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Caliciviridae (taxid:11974)

VIRION

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Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.
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GENOME

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Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genome encodes a polyprotein (ORF1). One or two smaller ORFs are expressed from a subgenomic RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. The 3'-end terminal ORF encodes a basic protein (and the capsid protein) and is expressed through RNA termination-reinitiation.
Some Norovirus expressan alternative ORF by leaky scanning Vesiviruses are apparently unique among the Caliciviridae in that the ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.
DB LINKS image image

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image Calicivirus Typing tool
TAXONOMY Group IV; ssRNA positive-strand viruses
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family:Caliciviridae
Genus: Lagovirus
Nebovirus
Norovirus
Sapovirus
Vesivirus
ETYMOLOGY Calici: from Latin 'Cup?, referring to cup-shaped depressions that can be seen on some of these viruses.
VIRUS
Newbury 1 virus
 Norwalk virus
 Rabbit hemorrhagic disease virus
 Sapporo virus
 Vesicular exanthema of swine virus
 European brown hare syndrome virus
 Feline calicivirus
REFERENCE STRAINS Newbury-1 virus
Sequence | Genome assembly | Proteome
Norwalk virus
Sequence | Genome assembly | Proteome
Rabbit haemorrhagic disease virus
Sequence | Genome assembly | Proteome
Sapovirus Hu/Dresden/pJG-Sap01/DE
Sequence | Genome assembly | Proteome
Vesicular exanthema of swine virus
Sequence | Genome assembly | Proteome
Feline calicivirus
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS vertebrates.
TROPISM
INTERACTIONS Cell receptors: -
Host-virus interaction

Ecology and diseasey

GEOGRAPHY Worldwide.
ASSOCIATED DISEASES Feline calicivirus: respiratory disease.
Rabbit hemorrhagic disease virus: often-fatal hemorrhages.
Norwalk group of viruses: gastroenteritis.
TRANSMISSION Fecal-oral.
VACCINE
ANTIVIRAL DRUGS

Host-virus interaction

Apoptosis modulation

Murine norovirus and rabbit hemorrhagic disease virus induce host cell apoptosis .

Host gene expression shutoff by virus

Noroviruses and Vesiviruses mediate host translation shutoff by cleaving PABP1 .

GENERAL Back to caliciviridae page
NATURAL HOSTS vertebrates.
TROPISM
INTERACTIONS Cell receptors: -
ASSOCIATED DISEASES Feline calicivirus: respiratory disease.
Rabbit hemorrhagic disease virus: often-fatal hemorrhages.
Norwalk group of viruses: gastroenteritis.
TRANSMISSION Fecal-oral.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

60 entries grouped by protein

13 entries

Capsid protein VP1 (CP) (Capsid protein) (Coat protein)

Select_allDeselect_all
CAPSD_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa)

CAPSD_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain

Capsid protein VP1 (CP) (Coat protein) (p59)

pdb 1IHM; 2ZL5; 2ZL6; 2ZL7; 3BY1; 3BY2; 3D26; 5KW9; 5N7M; 6CRJ; 6H6Y; 6H6Z; 6H70; 6H71; 6H72; 6OUT; 7KJP

CAPSD_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain
CAPSD_CACV4
Canine calicivirus (strain 48) (CaCV)
CAPSD_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)

Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa)

CAPSD_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)

Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa)

CAPSD_FCVF9
Feline calicivirus (strain F9) (FCV)

Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa)

pdb 6GSI

CAPSD_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Capsid protein VP1 (CP) (Coat protein) (VP1)

CAPSD_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)

Capsid protein VP1 (CP) (Coat protein)

pdb 6C6Q; 6CRJ; 6E47; 6E48; 6XW4; 6XW5; 6XW6; 6XW7; 7N6Y; 7N7F

CAPSD_RHDVR
Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)

Subgenomic capsid protein VP60

CAPSD_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)
CAPSD_SMSV4
San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)

pdb 2GH8

CAPSD_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Capsid protein VP1 (CP) (Coat protein)

24 entries

Genome polyprotein (p254)

Select_allDeselect_all
POLG_BECN1
Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain

Genome polyprotein

POLG_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Genome polyprotein

POLG_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain

Genome polyprotein

pdb 2FYQ; 2FYR; 2LNC; 3UR6; 3UR9; 4IMQ; 4IMZ; 4IN1; 4IN2; 4INH; 4XBB; 4XBC; 4XBD; 5DG6; 5DGJ; 5E0G; 5E0H; 5E0J; 5T6D; 5T6F; 5T6G; 5TG1; 5TG2; 5WEJ; 6BIB; 6BIC; 6BID; 6W5H; 6W5J; 6W5K; 6W5L; 9D9Y

