Viral attachment to host entry receptor

Entry receptors trigger virus entry by endocytosis/pinocytosis or by inducing fusion/penetration. The consequences of this binding are irreversible. They have often be named “co-receptors”. Entry receptors are often difficult to access for the virion, which circumvents this problem by binding first to adhesion receptors, which increases the probability of binding to the entry receptor.



In herpesviruses for example, gC makes the primary contact with the host cell surface, binding to heparan sulfate proteoglycans. Binding of gD to the entry receptors induces viral fusion to the host cell membrane and viral penetration .
In bacterial viruses, attachment to the entry receptor is often referred to as irreversible adsorption, based on experimental observations .

Matching UniProtKB/Swiss-Prot entries

81 entries grouped by protein (browse by keywords)

All proteins are shown (view only 47 complete proteome entries)

9 entries

Secreted protein ORF2 (Protein ORF2) (pORF2)

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CAPSD_HEVCH
Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain
CAPSD_HEVBU
Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)
CAPSD_HEVHY
Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)
CAPSD_HEVMY
Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)
CAPSD_HEVPA
Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)
CAPSD_PAVC
Canine parvovirus type 2 (CPV-2)

Capsid protein VP2 (Coat protein VP2)

CAPSD_PAVCB
Canine parvovirus type 2 (isolate Dog/United States/CPV-b/1978) (CPV-2)

Capsid protein VP1 (Coat protein VP1)

CAPSD_PAVCD
Canine parvovirustype 2 (isolate Dog/United States/CPV-d/1988) (CPV-2)

Capsid protein VP1 (Coat protein VP1)

CAPSD_PAVCN
Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)

Capsid protein VP1 (Coat protein VP1)

1 entry

Envelope glycoprotein (Env polyprotein)

ENV_JSRV
Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)

1 entry

Short tail fiber protein gp12 (Gene product 12) (gp12)

FIB12_BPT4
Enterobacteria phage T4 (Bacteriophage T4) reference strain

1 entry

Tail spike protein (TSP) (Gene product 21) (Gp21)

FIBER_BPSPP
Bacillus phage SPP1 (Bacteriophage SPP1) reference strain

9 entries

Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)

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G3P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G3P_BPIF1
Enterobacteria phage If1 (Bacteriophage If1) reference strain
G3P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain
G3P_BPM13
Enterobacteria phage M13 (Bacteriophage M13) reference strain
G3P_BPPF1
Pseudomonas phage Pf1 (Bacteriophage Pf1) reference strain
G3P_BPPF3
Pseudomonas phage Pf3 (Bacteriophage Pf3) reference strain
G3P_BPPHL
Xanthomonas phage phiLf (Bacteriophage phi-Lf) reference strain
G3P_BPF1
Enterobacteria phage f1 (Bacteriophage f1)
G3P_BPFD
Enterobacteria phage fd (Bacteriophage fd)

19 entries

Envelope glycoprotein D (gD)

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GD_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain
GD_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GD_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GD_PSHV1
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain
GD_BHV1C
Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Envelope glycoprotein D (gD) (Glycoprotein IV)

GD_BHV1P
Bovine herpesvirus 1.1 (strain P8-2) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Envelope glycoprotein D (gD) (Glycoprotein IV)

GD_BHV1S
Bovine herpesvirus 1.2 (strain ST) (BoHV-1) (Infectious bovine rhinotracheitis virus)

Envelope glycoprotein D (gD) (Glycoprotein IV)

GD_CHV1
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)
GD_EHV1A
Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus)

Envelope glycoprotein D (gD) (Glycoprotein 17/18)

GD_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)

Envelope glycoprotein D (gD) (Glycoprotein 17/18)

GD_EHV1D
Equine herpesvirus 1 (strain Kentucky D) (EHV-1) (Equine abortion virus)

Envelope glycoprotein D (gD) (Glycoprotein 17/18)

GD_EHV1K
Equine herpesvirus 1 (strain Kentucky A) (EHV-1) (Equine abortion virus)

Envelope glycoprotein D (gD) (Glycoprotein 17/18)

GD_HHV1A
Human herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1H
Human herpesvirus 1 (strain HZT) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1P
Human herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1)
GD_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GD_SUHVR
Suid herpesvirus 1 (strain Rice) (SuHV-1) (Pseudorabies virus (strain Rice))

Envelope glycoprotein D (gD) (Protein gp50)

2 entries

Envelope glycoprotein E (gE)

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GE_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain
GE_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

3 entries

Envelope glycoprotein H (gH)

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GH_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GH_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GH_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

12 entries

Envelope glycoprotein L (gL)

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GL_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
GL_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
GL_GPCMV
Guinea pig cytomegalovirus (strain 22122) (GPCMV)
GL_HCMV1
Human cytomegalovirus (strain 119) (HHV-5) (Human herpesvirus 5)
GL_HCMV2
Human cytomegalovirus (strain 1042) (HHV-5) (Human herpesvirus 5)
GL_HCMV3
Human cytomegalovirus (strain 2387) (HHV-5) (Human herpesvirus 5)
GL_HCMV4
Human cytomegalovirus (strain 4654) (HHV-5) (Human herpesvirus 5)
GL_HCMV5
Human cytomegalovirus (strain 5035) (HHV-5) (Human herpesvirus 5)
GL_HCMV6
Human cytomegalovirus (strain 5040) (HHV-5) (Human herpesvirus 5)
GL_HCMV7
Human cytomegalovirus (strain 5160) (HHV-5) (Human herpesvirus 5)
GL_HCMV8
Human cytomegalovirus (strain 5508) (HHV-5) (Human herpesvirus 5)
GL_HCMVP
Human cytomegalovirus (strain PT) (HHV-5) (Human herpesvirus 5)

2 entries

Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)

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GQ1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GQ1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Glycoprotein Q2 (gQ2) (Glycoprotein Q-37k) (gQ-37k)

GQ2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

2 entries

Receptor binding protein (RBP) (Gene product 18) (Gp18)

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RBP_BPLSK
Lactococcus phage SK1 (Lactococcus lactis bacteriophage SK1) reference strain
RBP_BPLP2
Lactococcus phage p2 (Lactococcus lactis bacteriophage p2)

1 entry

Receptor-binding protein (RBP) (Tail protein pb5)

RBP5_BPT5
Escherichia phage T5 (Enterobacteria phage T5) reference strain

1 entry

Spike protein (Baseplate assembly protein gpV) (Gene V protein) (GpV)

SPIKE_BPP2
Escherichia phage P2 (Bacteriophage P2) reference strain

1 entry

Tip attachment protein J (Central tail fiber) (Host specificity protein J)

TIPJ_LAMBD
Escherichia phage lambda (Bacteriophage lambda) reference strain

1 entry

Protein UL131A

U131A_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

2 entries

Envelope protein UL128

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UL128_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL128

UL128_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)

2 entries

Envelope glycoprotein UL130

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UL130_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Uncharacterized protein UL130

UL130_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

11 entries

Envelope glycoprotein (GP1,2) (GP)

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VGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VGP_EBOEC
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
VGP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VGP_EBORS
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
VGP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
VGP_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
VGP_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
VGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VGP_TAFVC
Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)