Percavirus (taxid:548688)
VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.
GENOME
Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.
GENE EXPRESSION
Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.
ENZYMES
- DNA-dependent DNA polymerase
- DNA primase
- Tegument deneddylase (Peptidase C76)
- Assemblin (Peptidase S21)
- Kinase
- Helicase
- Ribonucleoside-diphosphate reductase
- Thymidine kinase
- Uracil-DNA glycosylase
REPLICATION
NUCLEAR
Lytic replication:
- Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
- The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
- Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
- Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
- A first round of circular genome amplification occurs by bidirectional replication
- Synthesis of linear concatemer copies of viral DNA by rolling circle.
- Transcription of late mRNAs by host polymerase II, encoding structural proteins.
- Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.
Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.
Host-virus interaction
Adaptive immune response inhibition
The viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Apoptosis modulation
The EHV-2 v-FLIP protein (ORF E8) inhibits TNFRSF1A, TNFRSF6, TNFRSF10 and TNFRSF12 induced apoptosis.
Cell-cycle modulation
The UL24 protein induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .
Splicing inhibition
Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)75 entries grouped by protein
1 entry
Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
1 entry
Putative transcription activator BRLF1 homolog
1 entry
Cytoplasmic envelopment protein 1
1 entry
Cytoplasmic envelopment protein 2
1 entry
Cytoplasmic envelopment protein 3
1 entry
Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
1 entry
Capsid vertex component 1
1 entry
Capsid vertex component 2
1 entry
Major DNA-binding protein
1 entry
DNA polymerase catalytic subunit (EC 2.7.7.7)
1 entry
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
1 entry
Envelope glycoprotein B (gB)
1 entry
Envelope glycoprotein H (gH)
1 entry
Envelope glycoprotein L (gL)
1 entry
Envelope glycoprotein M (gM)
1 entry
Envelope glycoprotein N
1 entry
DNA replication helicase (EC 3.6.4.-)
1 entry
DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
1 entry
Immediate-early phosphoprotein 57
2 entries
Viral interleukin-10 homolog (vIL-10)
1 entry
Inner tegument protein
1 entry
Thymidine kinase (EC 2.7.1.21)
1 entry
Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)
1 entry
Major capsid protein (MCP)
1 entry
Nuclear egress protein 1
1 entry
Nuclear egress protein 2
1 entry
Portal protein
1 entry
DNA primase (EC 2.7.7.-)
1 entry
Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)
1 entry
Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)
1 entry
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)
1 entry
Small capsomere-interacting protein
1 entry
Tegument protein UL51 homolog
1 entry
Tripartite terminase subunit 1
1 entry
Tripartite terminase subunit 2
1 entry
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
1 entry
Triplex capsid protein 1
1 entry
Triplex capsid protein 2
1 entry
Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)
1 entry
Protein UL24 homolog
1 entry
Packaging protein UL32 homolog
1 entry
Uncharacterized gene 66 protein
1 entry
Gene 18 protein
1 entry
Gene 24 protein
1 entry
Uncharacterized gene 30 protein
1 entry
Gene 31 protein
1 entry
Gene 34 protein
1 entry
Gene 35 protein
1 entry
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)
1 entry
CARD domain-containing protein E10
1 entry
Uncharacterized gene 10 protein
1 entry
Uncharacterized gene 11 protein
1 entry
Protein E6A
1 entry
Protein E6C
1 entry
Uncharacterized gene 23 protein
1 entry
Uncharacterized gene 27 protein
1 entry
Uncharacterized gene 28 protein
1 entry
Probable inactive protein kinase 38
1 entry
Uncharacterized gene 45 protein
1 entry
Tegument protein G48
1 entry
Uncharacterized gene 49 protein
1 entry
Putative C-type lectin protein 51
1 entry
Gene 52 protein
1 entry
Gene 58 protein
1 entry
DNA polymerase processivity factor
1 entry
G-protein coupled receptor 74
1 entry
Probable membrane antigen 75 (Tegument protein)
1 entry
G-protein coupled receptor E1
1 entry
Uncharacterized gene E2 protein
1 entry
SUSHI domain-containing protein E3
1 entry
Uncharacterized gene E4 protein
1 entry
G-protein coupled receptor E6
1 entry
Uncharacterized gene E9 protein
1 entry
Probable membrane antigen 3 (Tegument protein)
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Protein | ModelArchive |
Viral interleukin-10 homolog (vIL-10) | ma-jd-viral-13428 |