Cytomegalovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Many HCMV proteins are dedicated to interfere with the host adaptive immune system. HCMV US11 reverse the translocation of human class I heavy chains from the host endoplasmic reticulum (ER) back to the cytosol which ultimately results in their degradation by the proteasome. US2 destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. US3 prevents forward transport and maturation of all major histocompatibility complex (MHC) class I molecules by trapping them in the ER. HCMV US6 inhibits expression of MHC class I on the cell surface through TAP (specific transporters associated with antigen presentation) by blocking translocation of peptides from the proteasome into the ER for loading onto MHC class I.

Apoptosis modulation

Viral inhibitor of caspase-8-induced apoptosis (from gene UL36) plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation . Another viral protein vMIA inhibits BAX- but not BAK- mediated apoptosis.

Autophagy modulation

The human cytomegalovirus protein TRS1 inhibits host autophagy process via its interaction with Beclin 1 .

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. HCMV encodes an UL24 homolog that should fullfill this role .

Innate immune response inhibition

HCMV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the viral pp65 protein .
NK cells are a component of the innate immune system which play an important role in the early control of viral infections and also help to drive subsequent adaptive immunity. Several HCMV proteins are involved in the inhibition of NK-cells cytotoxicity including UL16 or UL142 that retain NKGCD2 ligands inside the cell to prevent their cell surface expression .

Host splicing inhibition

HCMV UL69 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

370 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 404 entries)

