Caliciviridae (taxid:11974)

VIRION

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Non-enveloped, capsid of about 27-40 nm in diameter, with T=3 icosahedral symmetry. The capsid is composed of 180 capsid proteins.
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GENOME

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Monopartite, linear ssRNA(+) genome of 7.3 to 8.3 kb. The 5'-terminus is linked to a VPg protein and the 3'-terminus has a poly(A) tract.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The genome encodes a polyprotein (ORF1). One or two smaller ORFs are expressed from a subgenomic RNA. Cleavage of ORF1 polyprotein by the virus-encoded 3C-like cysteine proteinase yields the mature nonstructural proteins. The 3'-end terminal ORF encodes a basic protein (and the capsid protein) and is expressed through RNA termination-reinitiation.
Some Norovirus expressan alternative ORF by leaky scanning Vesiviruses are apparently unique among the Caliciviridae in that the ORF2 encodes a capsid precursor protein that is proteolytically processed by the viral proteinase to yield the mature capsid protein.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors mediates endocytosis of the virus into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. VPg is removed from the viral RNA, which is then translated into a processed ORF1 polyprotein to yield the replication proteins.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
  7. Assembly of new virus particles and release by cell lysis.

Host-virus interaction

Apoptosis modulation

Murine norovirus and rabbit hemorrhagic disease virus induce host cell apoptosis .

Host gene expression shutoff by virus

Noroviruses and Vesiviruses mediate host translation shutoff by cleaving PABP1 .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

60 entries grouped by strain

3 entries

Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain

Select_allDeselect_all
POLG_FCVUR Genome polyprotein [Cleaved into: NS1 (Protein p5.6); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_FCVUR Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa) [Cleaved into: Capsid leader protein (LC) ...
VP2_FCVUR Minor capsid protein VP2

3 entries

Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) (Hu/NV/NV/1968/US) reference strain

Select_allDeselect_all
POLG_NVN68 Genome polyprotein [Cleaved into: NS1-2 (NS1.2) (NS1/2) (Protein p48); NS1; NS2; NTPase (EC ...
CAPSD_NVN68 Capsid protein VP1 (CP) (Coat protein) (p59) [Cleaved into: Soluble capsid protein (Protein 30k) ...
VP2_NVN68 Minor capsid protein VP2

3 entries

Sapporo virus (isolate GI/Human/Germany/pJG-Sap01) (Hu/Dresden/pJG-Sap01/DE) reference strain

Select_allDeselect_all
POLG_SVSAP Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC 3.6.1.15) (NS3) ...
VP2_SVSAP Minor capsid protein VP2
VP3_SVSAP Uncharacterized protein VP3

3 entries

Vesicular exanthema of swine virus serotype A48 (isolate Swine/United States/A48/1948) (VESV) reference strain

Select_allDeselect_all
POLG_VESVA Genome polyprotein [Cleaved into: NS1 (Protein p16); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_VESVA Capsid protein VP1 (CP) (Capsid protein) (Coat protein) [Cleaved into: Capsid leader protein (LC); ...
VP2_VESVA Minor capsid protein VP2

2 entries

Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) (BEC) reference strain

Select_allDeselect_all
POLG_BECN1 Genome polyprotein [Cleaved into: Protein p34; NTPase (EC 3.6.1.15) (p37); Protein p30; Viral ...
VP2_BECN1 Minor capsid protein VP2

2 entries

Rabbit hemorrhagic disease virus (strain Rabbit/Germany/FRG/1989) (Ra/LV/RHDV/GH/1989/GE) (RHDV-FRG) reference strain

Select_allDeselect_all
POLG_RHDVF Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDVF Minor capsid protein VP2

3 entries

Canine calicivirus (strain 48) (CaCV)

Select_allDeselect_all
POLG_CACV4 Genome polyprotein [Cleaved into: NS1 (Protein p18); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_CACV4 Capsid protein VP1 (CP) (Capsid protein) (Coat protein) [Cleaved into: Capsid leader protein (LC); ...
VP2_CACV4 Minor capsid protein VP2

3 entries

Feline calicivirus (strain CFI/68 FIV) (FCV)

