Cytomegalovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

370 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 404 entries)

190 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
CEP2_HCMVA Cytoplasmic envelopment protein 2
US34_HCMVA Protein US34
US34A_HCMVA Uncharacterized protein US34A
UL07_HCMVA CEACAM1-like protein UL7
UL11P_HCMVA Protein UL11
US15_HCMVA Uncharacterized protein HVLF3
US18_HCMVA Transmembrane protein US18
UL97_HCMVA Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)
UL109_HCMVA Uncharacterized protein UL109
UL60_HCMVA Uncharacterized protein UL60
UL62_HCMVA Uncharacterized protein UL62
UL66_HCMVA Uncharacterized protein UL66
UL107_HCMVA Uncharacterized protein UL107
UL13_HCMVA Uncharacterized protein UL13
UL15A_HCMVA Uncharacterized protein UL15A
UL17_HCMVA Uncharacterized protein UL17
UL58_HCMVA Uncharacterized protein UL58
UL84_HCMVA Protein UL84
US31_HCMVA Uncharacterized protein HHRF6
IR14_HCMVA Uncharacterized protein IRL14
IR05_HCMVA Uncharacterized protein IRL5 (TRL5)
PP65_HCMVA 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
UL38_HCMVA Apoptosis inhibitor UL38
UL35_HCMVA Protein UL35
UL52_HCMVA Packaging protein UL32 homolog (Protein HFRF1)
US10_HCMVA Unique short US10 glycoprotein (Protein HXLF2) (gpUS10)
UL120_HCMVA Uncharacterized protein UL120
UL131_HCMVA Uncharacterized protein UL131
UL128_HCMVA Uncharacterized protein UL128
UL34_HCMVA Transcriptional regulator UL34
UL40_HCMVA Protein UL40
UL87_HCMVA Protein UL87
VIE1_HCMVA 55 kDa immediate-early protein 1 (IE1)
CVC2_HCMVA Capsid vertex component 2
CEP1_HCMVA Cytoplasmic envelopment protein 1
ITP_HCMVA Inner tegument protein
J1I_HCMVA Uncharacterized protein HKRFX (J1I)
EP84_HCMVA Early phosphoprotein p84 [Cleaved into: p20; p26; p28]
GB_HCMVA Envelope glycoprotein B (gB)
GH_HCMVA Envelope glycoprotein H (gH)
CVC1_HCMVA Capsid vertex component 1
ICP27_HCMVA mRNA export factor ICP27 homolog
J1L_HCMVA Uncharacterized protein J1L
HEPA_HCMVA DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
IR08_HCMVA Uncharacterized protein IRL8 (TRL8)
LTP_HCMVA Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
GL_HCMVA Envelope glycoprotein L (gL)
IL10H_HCMVA Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
IR01_HCMVA Uncharacterized protein HKLF1 (IRL1) (TRL1)
CEP3_HCMVA Cytoplasmic envelopment protein 3
DUT_HCMVA Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
MCP_HCMVA Major capsid protein (MCP)
GO_HCMVA Glycoprotein O (gO)
DNBI_HCMVA Major DNA-binding protein
GM_HCMVA Envelope glycoprotein M (gM)
IR06_HCMVA Uncharacterized protein IRL6 (TRL6)
HELI_HCMVA DNA replication helicase (EC 3.6.4.-)
J1S_HCMVA Uncharacterized protein J1S
PP71_HCMVA Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument ...