190 entries

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
TRX1_HCMVA Triplex capsid protein 1
TRX2_HCMVA Triplex capsid protein 2
UL04_HCMVA Early glycoprotein GP48
UL109_HCMVA Uncharacterized protein UL109
UL10_HCMVA Uncharacterized protein UL10
UL117_HCMVA Protein UL117
UL124_HCMVA Uncharacterized protein UL124
UL14_HCMVA Uncharacterized protein UL14
UL19_HCMVA Uncharacterized protein UL19
UL38_HCMVA Apoptosis inhibitor UL38
UL39_HCMVA Uncharacterized protein UL39
UL40_HCMVA Protein UL40
UL78_HCMVA Uncharacterized protein UL78
UL92_HCMVA Protein UL92
LTP_HCMVA Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
IL10H_HCMVA Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
ITP_HCMVA Inner tegument protein
J1I_HCMVA Uncharacterized protein HKRFX (J1I)
J1L_HCMVA Uncharacterized protein J1L
J1S_HCMVA Uncharacterized protein J1S
MCP_HCMVA Major capsid protein (MCP)
NEC1_HCMVA Nuclear egress protein 1
DNBI_HCMVA Major DNA-binding protein
PP71_HCMVA Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument ...
PP65_HCMVA 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
PRIM_HCMVA DNA primase (EC 2.7.7.-)
TR14_HCMVA Protein TRL14
SCP_HCMVA Small capsomere-interacting protein
SCAF_HCMVA Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
TRS1_HCMVA Protein HHLF1
TRM2_HCMVA Tripartite terminase subunit 2
US02_HCMVA Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US27_HCMVA G-protein coupled receptor homolog US27 (HHRF2)
US12_HCMVA Uncharacterized protein HVLF6
US32_HCMVA Uncharacterized protein HHRF7
US17_HCMVA Uncharacterized protein HVLF1
US34_HCMVA Protein US34
US20_HCMVA Transmembrane protein HWLF3
US25_HCMVA Uncharacterized protein US25
US06_HCMVA Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)
UL97_HCMVA Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)
US07_HCMVA Unique short US7 glycoprotein (Protein HXLF5) (gpUS7)
US15_HCMVA Uncharacterized protein HVLF3
US23_HCMVA Tegument protein US23 (Protein HHLF7)
TRM1_HCMVA Tripartite terminase subunit 1
US31_HCMVA Uncharacterized protein HHRF6
US19_HCMVA Transmembrane protein HWLF4
US04_HCMVA Uncharacterized protein US4
US05_HCMVA Uncharacterized protein US5
UNG_HCMVA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US08_HCMVA Unique short US8 glycoprotein (Protein HXLF4) (gpUS8)
US29_HCMVA Uncharacterized protein HHRF4
US30_HCMVA Uncharacterized protein HHRF5
US11_HCMVA Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)
US14_HCMVA Uncharacterized protein HVLF4
US34A_HCMVA Uncharacterized protein US34A
VIE2_HCMVA Viral transcription factor IE2 (IE2) (Protein UL122)
VGLI_HCMVA UL37 immediate early glycoprotein
US13_HCMVA Uncharacterized protein HVLF5
US16_HCMVA Uncharacterized protein HVLF2
US35_HCMVA Uncharacterized protein HHLF2
US36_HCMVA Uncharacterized protein US36
US03_HCMVA Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)
US21_HCMVA Uncharacterized protein HWLF2
US26_HCMVA Uncharacterized protein HHLF5
US09_HCMVA Unique short US9 glycoprotein (Protein HXLF3) (gpUS9)
US01_HCMVA Uncharacterized protein HQLF3
US10_HCMVA Unique short US10 glycoprotein (Protein HXLF2) (gpUS10)
US28_HCMVA G-protein coupled receptor homolog US28 (HHRF3)
US22_HCMVA Early nuclear protein HWLF1 (Tegument protein US22)
US33_HCMVA Uncharacterized protein HHLF3
VPAP_HCMVA DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
US18_HCMVA Transmembrane protein US18
US24_HCMVA Tegument protein US24 (Protein HHLF6)
VIE1_HCMVA 55 kDa immediate-early protein 1 (IE1)
VP22_HCMVA Protein UL24
UL03_HCMVA Uncharacterized protein UL3
UL09_HCMVA Uncharacterized protein UL9
UL101_HCMVA Uncharacterized protein UL101
UL106_HCMVA Uncharacterized protein UL106
UL107_HCMVA Uncharacterized protein UL107
UL108_HCMVA Uncharacterized protein UL108
UL121_HCMVA Membrane protein UL121
UL128_HCMVA Uncharacterized protein UL128
UL132_HCMVA Envelope glycoprotein UL132 (L3)
UL119_HCMVA Viral Fc-gamma receptor-like protein UL119 (gp68)
UL11P_HCMVA Protein UL11
UL129_HCMVA Uncharacterized protein UL129
UL12_HCMVA Uncharacterized protein UL12
UL130_HCMVA Uncharacterized protein UL130