POLG_RHDVF
Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain

pdb 1KHV; 1KHW; 6M24; 6M2J; 6M2K

POLG_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain

Genome polyprotein

POLG_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Genome polyprotein

POLG_BECNB
Bovine enteric calicivirus NB (isolate Bovine/United States/N ebraska/1980) (BEC-NB)

Genome polyprotein

POLG_CACV4
Canine calicivirus (strain 48) (CaCV)

Genome polyprotein

POLG_EBHSG
European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)
POLG_FCV
Feline calicivirus (FCV)

Genome polyprotein

POLG_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)

Genome polyprotein

POLG_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)

Genome polyprotein

POLG_FCVF9
Feline calicivirus (strain F9) (FCV)

Genome polyprotein

pdb 2M4H

POLG_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Genome polyprotein

POLG_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)

Genome polyprotein

pdb 2M4G; 2MCD; 2MCH; 3NAH; 3NAI; 3QID; 3SFG; 3SFU; 3UPF; 3UQS; 3UR0; 4ASH; 4NRU; 4O4R; 4X2V; 4X2W; 4X2X; 4X2Y; 5Y3D; 8A5M; 8A8X

POLG_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)

Genome polyprotein

pdb 2MXD

POLG_RHDV3
Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)
POLG_RHDVA
Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)

pdb 3ZUE

POLG_RHDVB
Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)
POLG_RHDVS
Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)
POLG_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

Genome polyprotein

POLG_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Genome polyprotein

pdb 2IPH

POLG_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Genome polyprotein

POLG_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

Genome polyprotein

pdb 2CKW; 2UUT; 2UUW; 2WK4

1 entry

Virulence factor 1 (VF1)

VF1_MNV1
Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)

20 entries

Minor capsid protein VP2

Select_allDeselect_all
VP2_BECN1
Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain
VP2_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain
VP2_NVN68
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain
VP2_RHDVF
Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain
VP2_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP2_VESVA
Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain
VP2_BECNB
Bovine enteric calicivirus NB (isolate Bovine/United States/N ebraska/1980) (BEC-NB)
VP2_CACV4
Canine calicivirus (strain 48) (CaCV)
VP2_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)
VP2_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)
VP2_FCVF9
Feline calicivirus (strain F9) (FCV)

pdb 6GSI

VP2_LORDV
Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)
VP2_PESV
Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)
VP2_RHDV3
Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)
VP2_RHDVA
Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)
VP2_SMSV1
San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)
VP2_SMSV4
San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)
VP2_SOUV3
Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)
VP2_SVM10
Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)
VP2_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

2 entries

Uncharacterized protein VP3

Select_allDeselect_all
VP3_SVSAP
Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain
VP3_SVM93
Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Atlantic salmon calicivirus taxid:1489836

Protein ModelArchive
Putative minor structural protein ma-jd-viral-39815

Bat sapovirus TLC58/HK taxid:1185359

Protein ModelArchive
VP2 ma-jd-viral-58991

Bovine calicivirus strain Kirklareli taxid:1812179

Protein ModelArchive
Minor capsid protein ma-jd-viral-64752

Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) taxid:331642

Protein ModelArchive
Protein VP2 (Minor capsid VP2) ma-jd-viral-64753

Calicivirus isolate TCG taxid:243550

Protein ModelArchive
VP2 minor capsid protein ma-jd-viral-64751

Calicivirus pig/AB90/CAN taxid:520973

Protein ModelArchive
VP2 ma-jd-viral-60846

Chicken calicivirus taxid:1172196

Protein ModelArchive
VP2 ma-jd-viral-57104

Goose calicivirus taxid:1493858

Protein ModelArchive
Small basic protein ma-jd-viral-66524

Mink calicivirus taxid:154122

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52280
ORF3 protein ma-jd-viral-46038

Norovirus GIII taxid:340017

Protein ModelArchive
Capsid ma-jd-viral-54537
VP2 ma-jd-viral-36156

Rabbit calicivirus Australia 1 MIC-07 taxid:576948

Protein ModelArchive
Minor structural protein ma-jd-viral-67207

Rabbit vesivirus taxid:303317

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52281
Protein VP2 (Minor capsid protein) ma-jd-viral-31373

Sapovirus (strain GII/Human/Japan/Sakai C12/2001) taxid:290314

Protein ModelArchive
ORF2 protein ma-jd-viral-40101

Vesivirus ferret badger/JX12/China/2012 taxid:1615583

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52283
Protein VP2 (Minor capsid protein) ma-jd-viral-31374

Walrus calicivirus (isolate Walrus/Russia/7420/1977) taxid:146073

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52278
Protein VP2 (Minor capsid protein) ma-jd-viral-31372