Select_allDeselect_all
POLG_FCVC6 Genome polyprotein [Cleaved into: NS1 (Protein p5.6); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_FCVC6 Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa) [Cleaved into: Capsid leader protein (LC) ...
VP2_FCVC6 Minor capsid protein VP2

3 entries

Feline calicivirus (strain F9) (FCV)

Select_allDeselect_all
POLG_FCVF9 Genome polyprotein [Cleaved into: NS1 (Protein p5.6); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_FCVF9 Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa) [Cleaved into: Capsid leader protein (LC) ...
VP2_FCVF9 Minor capsid protein VP2

3 entries

Feline calicivirus (strain Japanese F4) (FCV)

Select_allDeselect_all
POLG_FCVF4 Genome polyprotein [Cleaved into: NS1 (Protein p5.6); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_FCVF4 Capsid protein VP1 (CP) (Coat protein) (Protein 73 kDa) [Cleaved into: Capsid leader protein (LC) ...
VP2_FCVF4 Minor capsid protein VP2

3 entries

Lordsdale virus (strain GII/Human/United Kingdom/Lordsdale/1993) (Human enteric calicivirus) (Hu/NV/LD/1993/UK)

Select_allDeselect_all
POLG_LORDV Genome polyprotein [Cleaved into: NS1-2 (NS1.2) (NS1/2) (Nterm) (Protein p37); NS1; NS2; NTPase (EC ...
CAPSD_LORDV Capsid protein VP1 (CP) (Coat protein) (VP1) [Cleaved into: Soluble capsid protein]
VP2_LORDV Minor capsid protein VP2

3 entries

Norovirus (isolate Mouse/NoV/United States/MNV1/2002/GV) (MNV-1) (Murine Norovirus 1)

Select_allDeselect_all
POLG_MNV1 Genome polyprotein [Cleaved into: NS1-2 (NS1.2) (NS1/2) (Protein p37); NS1; NS2; NTPase (EC ...
CAPSD_MNV1 Capsid protein VP1 (CP) (Coat protein)
VF1_MNV1 Virulence factor 1 (VF1)

3 entries

San Miguel sea lion virus serotype 1 (SMSV-1) (SMSV serotype 1)

Select_allDeselect_all
POLG_SMSV1 Genome polyprotein [Cleaved into: NS1 (Protein p16); NS2 (Protein p32); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_SMSV1 Capsid protein VP1 (CP) (Capsid protein) (Coat protein) [Cleaved into: Capsid leader protein (LC); ...
VP2_SMSV1 Minor capsid protein VP2

3 entries

Sapporo virus (strain Human/United Kingdom/Manchester/1993) (Hu/SV/Man/1993/UK)

Select_allDeselect_all
POLG_SVM93 Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC 3.6.1.15) (NS3) ...
VP2_SVM93 Minor capsid protein VP2
VP3_SVM93 Uncharacterized protein VP3

3 entries

Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK)

Select_allDeselect_all
POLG_SOUV3 Genome polyprotein [Cleaved into: NS1-2 (NS1.2) (NS1/2) (Protein p48); NTPase (EC 3.6.1.15) (NS3) ...
CAPSD_SOUV3 Capsid protein VP1 (CP) (Coat protein) [Cleaved into: Soluble capsid protein]
VP2_SOUV3 Minor capsid protein VP2

2 entries

Bovine enteric calicivirus NB (isolate Bovine/United States/N ebraska/1980) (BEC-NB)

Select_allDeselect_all
POLG_BECNB Genome polyprotein [Cleaved into: Protein p34; NTPase (EC 3.6.1.15) (p37); Protein p30; Viral ...
VP2_BECNB Minor capsid protein VP2

2 entries

Porcine enteric sapovirus (isolate Swine/United States/Cowden/1980) (Sw/SV/Cowden/1980/US)

Select_allDeselect_all
POLG_PESV Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC 3.6.1.15) (NS3) ...
VP2_PESV Minor capsid protein VP2

2 entries

Rabbit hemorrhagic disease virus (strain AST89) (Ra/LV/RHDV/AST89/1989/SP) (RHDV-AST89)

Select_allDeselect_all
POLG_RHDVA Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDVA Minor capsid protein VP2

2 entries

Rabbit hemorrhagic disease virus (strain V-351) (Ra/LV/RHDV/V351/1991/CK) (RHDV-V351)

