Muvirus (taxid:186777)
VIRION
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Non-enveloped, head-tail structure. The icosahedral head is about 54 nm with a knob-like neck. The tails is contractile, has a baseplate and 6 short fibers.
GENOME
Linear, dsDNA genome of about 40 kb, encoding for 56 proteins. 50-150 bp and about 2 Kb of bacterial DNA are respectively covalently linked at the left and the right end of Mu genome. The presence of these pieces of bacterial DNA is due to the headful packaging mechanism.
GENE EXPRESSION
Genes are transcribed by operons.
REPLICATION
CYTOPLASMIC
- Adsorption: the phage attaches to the target cell lipopolysaccharides (LPS) through its tail fibers. Two types of fibers are encoded by the phage to allow receptor tropism switching.
- Ejection of the viral DNA into host cell cytoplasm by contraction of the tail sheath.
- Viral DNA ends are protected from degradation by host nucleases.
- ?Transcription and translation of early genes?
- Circularization and supercoiling of the viral DNA.
- Integration of viral DNA into the host chromosome.
- Replicative transposition gives rise to 50-100 new copies of the viral genome in the host chromosome.
- Transcription and translation of late genes.
- Assembly of an empty procapsid.
- Momylation of viral DNA (modification of adenines) makes the packaged viral DNA resistant to host restriction enzymes.
- Viral tail fibers assembly and viral tail assembly.
- Mature virions are released from the cell by lysis.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)65 entries grouped by protein
1 entry
Late transcription activator C (C) (Gene product 21) (gp21) (Protein C)
1 entry
Baseplate hub protein gp44 (43 kDa tail protein) (Gene product 44) (gp44) (Gene product P) (gpP)
1 entry
Baseplate puncturing device gp45 (Baseplate spike protein) (Gene product 45) (gp45) (Gene product Q) (gpQ)
1 entry
Baseplate protein gp46 (Gene product 46) (gp46) (Gene product V) (gpV)
1 entry
Baseplate protein gp47 (Gene product 47) (gp47) (Gene product W) (gpW)
1 entry
Baseplate protein gp48 (Gene product 48) (gp48) (Gene product R) (gpR)
1 entry
Major capsid protein (Gene product 34) (gp34) (Gene product T) (gpT) (Major head protein)
1 entry
DNA circularization protein N (64 kDa virion protein) (Gene product 43) (gp43) (Gene product N) (gpN)
2 entries
Translational activator com (Gene product 54) (gp54) (Gene product com) (gpCom)
1 entry
Uncharacterized protein gp14 (E15) (Gene product 14) (gp14)
1 entry
SAR-endolysin (EC 3.2.1.17) (Endolysin) (Gene product 22) (gp22) (Lysis protein) (Lysozyme) (Muramidase)
1 entry
Putative DNA ends protecting protein gam (Gene product 10) (gp10)
2 entries
GemA protein (Gene product 16) (gp16)
1 entry
D108-specific protein (12 kDa protein)
2 entries
Serine recombinase gin (EC 3.1.22.-) (EC 6.5.1.-) (G-segment invertase) (Gin)
1 entry
Uncharacterized protein gp11 (Gene product 11) (gp11)
1 entry
Uncharacterized protein gp12 (E13) (Gene product 12) (gp12)
1 entry
Uncharacterized protein gp13 (E14) (Gene product 13) (gp13)
1 entry
Uncharacterized protein gp14 (E15) (Gene product 14) (gp14)
1 entry
Uncharacterized protein gp15 (Gene product 15) (gp15)
1 entry
Uncharacterized protein gp18 (E18) (E18 protein) (Gene product 18)
1 entry
Uncharacterized protein gp19 (E19 protein) (Gene product 19) (gp19)
1 entry
Uncharacterized protein gp24 (Gene product 24) (gp24)
1 entry
Uncharacterized protein gp26 (Gene product 26) (gp26)
1 entry
Uncharacterized protein gp35 (Gene product 35) (gp35)
1 entry
Putative sheath terminator protein (Gene product 38) (gp38)
1 entry
Uncharacterized protein gp6 (E5) (Gene product 6) (gp6)
1 entry
Uncharacterized protein gp7 (E6) (Gene product 7) (gp7)
1 entry
Uncharacterized protein gp8 (E7) (Gene product 8) (gp8)
1 entry
Uncharacterized protein gp9 (E8) (Gene product 9) (gp9)
1 entry
Putative capsid assembly protein F (Gene product 30) (gp30) (Gene product F) (gpF)
1 entry
Putative capsid assembly protein G (Gene product G) (gpG)
1 entry
Gene product J (gpJ) (Gene product 36) (gp36)
1 entry
Protein kil (Gene product 5) (gp5) (Protein cim)
2 entries
Methylcarbamoylase mom (Adenine modification enzyme mom) (Gene product 55) (gp55) (Gene product mom) (gpMom) (Modification of Mu) (Mom)
1 entry
Middle operon regulator (Mor) (GemB) (Gene product 17) (gp17)
2 entries
Negative regulator of transcription (Ner)
1 entry
Portal protein (Gene product 29) (gp29) (Gene product H) (gpH) (Head-tail connector)
1 entry
Protease I (Gene product 32) (gp32) (Gene product I) (gpI)
2 entries
Repressor c protein (Repc) (CI)
1 entry
Releasin protein (Gene product 25) (gp25)
1 entry
Tail fiber protein S (Gene product 49) (gp49) (Gene product S) (gpS)
1 entry
Tail fiber protein S' (Gene product S') (gpS')
1 entry
Spanin, inner membrane subunit (i-spanin) (gene product 23) (gp23)
1 entry
Spanin, outer lipoprotein subunit (o-spanin) (gene product 23.1) (gp23.1)
1 entry
Probable tail assembly protein gp41 (Gene product 41) (gp41) (Tail assembly chaperone)
1 entry
Probable tail assembly protein FS-gp41
2 entries
ATP-dependent target DNA activator B (EC 3.6.1.-) (Gene product 04) (gp04) (Gene product B) (gpB) (MuB)
1 entry
Probable terminase, large subunit gp28 (EC 3.1.-.-) (Gene product 28) (gp28) (Gene product E) (gpE) (Pacase, large subunit) (Packaging protein E)
1 entry
Probable terminase, small subunit gp27 (Gene product 27) (gp27) (Gene product D) (gpD) (Pacase, small subunit) (Packaging protein D)
1 entry
Probable tape measure protein (TMP) (Gene product 42) (gp42) (Gene product Y) (gpY)
1 entry
DDE-recombinase A (EC 3.1.22.-) (EC 6.5.1.-) (DDE-transposase A) (Gene product 03) (gp03) (Gene product A) (gpA) (MuA)
1 entry
Probable tail terminator protein (TrP) (Gene product 37) (gp37) (Gene product K) (gpK)
1 entry
Tail sheath protein (TSP) (Gene product 39) (gp39) (Gene product L) (gpL)
1 entry
Tail tube protein (TTP) (Gene product 40) (gp40) (Gene product M) (gpM)
1 entry
Tail fiber assembly protein U (Gene product 50) (gp50) (Gene product U) (gpU)
1 entry
Tail fiber assembly protein U' (Gene product U') (gpU')
1 entry