Modulation of host ubiquitin pathway by virus

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. Typically, a ubiquitin-activating enzyme (E1) binds ubiquitin in an adenosine triphosphate dependent manner. Ubiquitin is then transferred to a ubiquitin-conjugating enzyme (E2). A ubiquitin ligase (E3) helps transfer ubiquitin to the target substrate. In turn, polyubiquitination targets proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Viruses have evolved different strategies to modulate host cell ubiquitin machinery. The reasons of this manipulation are multiple including modulation of the host cell cycle, viral replication, inhibition of the host immune system or viral budding. The modification of the ub system includes the modulation of cellular E3 ligases, the synthesis of viral E3 ligases, viral deubiquitinases, or viral ubiquitin-like proteins that will perturb normal host Ub pathways.

Matching UniProtKB/Swiss-Prot entries

144 entries grouped by protein (browse by keywords)

2 entries

Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

Select_allDeselect_all
CP77_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
CP77_COWPX
Cowpox virus (CPV)

7 entries

Early E1A protein (Early E1A 27 kDa protein)

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E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
E1A_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

1 entry

Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)

E434_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

1 entry

E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)

IAP3_NPVOP
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain

7 entries

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)

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ICP0_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

ICP0_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

ICP0_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

ICP0_BHV1J
Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_BHV1K
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_EHV1V
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin transferase ICP0)

ICP0_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin transferase ICP0)

1 entry

E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)

IE2_NPVAC
Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

2 entries

E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)

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IE61_CHV9D
Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain
IE61_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ubiquitin transferase IE61)

7 entries

Kelch repeat and BTB domain-containing protein 1

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KBTB1_CAMPS
Camelpox virus (strain CMS) reference strain
KBTB1_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
KBTB1_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

Kelch repeat and BTB domain-containing protein A55

KBTB1_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)
KBTB1_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
KBTB1_HSPV
Horsepox virus (HSPV)
KBTB1_VACCC
Vaccinia virus (strain Copenhagen) (VACV)

4 entries

Kelch repeat and BTB domain-containing protein 2

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KBTB2_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain
KBTB2_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)
KBTB2_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)
KBTB2_HSPV
Horsepox virus (HSPV)

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_CCHFI
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain
L_DUGBA
Dugbe virus (isolate ArD44313) (DUGV) reference strain

6 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

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LAP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
LAP_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
LAP_YLDV
Yaba-like disease virus (YLDV) reference strain
LAP_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase)

LAP_LSDV
Lumpy skin disease virus (LSDV)
LAP_SWPVK
Swinepox virus (strain Kasza) (SWPV)

3 entries

Latent membrane protein 2 (Terminal protein)

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LMP2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

LT_SV40
Simian virus 40 (SV40) reference strain

23 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

Select_allDeselect_all
LTP_ALHV1
Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain
LTP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain
LTP_EHV2
Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain
LTP_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
LTP_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
LTP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
LTP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
LTP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
LTP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
LTP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
LTP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
LTP_MHV68
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
LTP_MUHVK
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus) reference strain
LTP_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
LTP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
LTP_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
LTP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LTP_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
LTP_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)
LTP_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

1 entry

Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)

MT5_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

7 entries

E3 ubiquitin ligase p28-like (EC 2.3.2.-) (E3 ubiquitin transferase p28-like)

Select_allDeselect_all
P28_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein CPXV023) (RING-type E3 ubiquitin transferase p28-like)

P28_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (D4R protein) (RING-type E3 ubiquitin transferase p28-like)

P28_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein C7R) (RING-type E3 ubiquitin transferase p28-like)

P28_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

E3 ubiquitin-protein ligase p28 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

P28_MONPZ
Monkeypox virus (strain Zaire-96-I-16) (MPX)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein D5R) (RING-type E3 ubiquitin transferase p28-like)

P28_VACC0
Vaccinia virus (strain LC16m0) (VACV)
P28_VACC8
Vaccinia virus (strain LC16m8) (VACV)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

1 entry

RNA replicase polyprotein (206 kDa polyprotein)

POLR_TYMV
Turnip yellow mosaic virus reference strain

26 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005) reference strain
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005) reference strain
R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63)
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
R1A_MERS1
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV)

