Quaranjavirus

VIRION

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Enveloped, spherical. The virions are 80-120 nm in diameter

GENOME

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segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 segments coding for 6 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

6 entries grouped by protein (browse by keywords)

1 entry

Envelope glycoprotein

ENV_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain

1 entry

Probable matrix protein

M1_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain

1 entry

Nucleoprotein (Nucleocapsid protein) (Protein N)

NCAP_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain

1 entry

Polymerase acidic protein (PA)

PA_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain

1 entry

Polymerase basic protein 2 (PB2)

PB2_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain

1 entry

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48)

RDRP_QRFVE
Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) reference strain