Lyssavirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

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Matching UniProtKB/Swiss-Prot entries

108 entries grouped by strain (browse by keywords)

All proteins are shown (view only 91 complete proteome entries)

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

Select_allDeselect_all
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVB Glycoprotein
L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVB Matrix protein (Phosphoprotein M2)

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

Select_allDeselect_all
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)
GLYCO_EBLV1 Glycoprotein
MATRX_EBLV1 Matrix protein
L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

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PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_EBLV2 Matrix protein
GLYCO_EBLV2 Glycoprotein

5 entries

Mokola virus (MOKV) reference strain

Select_allDeselect_all
NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_MOKV Glycoprotein
L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_MOKV Matrix protein (Phosphoprotein M2)

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

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NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVP Glycoprotein
L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVP Matrix protein (Phosphoprotein M2)

4 entries

Aravan virus (ARAV) reference strain

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PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_ARAV Glycoprotein
MATRX_ARAV Matrix protein (Phosphoprotein M2)

6 entries

Rabies virus (strain PM1503/AVO1) (RABV)

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PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
C_RABVA Putative uncharacterized protein C
L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVA Matrix protein (Phosphoprotein M2)
GLYCO_RABVA Glycoprotein

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

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NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_ABLVH Glycoprotein

5 entries

Rabies virus (strain China/DRV) (RABV)

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NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVD Matrix protein (Phosphoprotein M2)
GLYCO_RABVD Glycoprotein

5 entries

Rabies virus (strain China/MRV) (RABV)

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NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVR Glycoprotein
L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVR Matrix protein (Phosphoprotein M2)

5 entries

Rabies virus (strain ERA) (RABV)

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PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVE Matrix protein (Phosphoprotein M2)
GLYCO_RABVE Glycoprotein

5 entries

Rabies virus (strain HEP-Flury) (RABV)

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NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)
L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVH Matrix protein (Phosphoprotein M2)
GLYCO_RABVH Glycoprotein

5 entries

Rabies virus (strain India) (RABV)

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NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)
MATRX_RABVI Matrix protein (Phosphoprotein M2)
L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVI Glycoprotein

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

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NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)
L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVN Matrix protein (Phosphoprotein M2)
GLYCO_RABVN Glycoprotein

5 entries

Rabies virus (strain SAD B19) (RABV)

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NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVS Glycoprotein
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVS Matrix protein (Phosphoprotein M2)

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

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PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVB Glycoprotein
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVB Matrix protein (Phosphoprotein M2)

4 entries

Irkut virus (IRKV)

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NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_IRKV Glycoprotein
MATRX_IRKV Matrix protein (Phosphoprotein M2)

4 entries

Khujand virus (KHUV)

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PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_KHUV Matrix protein (Phosphoprotein M2)
GLYCO_KHUV Glycoprotein

4 entries

Lagos bat virus (LBV)

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PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)
NCAP_LBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_LBV Glycoprotein
MATRX_LBV Matrix protein

4 entries

Rabies virus (strain CVS-11) (RABV)

Select_allDeselect_all
PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVC Matrix protein (Phosphoprotein M2)
GLYCO_RABVC Glycoprotein

4 entries

West Caucasian bat virus (WCBV)

Select_allDeselect_all
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)
GLYCO_WCBV Glycoprotein
MATRX_WCBV Matrix protein (Phosphoprotein M2)

3 entries

Duvenhage virus (DUVV)

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NCAP_DUVV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)
GLYCO_DUVV Glycoprotein

1 entry

Rabies virus (isolate Fox/Ontario/1991) (RABV)

NCAP_RABVF Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (isolate Human/Algeria/1991) (RABV)

GLYCO_RABVT Glycoprotein

1 entry

Rabies virus (isolate Skunk/Ontario/1991) (RABV)

NCAP_RABVU Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Vnukovo-32) (RABV)

GLYCO_RABVV Glycoprotein