Lyssavirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins, plus 4 by alternative initiation.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Inhibition of T-cell response

Rabies nucleoprotein may act as a superantigen by inhibiting Vbeta T-Cell repertoire

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Matching UniProtKB/Swiss-Prot entries

91 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 108 entries)

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

Select_allDeselect_all
L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVB Matrix protein (Phosphoprotein M2)
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVB Glycoprotein

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

Select_allDeselect_all
L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_EBLV1 Matrix protein
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_EBLV1 Glycoprotein

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

Select_allDeselect_all
L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_EBLV2 Matrix protein
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)
GLYCO_EBLV2 Glycoprotein

5 entries

Mokola virus (MOKV) reference strain

Select_allDeselect_all
L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_MOKV Matrix protein (Phosphoprotein M2)
NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_MOKV Glycoprotein

5 entries

Rabies virus (strain China/DRV) (RABV) reference strain

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MATRX_RABVD Matrix protein (Phosphoprotein M2)
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVD Glycoprotein

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

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MATRX_RABVP Matrix protein (Phosphoprotein M2)
L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVP Glycoprotein

5 entries

Rabies virus (strain SAD B19) (RABV) reference strain

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MATRX_RABVS Matrix protein (Phosphoprotein M2)
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVS Glycoprotein

4 entries

Irkut virus (IRKV) reference strain

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MATRX_IRKV Matrix protein (Phosphoprotein M2)
NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_IRKV Glycoprotein

4 entries

West Caucasian bat virus (WCBV) reference strain

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PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_WCBV Matrix protein (Phosphoprotein M2)
GLYCO_WCBV Glycoprotein

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

Select_allDeselect_all
L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVH Glycoprotein

5 entries

Rabies virus (strain China/MRV) (RABV)

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MATRX_RABVR Matrix protein (Phosphoprotein M2)
L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVR Glycoprotein

5 entries

Rabies virus (strain ERA) (RABV)

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L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVE Matrix protein (Phosphoprotein M2)
PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVE Glycoprotein

5 entries

Rabies virus (strain HEP-Flury) (RABV)

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L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVH Matrix protein (Phosphoprotein M2)
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVH Glycoprotein

5 entries

Rabies virus (strain India) (RABV)

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L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVI Matrix protein (Phosphoprotein M2)
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVI Glycoprotein

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

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L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVN Matrix protein (Phosphoprotein M2)
NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVN Glycoprotein

5 entries

Rabies virus (strain PM1503/AVO1) (RABV)

Select_allDeselect_all
NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVA Matrix protein (Phosphoprotein M2)
L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVA Glycoprotein
PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

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MATRX_RABVB Matrix protein (Phosphoprotein M2)
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVB Glycoprotein
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Aravan virus (ARAV)

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GLYCO_ARAV Glycoprotein
PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)
MATRX_ARAV Matrix protein (Phosphoprotein M2)
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Khujand virus (KHUV)

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MATRX_KHUV Matrix protein (Phosphoprotein M2)
PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_KHUV Glycoprotein