PRIM_HCMVA DNA primase (EC 2.7.7.-)
RIR1_HCMVA Ribonucleoside-diphosphate reductase large subunit-like protein
IRS1_HCMVA Protein IRS1 (HQRF1)
NEC1_HCMVA Nuclear egress protein 1
TRM2_HCMVA Tripartite terminase subunit 2
IR10_HCMVA Protein IRL10 (TRL10)
IR02_HCMVA Uncharacterized protein IRL2 (TRL2)
IR03_HCMVA Uncharacterized protein IRL3 (TRL3)
IR12_HCMVA Uncharacterized protein IRL12 (TRL12)
SCAF_HCMVA Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
IR13_HCMVA Uncharacterized protein IRL13 (TRL13)
UL27_HCMVA Protein UL27
UL29_HCMVA Uncharacterized protein UL29
UL91_HCMVA Protein UL91
US35_HCMVA Uncharacterized protein HHLF2
US03_HCMVA Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)
UL33_HCMVA G-protein coupled receptor homolog UL33 (vGPCR UL33)
UL21_HCMVA Uncharacterized protein UL21
VIE2_HCMVA Viral transcription factor IE2 (IE2) (Protein UL122)
US33_HCMVA Uncharacterized protein HHLF3
US01_HCMVA Uncharacterized protein HQLF3
UL14_HCMVA Uncharacterized protein UL14
UL96_HCMVA Protein UL96
UL10_HCMVA Uncharacterized protein UL10
UL36_HCMVA Uncharacterized protein UL36
UL41A_HCMVA Protein UL41A
UL67_HCMVA Uncharacterized protein UL67
TR14_HCMVA Protein TRL14
US36_HCMVA Uncharacterized protein US36
PORTL_HCMVA Portal protein
NEC2_HCMVA Nuclear egress protein 2
TRX1_HCMVA Triplex capsid protein 1
IR04_HCMVA Uncharacterized protein IRL4 (TRL4)
US04_HCMVA Uncharacterized protein US4
SCP_HCMVA Small capsomere-interacting protein
IR11_HCMVA Viral Fc-gamma receptor-like protein IR11 (gp34)
TRM1_HCMVA Tripartite terminase subunit 1
TRS1_HCMVA Protein HHLF1
TRX2_HCMVA Triplex capsid protein 2
IR07_HCMVA Uncharacterized protein IRL7 (TRL7)
US26_HCMVA Uncharacterized protein HHLF5
UL03_HCMVA Uncharacterized protein UL3
UL28_HCMVA Uncharacterized protein UL28
UL19_HCMVA Uncharacterized protein UL19
UL43_HCMVA Tegument protein UL43
UL21A_HCMVA Uncharacterized protein UL21A
UL65_HCMVA Uncharacterized protein UL65
PP85_HCMVA Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
US29_HCMVA Uncharacterized protein HHRF4
US32_HCMVA Uncharacterized protein HHRF7
UL124_HCMVA Uncharacterized protein UL124
UL18_HCMVA Glycoprotein UL18
UL16P_HCMVA Protein UL16
UL95_HCMVA Protein UL95
US23_HCMVA Tegument protein US23 (Protein HHLF7)
UL110_HCMVA Uncharacterized protein UL110
UL88_HCMVA Protein UL88
US08_HCMVA Unique short US8 glycoprotein (Protein HXLF4) (gpUS8)
UL81_HCMVA Uncharacterized protein UL81
UL117_HCMVA Protein UL117
TRM3_HCMVA Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
US09_HCMVA Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)
US07_HCMVA Unique short US7 glycoprotein (Protein HXLF5) (gpUS7)
US11_HCMVA Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)
IR09_HCMVA Uncharacterized protein IRL9 (TRL9)
