Viral receptor tropism switching

Some bacteriophages have developed tropism-switching genetic cassettes, that allow them to modify their fibers proteins, and thus to bind to a broader range of hosts.

Different mechanisms can be used:

  1. The host range variation system found in phages such as Mu and P1 is a genetic system that allows some bacterial viruses to switch between two types of fibers by inversion of the DNA segment encoding the fibers. The change in fibers specificity is performed through site specific inversion of a genome segment catalyzed by a virally encoded invertase. This genome segment codes for two alternate sets of tail fibers, of which only the "well oriented" one is expressed .
  2. Bordetella bacteriophages generate diversity in a gene that specifies host tropism produced through a genetic element that combines the basic retroelement life cycle of transcription, reverse transcription and integration with site-directed, adenine-specific mutagenesis .

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Matching UniProtKB/Swiss-Prot entries

10 entries grouped by protein (browse by keywords)

2 entries

DNA-invertase (Site-specific recombinase)

Select_allDeselect_all
CIN_BPP1
Escherichia phage P1 (Bacteriophage P1) reference strain
CIN_BPP7
Enterobacteria phage P7 (Bacteriophage P7)

1 entry

Tail fiber receptor-binding protein (Major tropism determinant protein)

FIBD_BPBPP
Bordetella phage BPP-1 reference strain

1 entry

Serine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin) (Gene product 53) (gp53)

GIN_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail fiber protein S (Gene product 49) (gp49) (Gene product S) (gpS)

S1_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

1 entry

Tail fiber protein S' (Gene product S') (gpS')

S2_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain

2 entries

Tail fiber assembly protein U (Gene product 50) (gp50) (Gene product U) (gpU)

Select_allDeselect_all
U1_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
U1_BPP1
Escherichia phage P1 (Bacteriophage P1) reference strain

Tail fiber assembly protein U (Gene product U) (gpU)

2 entries

Tail fiber assembly protein U' (Gene product U') (gpU')

Select_allDeselect_all
U2_BPMU
Escherichia phage Mu (Bacteriophage Mu) reference strain
U2_BPP1
Escherichia phage P1 (Bacteriophage P1) reference strain