein ORF35
1 entry
Complement control protein (KCP)
1 entry
Protein ORF45
1 entry
Tegument protein ORF48
1 entry
Protein ORF49
1 entry
Replication and transcription activator (RTA) (EC 2.3.2.27)
1 entry
Tegument protein ORF52 (Kaposi's sarcoma-associated herpesvirus inhibitor of cGAS) (KicGAS)
2 entries
Uncharacterized protein 57 (Uncharacterized ORF57 protein)
1 entry
Protein ORF58
1 entry
Protein ORF75
2 entries
Protein ORF A
2 entries
Protein ORF B
2 entries
Protein ORF C
2 entries
Protein ORF D
1 entry
Uncharacterized protein ORFE
3 entries
Putative OX-2 membrane glycoprotein homolog (Protein U85)
4 entries
Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural protein)
10 entries
DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)
19 entries
Portal protein
2 entries
Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) (Basic phosphoprotein) (BPP) (Phosphoprotein UL32) (Tegument protein UL32)
1 entry
Phosphoprotein pp24
1 entry
Phosphoprotein pp38
3 entries
65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83)
2 entries
Protein pp71
4 entries
Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
22 entries
DNA primase (EC 2.7.7.-)
24 entries
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)
19 entries
Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)
1 entry
Protein RJ1 (Protein LT1)
1 entry
Membrane glycoprotein RL11
1 entry
Uncharacterized protein RL12
1 entry
Membrane protein RL13
1 entry
Protein RL5A
1 entry
Protein RL8A
1 entry
Protein RL9A
3 entries
Accessory factor US11 (Vmw21)
2 entries
Uncharacterized protein RPMS1
24 entries
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
17 entries
Small capsomere-interacting protein
1 entry
Semaphorin-like protein A3
11 entries
Virion host shutoff protein (Vhs) (EC 3.1.27.-)
2 entries
Saimiri transformation-associated protein (Collagen-like protein) (stpC)
9 entries
Tegument protein UL46 homolog (Tegument protein VP11/12 homolog)
1 entry
Tegument protein UL11
9 entries
Tegument protein UL14 homolog
8 entries
Tegument protein UL21
12 entries
Tegument protein UL47 homolog
8 entries
Tegument protein UL55 homolog
22 entries
Tegument protein UL51 homolog
1 entry
Tegument protein (67 kDa phosphorylated protein)
2 entries
Tegument protein UL21
1 entry
Protein tio
3 entries
Tyrosine-protein kinase-interacting protein (Tip)
1 entry
Protein TRL14
25 entries
Tripartite terminase subunit 1
13 entries
Tripartite terminase subunit 2
20 entries
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
2 entries
Protein HHLF1
20 entries
Triplex capsid protein 1
18 entries
Triplex capsid protein 2
1 entry
Transforming protein STP
6 entries
Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
3 entries
Protein U10
1 entry
Uncharacterized 40.6 kDa protein
2 entries
Uncharacterized protein U13
1 entry
Protein UL131A
1 entry
Uncharacterized protein UL147A
1 entry
Protein UL148A
1 entry
Protein UL148B
1 entry
Protein UL148C
1 entry
Protein UL148D
2 entries
Protein U15
1 entry
Uncharacterized protein UL150A
2 entries
Protein U17/U16
3 entries
Protein U17
3 entries
Putative immediate early glycoprotein (Protein U18)
2 entries
Glycoprotein U20
4 entries
U21 glycoprotein
2 entries
Glycoprotein U22
2 entries
Glycoprotein U23
3 entries
U24 protein
1 entry
Uncharacterized protein U24A
1 entry
Protein U54
2 entries
Uncharacterized protein U6
1 entry
Uncharacterized protein U61
1 entry
Protein U62
1 entry
Protein U7
1 entry
Uncharacterized protein U78
4 entries
Protein U79
1 entry
Protein U8