Select_allDeselect_all
POLG_RHDV3 Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
VP2_RHDV3 Minor capsid protein VP2

2 entries

San Miguel sea lion virus serotype 4 (SMSV-4) (SMSV serotype 4)

Select_allDeselect_all
CAPSD_SMSV4 Capsid protein VP1 (CP) (Capsid protein) (Coat protein) [Cleaved into: Capsid leader protein (LC); ...
VP2_SMSV4 Minor capsid protein VP2

2 entries

Sapporo virus (isolate GII/Human/Thailand/Mc10/2000) (Hu/SaV/Mc10/2000/Thailand)

Select_allDeselect_all
POLG_SVM10 Genome polyprotein [Cleaved into: NS1 (Protein p11); NS2 (Protein p28); NTPase (EC 3.6.1.15) (NS3) ...
VP2_SVM10 Minor capsid protein VP2

1 entry

European brown hare syndrome virus (strain GD) (Ha/LV/EBHSV/GD/1989/FR) (EBHSV-GD)

POLG_EBHSG Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...

1 entry

Feline calicivirus (FCV)

POLG_FCV Genome polyprotein [Cleaved into: Protein p5.6 (NS1); Protein p32 (NS2); NTPase (EC 3.6.1.15) (NS3) ...

1 entry

Rabbit calicivirus (Ra/LV/RHDV/RCV/1995/IT) (RHDV)

CAPSD_RHDVR Subgenomic capsid protein VP60

1 entry

Rabbit hemorrhagic disease virus (strain BS89) (Ra/LV/RHDV/BS89/1989/IT) (RHDV-BS89)

POLG_RHDVB Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...

1 entry

Rabbit hemorrhagic disease virus (strain SD) (Ra/LV/RHDV/SD/1989/FR) (RHDV-SD)

POLG_RHDVS Genome polyprotein (p254) [Cleaved into: NS1 (Protein p16); NS2 (Protein p23); NTPase (EC 3.6.1.15) ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Atlantic salmon calicivirus taxid:1489836

Protein ModelArchive
Putative minor structural protein ma-jd-viral-39815

Bat sapovirus TLC58/HK taxid:1185359

Protein ModelArchive
VP2 ma-jd-viral-58991

Bovine calicivirus strain Kirklareli taxid:1812179

Protein ModelArchive
Minor capsid protein ma-jd-viral-64752

Bovine enteric calicivirus Newbury agent-1 (isolate Bovine/UK/Newbury1/1976) taxid:331642

Protein ModelArchive
Protein VP2 (Minor capsid VP2) ma-jd-viral-64753

Calicivirus isolate TCG taxid:243550

Protein ModelArchive
VP2 minor capsid protein ma-jd-viral-64751

Calicivirus pig/AB90/CAN taxid:520973

Protein ModelArchive
VP2 ma-jd-viral-60846

Chicken calicivirus taxid:1172196

Protein ModelArchive
VP2 ma-jd-viral-57104

Goose calicivirus taxid:1493858

Protein ModelArchive
Small basic protein ma-jd-viral-66524

Mink calicivirus taxid:154122

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52280
ORF3 protein ma-jd-viral-46038

Norovirus GIII taxid:340017

Protein ModelArchive
Capsid ma-jd-viral-54537
VP2 ma-jd-viral-36156

Rabbit calicivirus Australia 1 MIC-07 taxid:576948

Protein ModelArchive
Minor structural protein ma-jd-viral-67207

Rabbit vesivirus taxid:303317

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52281
Protein VP2 (Minor capsid protein) ma-jd-viral-31373

Sapovirus (strain GII/Human/Japan/Sakai C12/2001) taxid:290314

Protein ModelArchive
ORF2 protein ma-jd-viral-40101

Vesivirus ferret badger/JX12/China/2012 taxid:1615583

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52283
Protein VP2 (Minor capsid protein) ma-jd-viral-31374

Walrus calicivirus (isolate Walrus/Russia/7420/1977) taxid:146073

Protein ModelArchive
Capsid protein (Coat protein) ma-jd-viral-52278
Protein VP2 (Minor capsid protein) ma-jd-viral-31372