UL13_HCMVA Uncharacterized protein UL13
UL21A_HCMVA Uncharacterized protein UL21A
UL22A_HCMVA Glycoprotein UL22A
UL23_HCMVA Tegument protein UL23
UL26_HCMVA Tegument protein UL26
UL27_HCMVA Protein UL27
UL28_HCMVA Uncharacterized protein UL28
UL29_HCMVA Uncharacterized protein UL29
UL30_HCMVA Uncharacterized protein UL30
UL66_HCMVA Uncharacterized protein UL66
UL67_HCMVA Uncharacterized protein UL67
UL68_HCMVA Uncharacterized protein UL68
UL01_HCMVA Glycoprotein UL1
UL02_HCMVA Uncharacterized protein UL2
UL120_HCMVA Uncharacterized protein UL120
UL18_HCMVA Glycoprotein UL18
UL20_HCMVA Uncharacterized protein UL20
UL35_HCMVA Protein UL35
UL52_HCMVA Packaging protein UL32 homolog (Protein HFRF1)
UL58_HCMVA Uncharacterized protein UL58
UL63_HCMVA Uncharacterized protein UL63
UL64_HCMVA Uncharacterized protein UL64
UL65_HCMVA Uncharacterized protein UL65
UL90_HCMVA Uncharacterized protein UL90
UL91_HCMVA Protein UL91
UL07_HCMVA CEACAM1-like protein UL7
UL08_HCMVA Membrane protein UL8
UL110_HCMVA Uncharacterized protein UL110
UL116_HCMVA Uncharacterized protein UL116
UL125_HCMVA Uncharacterized protein UL125
UL126_HCMVA Uncharacterized protein UL126
UL15A_HCMVA Uncharacterized protein UL15A
UL16P_HCMVA Protein UL16
UL17_HCMVA Uncharacterized protein UL17
UL21_HCMVA Uncharacterized protein UL21
UL31_HCMVA Protein UL31
UL33_HCMVA G-protein coupled receptor homolog UL33 (vGPCR UL33)
UL42_HCMVA Uncharacterized protein UL42
UL59_HCMVA Uncharacterized protein UL59
UL60_HCMVA Uncharacterized protein UL60
UL61_HCMVA Uncharacterized protein UL61
UL62_HCMVA Uncharacterized protein UL62
UL87_HCMVA Protein UL87
UL05_HCMVA Protein UL5
UL06_HCMVA Uncharacterized protein UL6
UL43_HCMVA Tegument protein UL43
UL49_HCMVA Uncharacterized protein UL49 (Protein HFLF5)
UL81_HCMVA Uncharacterized protein UL81
UL84_HCMVA Protein UL84
UL95_HCMVA Protein UL95
UL96_HCMVA Protein UL96
UL127_HCMVA Uncharacterized protein UL127
UL131_HCMVA Uncharacterized protein UL131
UL34_HCMVA Transcriptional regulator UL34
UL36_HCMVA Uncharacterized protein UL36
UL41A_HCMVA Protein UL41A
UL41_HCMVA Uncharacterized protein UL41
UL76_HCMVA Protein UL76
UL79_HCMVA Protein UL79
UL88_HCMVA Protein UL88
TEG7_HCMVA Tegument protein UL51 homolog
TRM3_HCMVA Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
CVC1_HCMVA Capsid vertex component 1
CVC2_HCMVA Capsid vertex component 2
CEP3_HCMVA Cytoplasmic envelopment protein 3
CEP1_HCMVA Cytoplasmic envelopment protein 1
DPOL_HCMVA DNA polymerase catalytic subunit (EC 2.7.7.7)
NEC2_HCMVA Nuclear egress protein 2
PP150_HCMVA Large structural phosphoprotein (150 kDa matrix phosphoprotein) (150 kDa phosphoprotein) (pp150) ...
PORTL_HCMVA Portal protein
PP85_HCMVA Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
RIR1_HCMVA Ribonucleoside-diphosphate reductase large subunit-like protein
AN_HCMVA Alkaline nuclease (EC 3.1.-.-)
IRS1_HCMVA Protein IRS1 (HQRF1)
GN_HCMVA Envelope glycoprotein N
GH_HCMVA Envelope glycoprotein H (gH)
ICP27_HCMVA mRNA export factor ICP27 homolog
GB_HCMVA Envelope glycoprotein B (gB)
IR01_HCMVA Uncharacterized protein HKLF1 (IRL1) (TRL1)
IR02_HCMVA Uncharacterized protein IRL2 (TRL2)
IR03_HCMVA Uncharacterized protein IRL3 (TRL3)
IR04_HCMVA Uncharacterized protein IRL4 (TRL4)
IR05_HCMVA Uncharacterized protein IRL5 (TRL5)
IR06_HCMVA Uncharacterized protein IRL6 (TRL6)
IR07_HCMVA Uncharacterized protein IRL7 (TRL7)
IR08_HCMVA Uncharacterized protein IRL8 (TRL8)
IR09_HCMVA Uncharacterized protein IRL9 (TRL9)
IR10_HCMVA Protein IRL10 (TRL10)
IR11_HCMVA Viral Fc-gamma receptor-like protein IR11 (gp34)
IR12_HCMVA Uncharacterized protein IRL12 (TRL12)
IR13_HCMVA Uncharacterized protein IRL13 (TRL13)
IR14_HCMVA Uncharacterized protein IRL14
GO_HCMVA Glycoprotein O (gO)
GL_HCMVA Envelope glycoprotein L (gL)
CEP2_HCMVA Cytoplasmic envelopment protein 2
DUT_HCMVA Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
EP84_HCMVA Early phosphoprotein p84 [Cleaved into: p20; p26; p28]
HELI_HCMVA DNA replication helicase (EC 3.6.4.-)
HEPA_HCMVA DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GM_HCMVA Envelope glycoprotein M (gM)

