Alphabaculovirus (taxid:558016)
VIRION
Enveloped. extracellular baculovirus virions can be found in two forms: OV (occluded virus) and BV (budded virus). The nucleocapsid is about 21 nm x 260 nm.
GENOME
Circular dsDNA, 80-180 kb in length, encoding for 100 to 180 proteins.
GENE EXPRESSION
The GP64 protein is expressed by leaky scanning after a uORF.
ENZYMES
- DNA primase [LEF-1]
- DNA dependent DNA polymerase [POL]
- DNA dependent RNA polymerase [DdRp]
- Alkaline nuclease [AN]
- Cell-type capping
- Peptidase C1A [VCATH]
- Metallopreotease (Peptidase M60) [VEF]
- Serine/threonine-protein kinase [PK1]
- Tyrosine-protein phosphatase [PTP]
- Chitinase [P41684]
REPLICATION
NUCLEUS
- Attachement of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane.
- The DNA genome is released into the host nucleus.
- Immediate early phase: host RNA polymerase transcribes viral genes involved in the regulation of the replication cascade, prevention of host responses and viral DNA synthesis.
- Late phase: The virally encoded RNA polymerase expresses late genes.
- Replication of the genome by rolling circle in nuclear viral factories.
- Nucleocapsids are formed which can either bud out through the cellular membrane and disseminate the infection or be occluded for horizontal transmission.
- Occlusion phase: the virus becomes occluded in the protein polyhedrin and the polyhedral envelope (calyx) is produced. Lysis of the cell releases the occluded virus.
Host-virus interaction
Apoptosis modulation
Several viral proteins are dedicated to inhibit host apoptosis. Among them, IAP3 is a RING-finger E3 ubiquitin ligase that ubiquitinates and subsquently targets host pro-apoptotic factors. Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation.
Cell-cycle modulation
Some baculoviruses encode viral cyclins such as ODV-EC27 or BmNPV ORF120 that maintains the host cells at the G2/M phase while permitting the virus DNA replication 
.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)377 entries grouped by protein
1 entry
Uncharacterized 38.0 kDa protein in P143-LEF5 intergenic region (ORF2)
1 entry
Protein Ac102 (P12)
1 entry
Protein AC109
1 entry
Protein AC11
1 entry
Per os infectivity factor AC110
1 entry
Protein ORF114
1 entry
Transactivator protein ORF121
1 entry
Protein AC124
1 entry
Protein Ac132
1 entry
Protein AC142
1 entry
Protein AC145
1 entry
Protein AC150
1 entry
Protein AC152
1 entry
Protein AC18
1 entry
Protein AC23 (ORF 9)
1 entry
Protein Ac34
1 entry
Protein AC41
1 entry
Protein AC43
1 entry
Protein AC53
1 entry
Protein AC54
1 entry
Protein Ac66
1 entry
Protein Ac75
1 entry
Protein Ac76
1 entry
Protein AC78
1 entry
Protein AC81
1 entry
Capsid-associated protein AC83
1 entry
Protein ADP-ribose pyrophosphatase ORF38 (ORF7) (EC 3.6.1.13)
2 entries
Alkaline nuclease (AN) (EC 3.1.-.-)
1 entry
Uncharacterized Bro-N domain-containing protein J (Ld-bro-j)
2 entries
DNA-binding protein (Arginine-rich protein 6.2 kDa) (Basic viral core protein) (Nucleocapsid protein)
2 entries
Protein C42 (C42) (ORF3) (P40)
16 entries
Viral cathepsin (V-cath) (EC 3.4.22.50) (Cysteine proteinase) (CP)
2 entries
Zinc finger protein CG30
2 entries
Chitinase (EC 3.2.1.14)
1 entry
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57)
1 entry
Conotoxin-like peptide
1 entry
Conotoxin-like peptide 1
1 entry
Conotoxin-like peptide 2
1 entry
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase
5 entries
DNA polymerase (EC 2.7.7.7)
1 entry
Protein E18 (E18)
1 entry
Virus envelope protein E25 (Protein E25) (Virus envelope protein AC94)
1 entry
Protein E26 (Protein AC16)
1 entry
Occlusion-derived virus envelope protein E27 (ODV-E27)
1 entry
Ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-)
1 entry
Envelope fusion protein
2 entries
