Modulation of host ubiquitin pathway by viral E3 ligase

Numerous cellular processes are regulated by the reversible conjugation of ubiquitin (UB) or ubiquitin-like (UBL) proteins to substrates. The E3 ubiquitin ligase operates in conjunction with an E1 ubiquitin-activating enzyme and an E2 ubiquitin-conjugating enzyme and transfers ubiquitin to the target substrate. Two types of E3 ubiquitin ligases are present in cells based on the structure of their catalytic domain named RING and HECT. The E3s polyubiquitinate target proteins to a cellular organelle known as the 26S proteasome where substrates are degraded into small peptides. Proteasomal degradation is critical component of many cellular processes including cell cycle regulation,induction of the inflammatory response and antigen presentation.

Several viruses encode viral E3 ligases in order to direct specific substrates for proteasomal degradation. For example, herpes simplex virus encodes ICPO which acts as a nuclear E3 ubiquitin ligase that polyubiquitinates the nuclear bodies-associated PML and Sp100 proteins.

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by protein (browse by keywords)

1 entry

Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)

E434_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

1 entry

E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)

IAP3_NPVOP
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain

7 entries

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)

Select_allDeselect_all
ICP0_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

ICP0_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

ICP0_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

ICP0_BHV1J
Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_BHV1K
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_EHV1V
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin transferase ICP0)

ICP0_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin transferase ICP0)

1 entry

E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)

IE2_NPVAC
Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

2 entries

E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61)

Select_allDeselect_all
IE61_CHV9D
Cercopithecine herpesvirus 9 (strain DHV) (CeHV-9) (Simian varicella virus) reference strain
IE61_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ubiquitin transferase IE61)

6 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

Select_allDeselect_all
LAP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
LAP_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
LAP_YLDV
Yaba-like disease virus (YLDV) reference strain
LAP_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase)

LAP_LSDV
Lumpy skin disease virus (LSDV)
LAP_SWPVK
Swinepox virus (strain Kasza) (SWPV)

7 entries

E3 ubiquitin ligase p28-like (EC 2.3.2.-) (E3 ubiquitin transferase p28-like)

Select_allDeselect_all
P28_CWPXB
Cowpox virus (strain Brighton Red) (CPV) reference strain

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein CPXV023) (RING-type E3 ubiquitin transferase p28-like)

P28_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (D4R protein) (RING-type E3 ubiquitin transferase p28-like)

P28_CWPXG
Cowpox virus (strain GRI-90 / Grishak) (CPV)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein C7R) (RING-type E3 ubiquitin transferase p28-like)

P28_ECTVM
Ectromelia virus (strain Moscow) (ECTV) (Mousepox virus)

E3 ubiquitin-protein ligase p28 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

P28_MONPZ
Monkeypox virus (strain Zaire-96-I-16) (MPX)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (Protein D5R) (RING-type E3 ubiquitin transferase p28-like)

P28_VACC0
Vaccinia virus (strain LC16m0) (VACV)
P28_VACC8
Vaccinia virus (strain LC16m8) (VACV)

E3 ubiquitin-protein ligase p28-like (EC 2.3.2.27) (RING-type E3 ubiquitin transferase p28-like)

1 entry

RING finger containing E3 ubiquitin-protein ligase WSV222 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase WSV222)

UB222_WSSVS
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

1 entry

RING finger containing E3 ubiquitin-protein ligase WSV403 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase WSV403)

UB403_WSSVS
White spot syndrome virus (isolate Shrimp/China/Tongan/1996) (WSSV) (White spot bacilliform virus) reference strain

5 entries

E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)

Select_allDeselect_all
VIE2_NPVCF
Choristoneura fumiferana nuclear polyhedrosis virus (CfMNPV) reference strain
VIE2_NPVOP
Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) reference strain
VIE2_NPVR1
Rachiplusia ou multiple nucleopolyhedrovirus (strain R1) (RoMNPV) reference strain
VIE2_NPVBM
Bombyx mori nuclear polyhedrosis virus (BmNPV)
VIE2_NPVHC
Hyphantria cunea nuclear polyhedrosis virus (HcNPV)