166 entries

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

Select_allDeselect_all
U131A_HCMVM Protein UL131A
U147A_HCMVM Uncharacterized protein UL147A
U148A_HCMVM Protein UL148A
U148B_HCMVM Protein UL148B
U148C_HCMVM Protein UL148C
U148D_HCMVM Protein UL148D
U150A_HCMVM Uncharacterized protein UL150A
TRS1_HCMVM Protein TRS1
TRX1_HCMVM Triplex capsid protein 1
UL06_HCMVM Uncharacterized protein UL6
UL117_HCMVM Protein UL117 (pUL117)
UL119_HCMVM Viral Fc-gamma receptor-like protein UL119 (gp68)
UL121_HCMVM Membrane protein UL121
UL132_HCMVM Envelope glycoprotein UL132
UL140_HCMVM Protein UL140
UL14_HCMVM Uncharacterized protein UL14
UL150_HCMVM Uncharacterized protein UL150
UL16P_HCMVM Protein UL16
UL18_HCMVM Membrane glycoprotein UL18
UL19_HCMVM Uncharacterized protein UL19
UL20_HCMVM Membrane protein UL20
UL35_HCMVM Tegument protein UL35
UL87_HCMVM Uncharacterized protein UL87
UL92_HCMVM Uncharacterized protein UL92
LTP_HCMVM Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
ITP_HCMVM Inner tegument protein
IL10H_HCMVM Viral interleukin-10 homolog (cmvIL-10) (vIL-10)
MCP_HCMVM Major capsid protein (MCP)
NEC1_HCMVM Nuclear egress protein 1
RL12_HCMVM Uncharacterized protein RL12
RL13_HCMVM Membrane protein RL13
PRIM_HCMVM DNA primase (EC 2.7.7.-)
PP71_HCMVM Protein pp71
RL11_HCMVM Membrane glycoprotein RL11
SCAF_HCMVM Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
SCP_HCMVM Small capsomere-interacting protein
TRX2_HCMVM Triplex capsid protein 2
US02_HCMVM Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US15_HCMVM Membrane protein US15
US33A_HCMVM Uncharacterized protein US33A
UL97_HCMVM Serine/threonine protein kinase UL97 (EC 2.7.1.-)
TRM3_HCMVM Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
US32_HCMVM Protein US32
US03_HCMVM Membrane glycoprotein US3
US23_HCMVM Protein US23
US26_HCMVM Protein US26
US27_HCMVM Envelope glycoprotein US27
US28_HCMVM Envelope protein US28
US30_HCMVM Uncharacterized protein US30
US31_HCMVM Uncharacterized protein US31
UNG_HCMVM Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
US08_HCMVM Membrane glycoprotein US8
US17_HCMVM Protein US17
US13_HCMVM Membrane protein US13
US21_HCMVM Membrane protein US21
US22_HCMVM Tegument protein US22
US09_HCMVM Membrane glycoprotein US9
US10_HCMVM Membrane glycoprotein US10
US11_HCMVM Membrane glycoprotein US11
US29_HCMVM Uncharacterized protein US29
US34A_HCMVM Uncharacterized protein US34A
US20_HCMVM Membrane protein US20
VICA_HCMVM Viral inhibitor of caspase-8-induced apoptosis (vICA)
VIE2_HCMVM Viral transcription factor IE2 (IE2) (Protein UL122)
VGLI_HCMVM UL37 immediate early glycoprotein
US07_HCMVM Membrane glycoprotein US7
US12_HCMVM Uncharacterized protein US12
US34_HCMVM Protein US34
US19_HCMVM Transmembrane protein US19
US06_HCMVM Unique short US6 glycoprotein
US01_HCMVM Protein US1
US16_HCMVM Protein US16
US18_HCMVM Transmembrane protein US18
US14_HCMVM Membrane protein US14
US24_HCMVM Tegument protein US24
VIE1_HCMVM 55 kDa immediate-early protein 1
VP22_HCMVM Tegument protein UL24
UL02_HCMVM Uncharacterized protein UL2
UL09_HCMVM Membrane glycoprotein UL9
UL11P_HCMVM Protein UL11
UL136_HCMVM Protein UL136
UL141_HCMVM Protein UL141
UL13_HCMVM Uncharacterized protein UL13
UL22A_HCMVM Glycoprotein UL22A
UL23_HCMVM Tegument protein UL23
UL26_HCMVM Tegument protein UL26
UL27_HCMVM Protein UL27
UL298_HCMVM Protein UL29/28
UL30_HCMVM Uncharacterized protein UL30
UL40_HCMVM Protein UL40
UL139_HCMVM Membrane glycoprotein UL139
UL52_HCMVM Packaging protein UL32 homolog
UL74A_HCMVM Uncharacterized protein UL74A
UL76_HCMVM Protein UL76
UL78_HCMVM Protein UL78