1 entry
Protein U9
1 entry
Protein U90
2 entries
Protein U91
2 entries
Uncharacterized protein U95
3 entries
Glycoprotein UL1
2 entries
Uncharacterized protein UL2
2 entries
Uncharacterized protein UL3
3 entries
Early glycoprotein GP48
2 entries
Protein UL5
2 entries
Uncharacterized protein UL6
2 entries
CEACAM1-like protein UL7
1 entry
Membrane protein UL8
2 entries
Membrane glycoprotein UL9
2 entries
Uncharacterized protein UL10
1 entry
Uncharacterized protein UL101
1 entry
Uncharacterized protein UL106
1 entry
Uncharacterized protein UL107
1 entry
Uncharacterized protein UL108
1 entry
Uncharacterized protein UL109
1 entry
Uncharacterized protein UL110
2 entries
Uncharacterized protein UL116
2 entries
Protein UL117
2 entries
Viral Fc-gamma receptor-like protein UL119 (gp68)
2 entries
Protein UL11
1 entry
Uncharacterized protein UL12
2 entries
Membrane protein UL120
2 entries
Membrane protein UL121
2 entries
Uncharacterized protein UL124
1 entry
Uncharacterized protein UL125
1 entry
Uncharacterized protein UL126
1 entry
Uncharacterized protein UL127
2 entries
Envelope protein UL128
1 entry
Uncharacterized protein UL129
11 entries
Serine/threonine-protein kinase UL13 (EC 2.7.11.1)
2 entries
Envelope glycoprotein UL130
1 entry
Uncharacterized protein UL131
3 entries
Envelope glycoprotein UL132 (L3)
1 entry
Protein UL133
2 entries
Protein UL135
2 entries
Protein UL136
1 entry
Protein UL138
1 entry
Membrane glycoprotein UL139
2 entries
Uncharacterized protein UL14
1 entry
Protein UL140
1 entry
Protein UL141
1 entry
Membrane glycoprotein UL142
2 entries
Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
1 entry
Protein UL145
2 entries
Putative viral CXC chemokine 2 (vCXCL2)
1 entry
Membrane protein UL148
1 entry
Uncharacterized protein UL150
2 entries
Uncharacterized protein UL15A
1 entry
Large terminase protein homolog UL15b
2 entries
Protein UL16
3 entries
Protein UL17
2 entries
Glycoprotein UL18
2 entries
Uncharacterized protein UL19
10 entries
Protein UL20
1 entry
Uncharacterized protein UL21
2 entries
Uncharacterized protein UL21A
2 entries
Glycoprotein UL22A
2 entries
Tegument protein UL23
21 entries
Protein UL24 homolog
2 entries
Tegument protein UL26
2 entries
Protein UL27
1 entry
Uncharacterized protein UL28
1 entry
Uncharacterized protein UL29
2 entries
Protein UL29/28
2 entries
Uncharacterized protein UL30
2 entries
Protein UL31
15 entries
Packaging protein UL32
6 entries
G-protein coupled receptor homolog U12
3 entries
Transcriptional regulator UL34
2 entries
Protein UL35
1 entry
Uncharacterized protein UL36
4 entries
Apoptosis inhibitor U19
1 entry
Uncharacterized protein UL39
1 entry
Nuclear protein UL4 homolog
2 entries
Protein UL40
1 entry
Uncharacterized protein UL41
2 entries
Protein UL41A
3 entries
Protein UL42
3 entries
Tegument protein UL43
9 entries
Protein U33
2 entries
Packaging protein UL32 homolog
3 entries
Protein UL56
1 entry
Uncharacterized protein UL58
1 entry
Uncharacterized protein UL59
1 entry
Uncharacterized protein UL60
1 entry
Uncharacterized protein UL61
1 entry
Uncharacterized protein UL62
1 entry
Uncharacterized protein UL63
1 entry
Uncharacterized protein UL64
1 entry
Uncharacterized protein UL65
1 entry
Uncharacterized protein UL66
1 entry
Uncharacterized protein UL67
1 entry
Uncharacterized protein UL68
1 entry
Uncharacterized protein UL74A
2 entries
Protein UL76
2 entries
Protein UL78
10 entries
Protein U52
1 entry
Uncharacterized protein UL81
3 entries
Protein UL84
10 entries
Protein U58
6 entries
Protein U59
1 entry
Uncharacterized protein UL90
8 entries
Protein U62
12 entries
Protein U63
13 entries
Protein U67
10 entries
Protein U68
5 entries
Phosphotransferase UL97 homolog (EC 2.7.1.-)
22 entries
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
2 entries
Protein US1
11 entries
Protein US2
14 entries
Serine/threonine-protein kinase US3 homolog (EC 2.7.11.1)
1 entry
Uncharacterized protein US4
2 entries
Uncharacterized protein US5
3 entries
Unique short US6 glycoprotein
2 entries
Membrane glycoprotein US7
2 entries
Membrane glycoprotein US8
2 entries
Membrane glycoprotein US9
13 entries
Virion protein US10
3 entries
Membrane glycoprotein US11
2 entries
Uncharacterized protein HVLF6
2 entries
Membrane protein US13
2 entries
Membrane protein US14
2 entries
Membrane protein US15
2 entries
Protein US16
2 entries
Protein US17
3 entries
Transmembrane protein US18
3 entries
Transmembrane protein HWLF4
3 entries
Transmembrane protein HWLF3
2 entries
Membrane protein US21
2 entries
Early nuclear protein HWLF1 (Tegument protein US22)
2 entries
Protein US23
2 entries
Tegument protein US24
1 entry
Uncharacterized protein US25
2 entries
Protein US26
2 entries
Envelope glycoprotein US27
3 entries
G-protein coupled receptor homolog US28 (HHRF3)
2 entries
Uncharacterized protein HHRF4
2 entries
Uncharacterized protein HHRF5
2 entries
Uncharacterized protein HHRF6
2 entries
Protein US32
1 entry
Uncharacterized protein HHLF3
1 entry
Uncharacterized protein US33A
2 entries
Protein US34
2 entries
Uncharacterized protein US34A
1 entry
Uncharacterized protein HHLF2
1 entry
Uncharacterized protein US36
1 entry
Uncharacterized 14.2 kDa protein
1 entry
Uncharacterized 15.5 kDa protein
1 entry
Uncharacterized 15.7 kDa protein
1 entry
Uncharacterized 16.7 kDa protein
1 entry
Uncharacterized 16.6 kDa protein
3 entries
Protein US8.5
12 entries
Envelope protein US9 homolog (Envelope protein 76) (ORF76 protein)
1 entry
30 kDa major early protein
1 entry
Uncharacterized protein U55A
1 entry
Uncharacterized protein U55B
1 entry
Protein vCCL3
1 entry
CARD domain-containing protein E10
1 entry
viral cyclin homolog (v-cyclin)
1 entry
Viral FLICE protein (vFLIP)
4 entries
Uncharacterized gene 1 protein
2 entries
Uncharacterized gene 2 protein
3 entries
Gene 3 protein
1 entry
Uncharacterized gene 4 protein
1 entry
Uncharacterized gene 5 protein
1 entry
Uncharacterized gene 6a protein
1 entry
Uncharacterized gene 6b protein
1 entry
Uncharacterized gene 7 protein
1 entry
Uncharacterized gene 9 protein
3 entries
Uncharacterized gene 10 protein
4 entries
Uncharacterized gene 11 protein
3 entries
Uncharacterized gene 12 protein
1 entry
Protein E6C
1 entry
Bcl-2-like gene 16 protein
3 entries
Uncharacterized gene 23 protein
3 entries
Uncharacterized gene 27 protein
2 entries
Uncharacterized gene 28 protein
1 entry
Gene 34 protein
2 entries
Probable inactive protein kinase 38
2 entries
Uncharacterized gene 40 protein
2 entries
Uncharacterized gene 41 protein
3 entries
Uncharacterized gene 45 protein
3 entries
Uncharacterized gene 48 protein
2 entries
Uncharacterized gene 49 protein
2 entries
Gene 51 glycoprotein
3 entries
Uncharacterized gene 52 protein
3 entries
Gene 58 protein
5 entries
DNA polymerase processivity factor
2 entries
Uncharacterized gene 67 protein (IR6 protein)
1 entry
Uncharacterized gene 69 protein
2 entries
Uncharacterized gene 71 protein
1 entry
Uncharacterized gene 72 protein
1 entry
Uncharacterized gene 73 protein
2 entries
G-protein coupled receptor 74
3 entries
Uncharacterized gene 75 protein
1 entry
Uncharacterized gene 81 protein
1 entry
Uncharacterized gene 82 protein
1 entry
Uncharacterized gene 83 protein
1 entry
Uncharacterized gene 85 protein
1 entry
Uncharacterized gene 86 protein
1 entry
Uncharacterized gene 87 protein
1 entry
Uncharacterized gene 90 protein
1 entry
Uncharacterized gene 93 protein
1 entry
Uncharacterized gene 97 protein
1 entry
Uncharacterized gene A1 protein
1 entry
Uncharacterized gene A10 protein
1 entry
Uncharacterized protein A2
1 entry
Uncharacterized gene A4 protein
1 entry
G-protein coupled receptor A5
1 entry
Uncharacterized gene A6 protein
1 entry
Putative C-type lectin protein A7
1 entry
Uncharacterized gene A8 protein
1 entry
Putative apoptosis regulator A9
2 entries
G-protein coupled receptor
1 entry
G-protein coupled receptor E1
1 entry
Uncharacterized gene E2 protein
1 entry
SUSHI domain-containing protein E3
1 entry
Uncharacterized gene E4 protein
1 entry
G-protein coupled receptor E6
1 entry
Uncharacterized gene E9 protein
2 entries
UL37 immediate early glycoprotein
1 entry
Envelope glycoprotein J
1 entry
Glycoprotein GX
1 entry
Envelope glycoprotein GP340 (Membrane antigen) (MA)
1 entry
viral G-protein coupled receptor (vGPCR) (Protein ORF74)
1 entry
Viral inhibitor of caspase-8-induced apoptosis (vICA)
5 entries
Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
4 entries
Viral transcription factor IE2 (IE2) (Protein UL122)
2 entries
30 kDa immediate-early protein 2 (IE2)
1 entry
Immediate-early protein IE-G
1 entry
Viral interleukin-6 homolog (vIL-6)
1 entry
VIRF-1
1 entry
Viral IRF2-like protein (vIRF-2)
1 entry
Viral IRF3-like protein (VIRF-3)
1 entry
Viral IRF4-like protein (vIRF-4)
1 entry
Virulence factor MDV010 (Viral lipase homolog) (vLIP)
1 entry
Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) (vMIP-1B)
1 entry
Probable nuclear antigen
3 entries
Probable membrane antigen 3 (Tegument protein)
10 entries
Tegument protein VP16 (Alpha trans-inducing protein) (Alpha-TIF) (ICP25) (Vmw65)
11 entries
Tegument protein VP22
2 entries
38 kDa phosphoprotein (Phosphoprotein pp38)
2 entries
Probable membrane antigen 75 (Tegument protein)
5 entries
DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)
1 entry
Viral protein kinase (EC 2.7.11.1)
1 entry
Protein U1
1 entry
U10 protein
1 entry
Protein U2
4 entries
Protein U25
5 entries
Protein U26
3 entries
Protein U3
4 entries
Protein U4
1 entry
Protein U5
3 entries
G-protein coupled receptor homolog U51
3 entries
Protein U54
2 entries
Uncharacterized protein U55
1 entry
Protein U7
2 entries
Protein U8
3 entries
Protein U84
2 entries
Protein U9
3 entries
Protein U94
1 entry
Viral Lymphotactin (Viral XCL1) (vSCL1)
1 entry
Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)
1 entry
Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)
1 entry
Uncharacterized protein EC-RF4
1 entry
Uncharacterized protein HHLF4
1 entry
Uncharacterized protein HHRF1
1 entry
Uncharacterized 16.1 kDa protein (ORF1)
Alcelaphine gammaherpesvirus 1 taxid:35252
| Protein | ModelArchive |
| A2 | ma-jd-viral-12263 |
| AHV-sema | ma-jd-viral-54620 |
Alcelaphine gammaherpesvirus 2 taxid:138184
Alcelaphine herpesvirus 1 (strain C500) taxid:654901
Aotine betaherpesvirus 1 taxid:50290
Bovine gammaherpesvirus 6 taxid:1504288
Bovine herpesvirus 1 taxid:10320
Bovine herpesvirus 1.1 (strain Cooper) taxid:10323
Bovine herpesvirus 1.1 (strain Jura) taxid:31518
| Protein | ModelArchive |
| E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase... | ma-jd-viral-58609 |
Bovine herpesvirus 1.1 (strain P8-2) taxid:10324
| Protein | ModelArchive |
| Envelope glycoprotein D (gD) (Glycoprotein IV) | ma-jd-viral-07522 |
Bovine herpesvirus type 1.1 taxid:79889
Canid alphaherpesvirus 1 taxid:170325
Caviid betaherpesvirus 2 taxid:33706
Cercopithecine alphaherpesvirus 2 taxid:10317
Cercopithecine alphaherpesvirus 9 taxid:35246
Cercopithecine herpesvirus 1 taxid:10325
Cercopithecine herpesvirus 1 (strain E2490) taxid:260965
| Protein | ModelArchive |
| ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein)... | ma-jd-viral-62159 |
Cercopithecine herpesvirus 16 taxid:340907
Cercopithecine herpesvirus 9 (strain DHV) taxid:36348
Chimpanzee herpesvirus strain 105640 taxid:332937
Cricetid gammaherpesvirus 2 taxid:1605972
Cynomolgus cytomegalovirus taxid:1919083
Elephant endotheliotropic herpesvirus 4 taxid:548914
Elephant endotheliotropic herpesvirus 5 taxid:768738
Elephantid herpesvirus 1 taxid:146015
Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) taxid:654902
| Protein | ModelArchive |
| Protein ORF A | ma-jd-viral-36498 |
| Protein ORF B | ma-jd-viral-13328 |
| Protein U4 | ma-jd-viral-13325 |
| Protein U68 | ma-jd-viral-52996 |
| Tegument protein UL51 homolog | ma-jd-viral-35765 |
Epstein-Barr virus (strain AG876) taxid:82830
Epstein-Barr virus (strain B95-8) taxid:10377
Epstein-Barr virus (strain GD1) taxid:10376
Equid alphaherpesvirus 1 taxid:10326
Equid alphaherpesvirus 3 taxid:80341
Equid alphaherpesvirus 4 taxid:10331
Equid alphaherpesvirus 8 taxid:39637
Equid alphaherpesvirus 9 taxid:55744
Equid gammaherpesvirus 2 taxid:12657
Equid gammaherpesvirus 5 taxid:10371
Equine herpesvirus 1 (strain AB1) taxid:10328
| Protein | ModelArchive |
| Envelope glycoprotein E (gE) | ma-jd-viral-00326 |
| Envelope glycoprotein I | ma-jd-viral-06387 |
| Packaging protein UL32 homolog (Glycoprotein 300) (GP300) | ma-jd-viral-40921 |
Equine herpesvirus 1 (strain Ab4p) taxid:31520
Equine herpesvirus 1 (strain HH1) taxid:310537
| Protein | ModelArchive |
| Uncharacterized gene 1 protein | ma-jd-viral-40542 |
Equine herpesvirus 1 (strain HVS25A) taxid:10327
| Protein | ModelArchive |
| Envelope glycoprotein H (gH) | ma-jd-viral-16908 |
| Thymidine kinase (EC 2.7.1.21) | ma-jd-viral-05904 |
Equine herpesvirus 1 (strain Kentucky A) taxid:10329
Equine herpesvirus 1 (strain Kentucky D) taxid:10330
| Protein | ModelArchive |
| Envelope glycoprotein B (gB) | ma-jd-viral-31223 |
| Envelope glycoprotein C (gC) (Glycoprotein 13) | ma-jd-viral-01823 |
| Envelope protein UL45 homolog | ma-jd-viral-16456 |
Equine herpesvirus 1 (strain V592) taxid:310273
Equine herpesvirus 2 (strain 86/87) taxid:82831
Equine herpesvirus 2 (strain T400/3) taxid:82832
| Protein | ModelArchive |
| Viral interleukin-10 homolog (vIL-10) | ma-jd-viral-13428 |
Equine herpesvirus 4 (strain 1942) taxid:10333
Falconid herpesvirus 1 taxid:1510155
Gallid alphaherpesvirus 2 taxid:10390
Gallid alphaherpesvirus 3 taxid:35250
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) taxid:10389
Gallid herpesvirus 2 (strain GA) taxid:10388
| Protein | ModelArchive |
| Envelope glycoprotein L (gL) | ma-jd-viral-09079 |
| Virion protein US10 homolog | ma-jd-viral-16121 |
Gallid herpesvirus 2 (strain RB-1b) taxid:33707
| Protein | ModelArchive |
| Envelope glycoprotein B (gB) | ma-jd-viral-31201 |
Guinea pig cytomegalovirus (strain 22122) taxid:103920
| Protein | ModelArchive |
| Envelope glycoprotein B (gB) | ma-jd-viral-31188 |
| Envelope glycoprotein H (gH) | ma-jd-viral-16930 |
| Envelope glycoprotein L (gL) | ma-jd-viral-00343 |
| Protein GP96 | ma-jd-viral-18507 |
Hawaiian green turtle herpesvirus taxid:70564
Human betaherpesvirus 6A taxid:32603
Human betaherpesvirus 7 taxid:10372
Human cytomegalovirus taxid:10359
Human cytomegalovirus (strain 5508) taxid:69168
| Protein | ModelArchive |
| Envelope glycoprotein L (gL) | ma-jd-viral-00341 |
Human cytomegalovirus (strain AD169) taxid:10360
Human cytomegalovirus (strain Merlin) taxid:295027
Human cytomegalovirus (strain Toledo) taxid:311339
Human cytomegalovirus (strain Towne) taxid:10363
Human herpesvirus 1 taxid:10298
Human herpesvirus 1 (strain 17) taxid:10299
Human herpesvirus 1 (strain MP) taxid:10307
| Protein | ModelArchive |
| Envelope glycoprotein K (Syncytial protein) | ma-jd-viral-49381 |
Human herpesvirus 1 (strain R15) taxid:36345
| Protein | ModelArchive |
| Envelope glycoprotein K (Syncytial protein) | ma-jd-viral-49381 |
Human herpesvirus 2 taxid:10310
Human herpesvirus 2 (strain 333) taxid:10313
Human herpesvirus 2 (strain G) taxid:10314
| Protein | ModelArchive |
| Virion host shutoff protein (Vhs) (EC 3.1.27.-) | ma-jd-viral-22425 |
Human herpesvirus 2 (strain HG52) taxid:10315
Human herpesvirus 3 taxid:10335
Human herpesvirus 4 type 2 taxid:12509
| Protein | ModelArchive |
| Latent membrane protein 1 (Protein p63) | ma-jd-viral-30641 |
Human herpesvirus 6A (strain GS) taxid:10369
| Protein | ModelArchive |
| Envelope glycoprotein H (gH) | ma-jd-viral-16932 |
Human herpesvirus 6A (strain Uganda-1102) taxid:10370
Human herpesvirus 6B taxid:32604
Human herpesvirus 6B (strain Z29) taxid:36351
Human herpesvirus 7 (strain JI) taxid:57278
Human herpesvirus 7 (strain MUK) taxid:57279
| Protein | ModelArchive |
| Triplex capsid protein 2 | ma-jd-viral-04783 |
Human herpesvirus 7 (strain RK) taxid:262398
| Protein | ModelArchive |
| U21 glycoprotein (gp60) | ma-jd-viral-36538 |
Human herpesvirus 8 taxid:37296
Human herpesvirus 8 type P (isolate GK18) taxid:868565
Infectious laryngotracheitis virus taxid:10386
Infectious laryngotracheitis virus (strain Thorne V882) taxid:10344
Leporid alphaherpesvirus 4 taxid:481315
Macropodid alphaherpesvirus 1 taxid:137443
Meleagrid herpesvirus 1 taxid:37108
Murid herpesvirus 1 taxid:10366
Murid herpesvirus 1 (strain Smith) taxid:10367
Murine roseolovirus taxid:1940555
Ovine gammaherpesvirus 2 taxid:10398
Panine betaherpesvirus 2 taxid:188763
Papio ursinus cytomegalovirus taxid:1667587
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) taxid:670426
Pteropodid alphaherpesvirus 1 taxid:1343901
Rat cytomegalovirus (isolate England) taxid:1261657
Rhesus cytomegalovirus (strain 68-1) taxid:47929
Saimiriine betaherpesvirus 4 taxid:1535247
Simian cytomegalovirus (strain Colburn) taxid:50292
Suid herpesvirus 1 taxid:10345
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) taxid:31523
| Protein | ModelArchive |
| Envelope glycoprotein B (gB) | ma-jd-viral-31207 |
| Tripartite terminase subunit 1 | ma-jd-viral-61489 |
Suid herpesvirus 1 (strain Kaplan) taxid:33703
Suid herpesvirus 1 (strain NIA-3) taxid:10349
| Protein | ModelArchive |
| Protein US2 homolog (28 kDa protein) | ma-jd-viral-21068 |
| Serine/threonine-protein kinase UL13 (EC 2.7.11.1) | ma-jd-viral-24774 |
| Tegument protein UL14 | ma-jd-viral-14631 |
Suid herpesvirus 1 (strain Rice) taxid:10350
| Protein | ModelArchive |
| Envelope glycoprotein G (gG) | ma-jd-viral-64437 |