27 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005) reference strain
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005) reference strain
R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

pdb 5R7Y; 5R7Z; 5R80; 5R81; 5R82; 5R83; 5R84; 5R8T; 5RE4; 5RE5; 5RE6; 5RE7; 5RE8; 5RE9; 5REA; 5REB; 5REC; 5RED; 5REE; 5REF; 5REG; 5REH; 5REI; 5REJ; 5REK; 5REL; 5REM; 5REN; 5REO; 5REP; 5RER; 5RES; 5RET; 5REU; 5REV; 5REW; 5REX; 5REY; 5REZ; 5RF0; 5RF1; 5RF2; 5RF3; 5RF4; 5RF5; 5RF6; 5RF7; 5RF8; 5RF9; 5RFA; 5RFB; 5RFC; 5RFD; 5RFE; 5RFF; 5RFG; 5RFH; 5RFI; 5RFJ; 5RFK; 5RFL; 5RFM; 5RFN; 5RFO; 5RFP; 5RFQ; 5RFR; 5RFS; 5RFT; 5RFU; 5RFV; 5RFW; 5RFX; 5RFY; 5RFZ; 5RG0; 5RG1; 5RG2; 5RG3; 5RGG; 5RGH; 5RGI; 5RGJ; 5RGK; 5RGL; 5RGM; 5RGN; 5RGO; 5RGP; 5RGQ; 5RGR; 5RGS; 5RGT; 5RGU; 5RGV; 5RGW; 5RGX; 5RGY; 5RGZ; 5RH0; 5RH1; 5RH2; 5RH3; 5RH4; 5RH5; 5RH6; 5RH7; 5RH8; 5RH9; 5RHA; 5RHB; 5RHC; 5RHD; 5RHE; 5RHF; 5RL0; 5RL1; 5RL2; 5RL3; 5RL4; 5RL5; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 5RS7; 5RS8; 5RS9; 5RSB; 5RSC; 5RSD; 5RSE; 5RSF; 5RSG; 5RSH; 5RSI; 5RSJ; 5RSK; 5RSL; 5RSM; 5RSN; 5RSO; 5RSP; 5RSQ; 5RSR; 5RSS; 5RST; 5RSU; 5RSV; 5RSW; 5RSX; 5RSY; 5RSZ; 5RT0; 5RT1; 5RT2; 5RT3; 5RT4; 5RT5; 5RT6; 5RT7; 5RT8; 5RT9; 5RTA; 5RTB; 5RTC; 5RTD; 5RTE; 5RTF; 5RTG; 5RTH; 5RTI; 5RTJ; 5RTK; 5RTL; 5RTM; 5RTN; 5RTO; 5RTP; 5RTQ; 5RTR; 5RTS; 5RTT; 5RTU; 5RTV; 5RTW; 5RTX; 5RTY; 5RTZ; 5RU0; 5RU1; 5RU2; 5RU3; 5RU4; 5RU5; 5RU6; 5RU7; 5RU8; 5RU9; 5RUA; 5RUC; 5RUD; 5RUE; 5RUF; 5RUG; 5RUH; 5RUI; 5RUJ; 5RUK; 5RUL; 5RUM; 5RUN; 5RUO; 5RUP; 5RUQ; 5RUR; 5RUS; 5RUT; 5RUU; 5RUV; 5RUW; 5RUX; 5RUY; 5RUZ; 5RV0; 5RV1; 5RV2; 5RV3; 5RV4; 5RV5; 5RV6; 5RV7; 5RV8; 5RV9; 5RVA; 5RVB; 5RVC; 5RVD; 5RVE; 5RVF; 5RVG; 5RVH; 5RVI; 5RVJ; 5RVK; 5RVL; 5RVM; 5RVN; 5RVO; 5RVP; 5RVQ; 5RVR; 5RVS; 5RVT; 5RVU; 5RVV; 5S18; 5S1A; 5S1C; 5S1E; 5S1G; 5S1I; 5S1K; 5S1M; 5S1O; 5S1Q; 5S1S; 5S1U; 5S1W; 5S1Y; 5S20; 5S22; 5S24; 5S26; 5S27; 5S28; 5S29; 5S2A; 5S2B; 5S2C; 5S2D; 5S2E; 5S2F; 5S2G; 5S2H; 5S2I; 5S2J; 5S2K; 5S2L; 5S2M; 5S2N; 5S2O; 5S2P; 5S2Q; 5S2R; 5S2S; 5S2T; 5S2U; 5S2V; 5S2W; 5S2X; 5S2Y; 5S2Z; 5S30; 5S31; 5S32; 5S33; 5S34; 5S35; 5S36; 5S37; 5S38; 5S39; 5S3A; 5S3B; 5S3C; 5S3D; 5S3E; 5S3F; 5S3G; 5S3H; 5S3I; 5S3J; 5S3K; 5S3L; 5S3M; 5S3N; 5S3O; 5S3P; 5S3Q; 5S3R; 5S3S; 5S3T; 5S3U; 5S3V; 5S3W; 5S3X; 5S3Y; 5S3Z; 5S40; 5S41; 5S42; 5S43; 5S44; 5S45; 5S46; 5S47; 5S48; 5S49; 5S4A; 5S4B; 5S4C; 5S4D; 5S4E; 5S4F; 5S4G; 5S4H; 5S4I; 5S4J; 5S4K; 5S6X; 5S6Y; 5S6Z; 5S70; 5S71; 5S72; 5S73; 5S74; 6LU7; 6LZE; 6M03; 6M0K; 6M2N; 6M2Q; 6M71; 6VWW; 6VXS; 6W01; 6W02; 6W4B; 6W4H; 6W61; 6W63; 6W6Y; 6W75; 6W9C; 6W9Q; 6WC1; 6WCF; 6WEN; 6WEY; 6WIQ; 6WJT; 6WKQ; 6WKS; 6WLC; 6WNP; 6WOJ; 6WQ3; 6WQD; 6WQF; 6WRH; 6WRZ; 6WTC; 6WTJ; 6WTK; 6WTM; 6WTT; 6WUU; 6WVN; 6WX4; 6WXC; 6WXD; 6WZU; 6X1B; 6X4I; 6XA4; 6XA9; 6XAA; 