US19_HCMVA Transmembrane protein HWLF4
US05_HCMVA Uncharacterized protein US5
US20_HCMVA Transmembrane protein HWLF3
UL04_HCMVA Early glycoprotein GP48
UL108_HCMVA Uncharacterized protein UL108
UL42_HCMVA Uncharacterized protein UL42
US30_HCMVA Uncharacterized protein HHRF5
US02_HCMVA Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US21_HCMVA Uncharacterized protein HWLF2
UL05_HCMVA Protein UL5
PP150_HCMVA Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) ...
UL41_HCMVA Uncharacterized protein UL41
UL106_HCMVA Uncharacterized protein UL106
UL121_HCMVA Membrane protein UL121
UL20_HCMVA Uncharacterized protein UL20
UL76_HCMVA Protein UL76
UL92_HCMVA Protein UL92
TEG7_HCMVA Tegument protein UL51 homolog
UL08_HCMVA Membrane protein UL8
UL90_HCMVA Uncharacterized protein UL90
US28_HCMVA G-protein coupled receptor homolog US28 (HHRF3)
US13_HCMVA Uncharacterized protein HVLF5
UL23_HCMVA Tegument protein UL23
UL26_HCMVA Tegument protein UL26
VP22_HCMVA Protein UL24
US06_HCMVA Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)
UL49_HCMVA Uncharacterized protein UL49 (Protein HFLF5)
UL63_HCMVA Uncharacterized protein UL63
US12_HCMVA Uncharacterized protein HVLF6
UL31_HCMVA Protein UL31
UL101_HCMVA Uncharacterized protein UL101
US25_HCMVA Uncharacterized protein US25
UL130_HCMVA Uncharacterized protein UL130
UL22A_HCMVA Glycoprotein UL22A
UL129_HCMVA Uncharacterized protein UL129
US22_HCMVA Early nuclear protein HWLF1 (Tegument protein US22)
UL02_HCMVA Uncharacterized protein UL2
VGLI_HCMVA UL37 immediate early glycoprotein
UL12_HCMVA Uncharacterized protein UL12
UL64_HCMVA Uncharacterized protein UL64
UL116_HCMVA Uncharacterized protein UL116
UL125_HCMVA Uncharacterized protein UL125
UL30_HCMVA Uncharacterized protein UL30
UL59_HCMVA Uncharacterized protein UL59
UL61_HCMVA Uncharacterized protein UL61
US24_HCMVA Tegument protein US24 (Protein HHLF6)
UL119_HCMVA Viral Fc-gamma receptor-like protein UL119 (gp68)
UL39_HCMVA Uncharacterized protein UL39
UL78_HCMVA Uncharacterized protein UL78
UL01_HCMVA Glycoprotein UL1
UL79_HCMVA Protein UL79
UL68_HCMVA Uncharacterized protein UL68
UL06_HCMVA Uncharacterized protein UL6
US27_HCMVA G-protein coupled receptor homolog US27 (HHRF2)
VPAP_HCMVA DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
US14_HCMVA Uncharacterized protein HVLF4
US16_HCMVA Uncharacterized protein HVLF2
UL09_HCMVA Uncharacterized protein UL9
UL132_HCMVA Envelope glycoprotein UL132 (L3)
UNG_HCMVA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL127_HCMVA Uncharacterized protein UL127
US17_HCMVA Uncharacterized protein HVLF1
UL126_HCMVA Uncharacterized protein UL126
GN_HCMVA Envelope glycoprotein N
DPOL_HCMVA DNA polymerase catalytic subunit (EC 2.7.7.7)
AN_HCMVA Alkaline nuclease (EC 3.1.-.-)