UL88_HCMVM Protein UL88
UL91_HCMVM Protein UL91
UL01_HCMVM Glycoprotein UL1
UL07_HCMVM CEACAM1-like protein UL7
UL133_HCMVM Protein UL133
UL138_HCMVM Protein UL138
UL10_HCMVM Uncharacterized protein UL10
UL124_HCMVM Uncharacterized protein UL124
UL145_HCMVM Protein UL145
UL148_HCMVM Membrane protein UL148
UL17_HCMVM Protein UL17
UL21A_HCMVM Uncharacterized protein UL21A
UL31_HCMVM Protein UL31
UL84_HCMVM Protein UL84
UL04_HCMVM Envelope glycoprotein UL4
UL130_HCMVM Envelope glycoprotein UL130
UL135_HCMVM Protein UL135
UL142_HCMVM Membrane glycoprotein UL142
UL144_HCMVM Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
UL147_HCMVM Putative viral CXC chemokine 2 (vCXCL2)
UL15A_HCMVM Uncharacterized protein UL15A
UL42_HCMVM Protein UL42
UL43_HCMVM Tegument protein UL43
UL49_HCMVM Protein UL49
UL95_HCMVM Protein UL95
UL96_HCMVM Protein UL96
UL05_HCMVM Protein UL5
UL116_HCMVM Uncharacterized protein UL116
UL120_HCMVM Membrane protein UL120
UL33_HCMVM G-protein coupled receptor homolog UL33
UL34_HCMVM Transcriptional regulator UL34
UL38_HCMVM Apoptosis inhibitor UL38
UL41A_HCMVM Protein UL41A
UL79_HCMVM Protein UL79
TEG7_HCMVM Tegument protein UL51 homolog
VPAP_HCMVM DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)
TRM1_HCMVM Tripartite terminase subunit 1
TRM2_HCMVM Tripartite terminase subunit 2
CXCL1_HCMVM Chemokine vCXCL1
CVC2_HCMVM Capsid vertex component 2
CVC1_HCMVM Capsid vertex component 1
CEP3_HCMVM Cytoplasmic envelopment protein 3 (28 kDa structural phosphoprotein) (pp28)
DPOL_HCMVM DNA polymerase catalytic subunit (EC 2.7.7.7)
NEC2_HCMVM Nuclear egress protein 2
PP150_HCMVM Tegument protein pp150
RL5A_HCMVM Protein RL5A
PP65_HCMVM 65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein ...
PORTL_HCMVM Portal protein
PP85_HCMVM Phosphoprotein 85 (pp85) (Phosphoprotein UL25)
RIR1_HCMVM Ribonucleoside-diphosphate reductase large subunit-like protein
RL8A_HCMVM Protein RL8A
RL9A_HCMVM Protein RL9A
AN_HCMVM Alkaline nuclease (EC 3.1.-.-)
GH_HCMVM Envelope glycoprotein H (gH)
GB_HCMVM Envelope glycoprotein B (gB)
ICP27_HCMVM mRNA export factor ICP27 homolog
GN_HCMVM Envelope glycoprotein N
GO_HCMVM Envelope glycoprotein O
IR01_HCMVM Uncharacterized protein HKLF1 (IRL1) (TRL1)
IR06_HCMVM Uncharacterized protein IRL6 (TRL6)
IR10_HCMVM Protein IRL10 (TRL10)
IRS1_HCMVM Protein IRS1
GL_HCMVM Envelope glycoprotein L (gL)
DUT_HCMVM Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
CEP1_HCMVM Cytoplasmic envelopment protein 1
CEP2_HCMVM Cytoplasmic envelopment protein 2
EP84_HCMVM Early phosphoprotein p84
DNBI_HCMVM Major DNA-binding protein
HELI_HCMVM DNA replication helicase (EC 3.6.4.-)
HEPA_HCMVM DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
GM_HCMVM Envelope glycoprotein M (gM)

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)

UL298_HCMVA Protein UL29/UL28

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

UL128_HCMVM Envelope protein UL128

11 entries

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Select_allDeselect_all
LTP_HCMVT Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
PRIM_HCMVT DNA primase (EC 2.7.7.-)
VIE2_HCMVT Viral transcription factor IE2 (IE2) (Protein UL122)
US03_HCMVT Membrane glycoprotein US3
UL132_HCMVT Envelope glycoprotein UL132 (L3)
UL17_HCMVT Protein UL17
UL135_HCMVT Protein UL135
UL147_HCMVT Putative viral CXC chemokine 2 (vCXCL2)
UL136_HCMVT Protein UL136
UL34_HCMVT Transcriptional regulator UL34
UL95_HCMVT Protein UL95

1 entry

Human cytomegalovirus (strain Toledo) (HHV-5) (Human herpesvirus 5)

UL144_HCMVO Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)