6XB0; 6XB1; 6XB2; 6XBG; 6XBH; 6XBI; 6XCH; 6XDH; 6XFN; 6XG3; 6XHM; 6XHU; 6XIP; 6XKF; 6XKH; 6XKM; 6XMK; 6XOA; 6XQS; 6XQT; 6XQU; 6XR3; 6Y2E; 6Y2F; 6Y2G; 6Y84; 6YB7; 6YNQ; 6YVA; 6YVF; 6YWK; 6YWL; 6YWM; 6YYT; 6YZ1; 6Z2E; 6Z5T; 6Z6I; 6Z72; 6ZCT; 6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 6ZPE; 6ZRT; 6ZRU; 6ZSL; 7A1U; 7ABU; 7ADW; 7AF0; 7AGA; 7AHA; 7AK4; 7AKU; 7ALH; 7ALI; 7AMJ; 7ANS; 7AP6; 7APH; 7AQE; 7AQI; 7AQJ; 7AR5; 7AR6; 7ARF; 7AVD; 7AWR; 7AWS; 7AWU; 7AWW; 7AX6; 7AXM; 7AXO; 7AY7; 7B3E; 7B83; 7BB2; 7BE7; 7BF3; 7BF4; 7BF5; 7BF6; 7BFB; 7BGP; 7BQ7; 7BQY; 7BRO; 7BRP; 7BTF; 7BUY; 7BV1; 7BV2; 7BZF; 7C2I; 7C2J; 7C2K; 7C2Q; 7C2Y; 7C6S; 7C6U; 7C7P; 7C8B; 7C8R; 7C8T; 7C8U; 7CBT; 7CJD; 7CJM; 7CMD; 7COM; 7CWB; 7CWC; 7CX9; 7D1M; 7D1O; 7JFQ; 7JHE; 7JIB; 7JKV; 7JME; 7JOY; 7JP1; 7JPE; 7JPY; 7JPZ; 7JQ0; 7JQ1; 7JQ2; 7JQ3; 7JQ4; 7JQ5; 7JQB; 7JQC; 7JR3; 7JR4; 7JST; 7JU7; 7JUN; 7JVZ; 7JYC; 7JYY; 7JZ0; 7K0F; 7K1L; 7K1O; 7K3N; 7K3T; 7K40; 7K5I; 7K6D; 7K6E; 7K7P; 7K9P; 7KAG; 7KEG; 7KEH; 7KF4; 7KFI; 7KG3; 7KHP; 7KOA; 7KPH; 7KQO; 7KQP; 7KQW; 7KR0; 7KR1; 7KVL; 7KVR; 7KX5; 7KXB; 7KYU; 7L0D; 7L10; 7L11; 7L12; 7L13; 7L14; 7L1F; 7L5D; 7L6R; 7L6T; 7LB7; 7LBN; 7LBR; 7LBS; 7LDX; 7LFE; 7LFP; 7LFZ; 7LG2; 7LG3; 7LG7; 7LGO; 7LKR; 7LKS; 7LKT; 7LKU; 7LKV; 7LKW; 7LKX; 7LLF; 7LLZ; 7LOS; 7LTJ; 7NBR; 7NBS; 7NBY; 7NEV; 7NFV

R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63)
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
R1AB_MERS1
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV)

6 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

Select_allDeselect_all
RPOA_EAVBU
Equine arteritis virus (strain Bucyrus) (EAV) reference strain
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

1 entry

RING finger containing E3 ubiquitin-protein ligase WSV222 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase WSV222)

UB222_WSSVS
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

1 entry

RING finger containing E3 ubiquitin-protein ligase WSV403 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase WSV403)

UB403_WSSVS
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

2 entries

Ubiquitin-like protein

Select_allDeselect_all
UBIL_NPVAC
Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

viral Ubiquitin

UBIL_NPVOP
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain

5 entries

E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)

Select_allDeselect_all
VIE2_NPVHC
Hyphantria cunea nuclear polyhedrosis virus (HcNPV) reference strain
VIE2_NPVOP
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain
VIE2_NPVR1
Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV) reference strain
VIE2_NPVBM
Bombyx mori nuclear polyhedrosis virus (BmNPV)
VIE2_NPVCF
Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV)