Macavirus (taxid:548687)
VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.
GENOME
Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.
GENE EXPRESSION
Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.
ENZYMES
- DNA-dependent DNA polymerase
- DNA primase
- Tegument deneddylase (Peptidase C76)
- Assemblin (Peptidase S21)
- Kinase
- Helicase
- Ribonucleoside-diphosphate reductase
- Thymidine kinase
- Uracil-DNA glycosylase
REPLICATION
NUCLEAR
Lytic replication:
- Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
- The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
- Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
- Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
- A first round of circular genome amplification occurs by bidirectional replication
- Synthesis of linear concatemer copies of viral DNA by rolling circle.
- Transcription of late mRNAs by host polymerase II, encoding structural proteins.
- Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.
Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.
Host-virus interaction
Apoptosis modulation
Alcelaphine herpesvirus 1 encodes a bcl-2 homologue that may inhibit host apoptosis.
Host splicing inhibition
Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)71 entries grouped by protein
1 entry
Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
1 entry
Putative transcription activator BRLF1 homolog
1 entry
Cytoplasmic envelopment protein 1
1 entry
Cytoplasmic envelopment protein 2
1 entry
Cytoplasmic envelopment protein 3
1 entry
Capsid vertex component 1
1 entry
Capsid vertex component 2
1 entry
Major DNA-binding protein
1 entry
DNA polymerase catalytic subunit (EC 2.7.7.7)
1 entry
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
1 entry
Envelope glycoprotein B (gB)
1 entry
Envelope glycoprotein H (gH)
1 entry
Envelope glycoprotein L (gL)
1 entry
Envelope glycoprotein M (gM)
1 entry
Envelope glycoprotein N
1 entry
DNA replication helicase (EC 3.6.4.-)
1 entry
Immediate-early phosphoprotein 57
1 entry
Inner tegument protein
2 entries
Thymidine kinase (EC 2.7.1.21)
1 entry
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
1 entry
Major capsid protein (MCP)
1 entry
Nuclear egress protein 1
1 entry
Nuclear egress protein 2
1 entry
Portal protein
1 entry
DNA primase (EC 2.7.7.-)
1 entry
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)
1 entry
Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)
1 entry
Capsid scaffolding protein (Capsid protein 17) (Protease precursor) (pPR)
1 entry
Small capsomere-interacting protein
1 entry
Semaphorin-like protein A3
1 entry
Tegument protein UL51 homolog (Uncharacterized gene 55 protein)
1 entry
Tripartite terminase subunit 1
1 entry
Tripartite terminase subunit 2
1 entry
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
1 entry
Triplex capsid protein 1
1 entry
Triplex capsid protein 2
1 entry
Protein UL24 homolog
1 entry
Packaging protein UL32 homolog
1 entry
Uncharacterized gene 66 protein
1 entry
Gene 18 protein
1 entry
Uncharacterized gene 24 protein
1 entry
Uncharacterized gene 30 protein
1 entry
Gene 31 protein
1 entry
Gene 34 protein
1 entry
Gene 35 protein
1 entry
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
1 entry
Uncharacterized gene 10 protein
1 entry
Uncharacterized gene 11 protein
1 entry
Uncharacterized gene 23 protein
1 entry
Uncharacterized gene 27 protein
1 entry
Putative tyrosine kinase 36 (EC 2.7.10.2)
1 entry
Uncharacterized gene 40 protein
1 entry
Uncharacterized gene 41 protein
1 entry
Uncharacterized gene 45 protein
1 entry
Uncharacterized gene 48 protein
1 entry
Uncharacterized gene 52 protein
1 entry
Gene 58 protein
1 entry
DNA polymerase processivity factor
1 entry
Uncharacterized gene 73 protein
1 entry
Uncharacterized gene A1 protein
1 entry
Uncharacterized gene A10 protein
1 entry
Uncharacterized protein A2
1 entry
Uncharacterized gene A4 protein
1 entry
G-protein coupled receptor A5
1 entry
Uncharacterized gene A6 protein
1 entry
Putative C-type lectin protein A7
1 entry
Uncharacterized gene A8 protein
1 entry
Putative apoptosis regulator A9
1 entry
Probable tegument protein antigen 3
1 entry
Probable membrane antigen 75 (Tegument protein)
Alcelaphine gammaherpesvirus 1 taxid:35252
Protein | ModelArchive |
A2 | ma-jd-viral-12263 |
AHV-sema | ma-jd-viral-54620 |