Emesvirus (taxid:2842664)

(formerly named Levivirus)

VIRION

image

Non-enveloped, spherical virion about 26 nm in diameter with T=3 icosahedral symmetry composed of 178 CP proteins and a single A maturation protein .
image PBDe

GENOME

image

Monopartite, linear, ssRNA(+) genome about 3.5 kb in size. The 5' end is a triphosphate. Encodes 4 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Encodes for 4 ORFs. Cp protein repress replicase translation by binding a RNA hairpin at the start site of this gene.

ENZYMES

REPLICATION

  1. Adsorption to F pili of target cells induces cleavage and release of A maturation protein.
  2. Genomic RNA enters the bacterium.
  3. Viral proteins are translated.
  4. Viral replicase assembles with host proteins (ribosomal protein S1, translation elongation factors EF-Tu and EF-Ts) to form the active RNA polymerase.
  5. Replication of genomic RNA into a minus strand, which serves as template to produce new positive strand genomes.
  6. Late in infection CP protein bind to a RNA hairpin on the genome, and new virus particles are assembled in the cytoplasm.
  7. Release by cell lysis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

17 entries grouped by protein

7 entries

Capsid protein (CP) (Coat protein)

Select_allDeselect_all
CAPSD_BPGA
Enterobacteria phage GA (Bacteriophage GA) reference strain
CAPSD_BPMS2
Escherichia phage MS2 (Bacteriophage MS2) reference strain
CAPSD_BPF2
Enterobacteria phage f2 (Bacteriophage f2)
CAPSD_BPFR
Enterobacteria phage fr (Bacteriophage fr)
CAPSD_BPJP3
Enterobacteria phage JP34 (Bacteriophage JP34)
CAPSD_BPR17
Enterobacteria phage R17 (Bacteriophage R17)
CAPSD_BPZR
Enterobacteria phage ZR (Bacteriophage ZR)

4 entries

Lysis protein

Select_allDeselect_all
LYS_BPGA
Enterobacteria phage GA (Bacteriophage GA) reference strain
LYS_BPMS2
Escherichia phage MS2 (Bacteriophage MS2) reference strain

Lysis protein (L protein)

LYS_BPFR
Enterobacteria phage fr (Bacteriophage fr)
LYS_BPJP3
Enterobacteria phage JP34 (Bacteriophage JP34)

3 entries

Maturation protein A (MP) (Assembly protein) (A protein)

Select_allDeselect_all
MATA_BPGA
Enterobacteria phage GA (Bacteriophage GA) reference strain
MATA_BPMS2
Escherichia phage MS2 (Bacteriophage MS2) reference strain
MATA_BPFR
Enterobacteria phage fr (Bacteriophage fr)

3 entries

RNA-directed RNA polymerase beta chain (EC 2.7.7.48) (RNA replicase beta chain)

Select_allDeselect_all
RDRP_BPGA
Enterobacteria phage GA (Bacteriophage GA) reference strain
RDRP_BPMS2
Escherichia phage MS2 (Bacteriophage MS2) reference strain
RDRP_BPFR
Enterobacteria phage fr (Bacteriophage fr)