Lyssavirus (taxid:11286)

Lyssavirus is a genus of ssRNA- viruses in the family Rhabdoviridae that infect neurons of mammals. Rabies virus (RabV) infections in humans are associated with Rabies fatal encephalitis.

VIRION

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Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

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Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

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Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

108 entries grouped by strain

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

Select_allDeselect_all
L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVB Glycoprotein
MATRX_ABLVB Matrix protein (Phosphoprotein M2)
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

Select_allDeselect_all
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)
L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYCO_EBLV1 Glycoprotein
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV1 Matrix protein

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

Select_allDeselect_all
PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)
GLYCO_EBLV2 Glycoprotein
L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_EBLV2 Matrix protein

5 entries

Mokola virus (MOKV) reference strain

Select_allDeselect_all
L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)
NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_MOKV Matrix protein (Phosphoprotein M2)
GLYCO_MOKV Glycoprotein

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

Select_allDeselect_all
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)
L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVP Glycoprotein
MATRX_RABVP Matrix protein (Phosphoprotein M2)

4 entries

West Caucasian bat virus (WCBV) reference strain

Select_allDeselect_all
PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)
GLYCO_WCBV Glycoprotein
MATRX_WCBV Matrix protein (Phosphoprotein M2)
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

6 entries

Rabies virus (strain PM1503/AVO1) (RABV)

Select_allDeselect_all
PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)
L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVA Glycoprotein
MATRX_RABVA Matrix protein (Phosphoprotein M2)
C_RABVA Putative uncharacterized protein C

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

Select_allDeselect_all
L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVH Glycoprotein
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain China/DRV) (RABV)

Select_allDeselect_all
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVD Glycoprotein
MATRX_RABVD Matrix protein (Phosphoprotein M2)
NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain China/MRV) (RABV)

Select_allDeselect_all
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)
L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVR Glycoprotein
MATRX_RABVR Matrix protein (Phosphoprotein M2)
NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain ERA) (RABV)

Select_allDeselect_all
PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)
L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVE Glycoprotein
MATRX_RABVE Matrix protein (Phosphoprotein M2)
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain HEP-Flury) (RABV)

Select_allDeselect_all
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)
L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVH Glycoprotein
MATRX_RABVH Matrix protein (Phosphoprotein M2)
NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain India) (RABV)

Select_allDeselect_all
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)
L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVI Matrix protein (Phosphoprotein M2)
GLYCO_RABVI Glycoprotein

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

Select_allDeselect_all
L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)
MATRX_RABVN Matrix protein (Phosphoprotein M2)
GLYCO_RABVN Glycoprotein
NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Rabies virus (strain SAD B19) (RABV)

Select_allDeselect_all
PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)
MATRX_RABVS Matrix protein (Phosphoprotein M2)
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVS Glycoprotein

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

Select_allDeselect_all
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVB Glycoprotein
MATRX_RABVB Matrix protein (Phosphoprotein M2)
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Aravan virus (ARAV)

Select_allDeselect_all
PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)
GLYCO_ARAV Glycoprotein
MATRX_ARAV Matrix protein (Phosphoprotein M2)
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Irkut virus (IRKV)

Select_allDeselect_all
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_IRKV Glycoprotein
MATRX_IRKV Matrix protein (Phosphoprotein M2)
NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Khujand virus (KHUV)

Select_allDeselect_all
PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)
GLYCO_KHUV Glycoprotein
MATRX_KHUV Matrix protein (Phosphoprotein M2)
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Lagos bat virus (LBV)

Select_allDeselect_all
PHOSP_LBV Phosphoprotein (Protein P) (Protein M1)
MATRX_LBV Matrix protein
NCAP_LBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_LBV Glycoprotein

4 entries

Rabies virus (strain CVS-11) (RABV)

Select_allDeselect_all
PHOSP_RABVC Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVC Glycoprotein
MATRX_RABVC Matrix protein (Phosphoprotein M2)
NCAP_RABVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

3 entries

Duvenhage virus (DUVV)

Select_allDeselect_all
PHOSP_DUVV Phosphoprotein (Protein P) (Protein M1)
NCAP_DUVV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_DUVV Glycoprotein

1 entry

Rabies virus (isolate Fox/Ontario/1991) (RABV)

NCAP_RABVF Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (isolate Human/Algeria/1991) (RABV)

GLYCO_RABVT Glycoprotein

1 entry

Rabies virus (isolate Skunk/Ontario/1991) (RABV)

NCAP_RABVU Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

1 entry

Rabies virus (strain PM) (RABV)

PHOSP_RABVM Phosphoprotein (Protein P) (Protein M1)

1 entry

Rabies virus (strain Vnukovo-32) (RABV)

GLYCO_RABVV Glycoprotein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Australian bat lyssavirus (isolate Bat/AUS/1996) taxid:446561

Protein ModelArchive
Glycoprotein ma-jd-viral-07136
Matrix protein (Phosphoprotein M2) ma-jd-viral-62210
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15325
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47500

Duvenhage virus taxid:38767

Protein ModelArchive
Glycoprotein ma-jd-viral-07146
Matrix protein ma-jd-viral-62216
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15316
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15316
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47504
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47504

European bat lyssavirus 1 taxid:57482

Protein ModelArchive
Glycoprotein ma-jd-viral-07147
Glycoprotein ma-jd-viral-07147
Matrix protein ma-jd-viral-62213
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15324
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47499

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) taxid:453115

Protein ModelArchive
Glycoprotein ma-jd-viral-07147
Matrix protein ma-jd-viral-62213
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15324
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47499

European bat lyssavirus 2 taxid:57483

Protein ModelArchive
Glycoprotein ma-jd-viral-07135
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47494

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) taxid:453116

Protein ModelArchive
Glycoprotein ma-jd-viral-07135
Matrix protein ma-jd-viral-62219
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15315
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47494

Gannoruwa bat lyssavirus taxid:1846259

Protein ModelArchive
Glycoprotein ma-jd-viral-07145
Matrix protein ma-jd-viral-62212
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15326
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47497

Ikoma lyssavirus taxid:1167696

Protein ModelArchive
Glycoprotein ma-jd-viral-07138
Matrix protein ma-jd-viral-62214
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15323
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47498

Lagos bat virus taxid:38766

Protein ModelArchive
Glycoprotein ma-jd-viral-07144
Matrix protein ma-jd-viral-62211
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15317
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47501

Lleida bat lyssavirus taxid:1213198

Protein ModelArchive
Glycoprotein ma-jd-viral-07141
Matrix protein ma-jd-viral-62218
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15319
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47492

Lyssavirus bokeloh taxid:1072176

Protein ModelArchive
Glycoprotein ma-jd-viral-07142
Matrix protein ma-jd-viral-62217
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15322
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47496

Lyssavirus rabies taxid:11292

Protein ModelArchive
Glycoprotein ma-jd-viral-07137

Lyssavirus shimoni taxid:746543

Protein ModelArchive
Glycoprotein ma-jd-viral-07148
Matrix protein ma-jd-viral-62221
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15321
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47493

Mokola virus taxid:12538

Protein ModelArchive
Glycoprotein ma-jd-viral-07139
Glycoprotein ma-jd-viral-07139
Matrix protein ma-jd-viral-62222
Matrix protein ma-jd-viral-62222
Matrix protein (Phosphoprotein M2) ma-jd-viral-62222
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15318
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15318
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15318
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47502
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47502

Rabies virus (strain Pasteur vaccins / PV) taxid:103929

Protein ModelArchive
Glycoprotein ma-jd-viral-07137
Matrix protein (Phosphoprotein M2) ma-jd-viral-62220
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15314
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-47503