166 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
CEP1_HCMVM Cytoplasmic envelopment protein 1
GB_HCMVM Envelope glycoprotein B (gB)
US20_HCMVM Membrane protein US20
US33A_HCMVM Uncharacterized protein US33A
US31_HCMVM Uncharacterized protein US31
UL117_HCMVM Protein UL117 (pUL117)
UL74A_HCMVM Uncharacterized protein UL74A
VICA_HCMVM Viral inhibitor of caspase-8-induced apoptosis (vICA)
UL124_HCMVM Uncharacterized protein UL124
UL132_HCMVM Envelope glycoprotein UL132
UL139_HCMVM Membrane glycoprotein UL139
UL19_HCMVM Uncharacterized protein UL19
UL26_HCMVM Tegument protein UL26
UL41A_HCMVM Protein UL41A
IR06_HCMVM Uncharacterized protein IRL6 (TRL6)
IL10H_HCMVM Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
GL_HCMVM Envelope glycoprotein L (gL)
LTP_HCMVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
TRM1_HCMVM Tripartite terminase subunit 1
SCAF_HCMVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
UL09_HCMVM Membrane glycoprotein UL9
UL40_HCMVM Protein UL40
U147A_HCMVM Uncharacterized protein UL147A
US17_HCMVM Protein US17
UL22A_HCMVM Glycoprotein UL22A
UL30_HCMVM Uncharacterized protein UL30
UL78_HCMVM Protein UL78
US21_HCMVM Membrane protein US21
US22_HCMVM Tegument protein US22
UL01_HCMVM Glycoprotein UL1
UL79_HCMVM Protein UL79
DUT_HCMVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CVC1_HCMVM Capsid vertex component 1
CVC2_HCMVM Capsid vertex component 2
IRS1_HCMVM Protein IRS1
ICP27_HCMVM mRNA export factor ICP27 homolog
GM_HCMVM Envelope glycoprotein M (gM)
DNBI_HCMVM Major DNA-binding protein
HEPA_HCMVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
AN_HCMVM Alkaline nuclease (EC 3.1.-.-)
CXCL1_HCMVM Chemokine vCXCL1
IR10_HCMVM Protein IRL10 (TRL10)
PP71_HCMVM Protein pp71
DPOL_HCMVM DNA polymerase catalytic subunit (EC 2.7.7.7)
CEP2_HCMVM Cytoplasmic envelopment protein 2
GH_HCMVM Envelope glycoprotein H (gH)
GO_HCMVM Envelope glycoprotein O
GN_HCMVM Envelope glycoprotein N
HELI_HCMVM DNA replication helicase (EC 3.6.4.-)
MCP_HCMVM Major capsid protein (MCP)
PP85_HCMVM Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
PP150_HCMVM Tegument protein pp150
PRIM_HCMVM DNA primase (EC 2.7.7.-)
ITP_HCMVM Inner tegument protein
NEC2_HCMVM Nuclear egress protein 2
RIR1_HCMVM Ribonucleoside-diphosphate reductase large subunit-like protein
TRM3_HCMVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
PORTL_HCMVM Portal protein
TRM2_HCMVM Tripartite terminase subunit 2
RL8A_HCMVM Protein RL8A
UL17_HCMVM Protein UL17
UL52_HCMVM Packaging protein UL32 homolog
UL18_HCMVM Membrane glycoprotein UL18
UL21A_HCMVM Uncharacterized protein UL21A
US12_HCMVM Uncharacterized protein US12
US06_HCMVM Unique short US6 glycoprotein
UL05_HCMVM Protein UL5
TEG7_HCMVM Tegument protein UL51 homolog
UL116_HCMVM Uncharacterized protein UL116
UL298_HCMVM Protein UL29/28
UL84_HCMVM Protein UL84
US28_HCMVM Envelope protein US28
UL138_HCMVM Protein UL138
UL31_HCMVM Protein UL31
UL33_HCMVM G-protein coupled receptor homolog UL33
UL35_HCMVM Tegument protein UL35
U148B_HCMVM Protein UL148B
UL88_HCMVM Protein UL88
UL87_HCMVM Uncharacterized protein UL87
RL12_HCMVM Uncharacterized protein RL12
US34_HCMVM Protein US34
RL13_HCMVM Membrane protein RL13
US34A_HCMVM Uncharacterized protein US34A
US26_HCMVM Protein US26
TRX1_HCMVM Triplex capsid protein 1
RL5A_HCMVM Protein RL5A
TRS1_HCMVM Protein TRS1
NEC1_HCMVM Nuclear egress protein 1
IR01_HCMVM Uncharacterized protein HKLF1 (IRL1) (TRL1)
PP65_HCMVM 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
RL11_HCMVM Membrane glycoprotein RL11
UL20_HCMVM Membrane protein UL20
UL43_HCMVM Tegument protein UL43
US11_HCMVM Membrane glycoprotein US11
UL121_HCMVM Membrane protein UL121
U131A_HCMVM Protein UL131A
UL49_HCMVM Protein UL49
U148C_HCMVM Protein UL148C
US13_HCMVM Membrane protein US13
UL06_HCMVM Uncharacterized protein UL6
UL11P_HCMVM Protein UL11
SCP_HCMVM Small capsomere-interacting protein
UL14_HCMVM Uncharacterized protein UL14
UL147_HCMVM Putative viral CXC chemokine 2 (vCXCL2)
US08_HCMVM Membrane glycoprotein US8
RL9A_HCMVM Protein RL9A
UL133_HCMVM Protein UL133
UL141_HCMVM Protein UL141
UL142_HCMVM Membrane glycoprotein UL142
UL27_HCMVM Protein UL27
UL92_HCMVM Uncharacterized protein UL92
VP22_HCMVM Tegument protein UL24
TRX2_HCMVM Triplex capsid protein 2
UL23_HCMVM Tegument protein UL23
US32_HCMVM Protein US32
U150A_HCMVM Uncharacterized protein UL150A
U148D_HCMVM Protein UL148D
US15_HCMVM Membrane protein US15
US03_HCMVM Membrane glycoprotein US3
US09_HCMVM Membrane glycoprotein US9
US07_HCMVM Membrane glycoprotein US7
VGLI_HCMVM UL37 immediate early glycoprotein
US14_HCMVM Membrane protein US14
UL42_HCMVM Protein UL42
US24_HCMVM Tegument protein US24
UL130_HCMVM Envelope glycoprotein UL130
UL15A_HCMVM Uncharacterized protein UL15A
VIE1_HCMVM 55 kDa immediate-early protein 1
US16_HCMVM Protein US16
UL135_HCMVM Protein UL135
US27_HCMVM Envelope glycoprotein US27
US29_HCMVM Uncharacterized protein US29
UL04_HCMVM Envelope glycoprotein UL4
UNG_HCMVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
UL95_HCMVM Protein UL95
UL136_HCMVM Protein UL136
UL145_HCMVM Protein UL145
UL38_HCMVM Apoptosis inhibitor UL38
UL10_HCMVM Uncharacterized protein UL10
UL150_HCMVM Uncharacterized protein UL150
U148A_HCMVM Protein UL148A
US01_HCMVM Protein US1
US19_HCMVM Transmembrane protein US19
US23_HCMVM Protein US23
UL140_HCMVM Protein UL140
UL148_HCMVM Membrane protein UL148
UL34_HCMVM Transcriptional regulator UL34
UL76_HCMVM Protein UL76
VIE2_HCMVM Viral transcription factor IE2 (IE2) (Protein UL122)
US30_HCMVM Uncharacterized protein US30
US18_HCMVM Transmembrane protein US18
UL02_HCMVM Uncharacterized protein UL2
UL13_HCMVM Uncharacterized protein UL13
UL144_HCMVM Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
UL97_HCMVM Serine/threonine protein kinase UL97 (EC 2.7.1.-)
VPAP_HCMVM DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
US02_HCMVM Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
UL96_HCMVM Protein UL96
UL16P_HCMVM Protein UL16
UL91_HCMVM Protein UL91
UL07_HCMVM CEACAM1-like protein UL7
UL119_HCMVM Viral Fc-gamma receptor-like protein UL119 (gp68)
UL120_HCMVM Membrane protein UL120
US10_HCMVM Membrane glycoprotein US10
EP84_HCMVM Early phosphoprotein p84
CEP3_HCMVM Cytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

UL298_HCMVA Protein UL29/UL28

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

UL128_HCMVM Envelope protein UL128

11 entries

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
LTP_HCMVT Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
PRIM_HCMVT DNA primase (EC 2.7.7.-)
UL95_HCMVT Protein UL95
UL132_HCMVT Envelope glycoprotein UL132 (L3)
UL147_HCMVT Putative viral CXC chemokine 2 (vCXCL2)
VIE2_HCMVT Viral transcription factor IE2 (IE2) (Protein UL122)
US03_HCMVT Membrane glycoprotein US3
UL17_HCMVT Protein UL17
UL34_HCMVT Transcriptional regulator UL34
UL135_HCMVT Protein UL135
UL136_HCMVT Protein UL136

1 entry

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

UL144_HCMVO Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)