ECORI-T site protein ETM
1 entry
Uncharacterized protein ETS (ECORI-T site protein)
2 entries
Fibroblast growth factor homolog
1 entry
FAD-linked sulfhydryl oxidase (p33) (EC 1.8.3.2)
3 entries
FP protein
1 entry
Protein FP25 (25 kDa protein)
3 entries
Major envelope glycoprotein (gp64)
1 entry
Glycoprotein GP16
1 entry
Structural glycoprotein gp41
2 entries
Probable global transactivator (EC 3.6.4.-) (ATP-dependent helicase GTA)
1 entry
Protein Early 65 kDa
1 entry
DNA replication helicase (EC 3.6.4.12) (P143)
2 entries
Host range factor 1
2 entries
Apoptosis inhibitor 1 (IAP-1)
2 entries
Probable apoptosis inhibitor 2 (IAP-2)
1 entry
E3 ubiquitin-protein ligase IAP-3 (EC 2.3.2.27) (IAP-3) (RING-type E3 ubiquitin transferase IAP-3)
1 entry
Putative apoptosis inhibitor 4 (IAP-4)
3 entries
Immediate-early protein IE-0 (Immediate early 0 protein) (Immediate early transactivator 0)
1 entry
Trans-activating transcriptional regulatory protein (Immediate early protein 1) (IE-1)
1 entry
E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)
1 entry
Late expression factor 1
2 entries
Late expression factor 10
10 entries
Late expression factor 11
4 entries
Late expression factor 2
2 entries
Late expression factor 3
2 entries
mRNA capping enzyme LEF-4 (EC 2.7.7.50) (EC 3.6.1.74) (Late expression factor 4) (LEF-4)
2 entries
Late expression factor 5
2 entries
Late expression factor 7
1 entry
Probable DNA-directed RNA polymerase catalytic subunit (EC 2.7.7.6) (Late expression factor 8)
2 entries
DNA-directed RNA polymerase subunit LEF-9
1 entry
Major capsid protein
2 entries
Early 53 kDa protein (ME-53)
1 entry
Occlusion-derived virus envelope protein E18 (ODV-E18)
1 entry
Occlusion-derived virus envelope protein E27 (ODV-E27)
3 entries
Occlusion-derived virus envelope protein E56 (ODV-E56) (ODVP-6E)
3 entries
Occlusion-derived virus envelope protein E66 (ODV-E66)
1 entry
OPEP-2 protein (P25)
1 entry
OPEP-3 protein (P32)
1 entry
Protein ORF45
1 entry
Protein p10 (Fibrous body protein)
1 entry
Capsid protein p24
1 entry
Early 35 kDa protein (Apoptosis-preventing protein) (p35)
1 entry
p48 protein (p45 protein)
1 entry
DNA-binding protein (Arginine-rich protein 6.9 kDa) (Basic viral core protein) (Nucleocapsid protein)
1 entry
Protein P78/83
2 entries
Probable DNA polymerase sliding clamp (EcoRI-T site protein ETL) (Proliferating cell nuclear antigen homolog) (PCNA)
2 entries
Major immediate early protein (PE-38)
1 entry
Per os infectivity factor 0 (PIF0)
1 entry
Per os infectivity factor 1 (PIF1)
1 entry
Per os infectivity factor 2 (PIF2) (ORF 8/6)
1 entry
Per os infectivity factor 3 (PIF3)
1 entry
Per os infectivity factor 4 (PIF4)
1 entry
Per os infectivity factor 5 (PIF5) (E56)
1 entry
Per os infectivity factor 6 (PIF6)
1 entry
Protein kinase-interacting protein PIKP1 (PIKP1)
4 entries
Serine/threonine-protein kinase 1 (EC 2.7.11.1)
1 entry
Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)
3 entries
Poxin (EC 3.1.-.-) (Protein p26) (p26)
1 entry
Protein pp31 (PP31)
1 entry
DNA primase (EC 2.7.7.-) (Late expression factor 1)
1 entry
Tyrosine-protein phosphatase (EC 3.1.3.48) (BVP)
1 entry
Putative tyrosine-protein phosphatase 1 (Protein-tyrosine phosphatase 1) (EC 3.1.3.48)
1 entry
Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2)
16 entries
Polyhedrin (Major occlusion protein)
1 entry
Putative bifunctional polynucleotide kinase/RNA ligase
2 entries
Probable DNA-directed RNA polymerase subunit beta (EC 2.7.7.6) (Late expression factor 8)
2 entries
Putative superoxide dismutase
2 entries
Spheroidin-like protein (37 kDa glycoprotein) (Spindolin-like protein)
3 entries
Trans-activating transcriptional regulatory protein (Immediate early protein 1) (IE-1)
2 entries
Telokin-like protein 20
2 entries
Ubiquitin-like protein
6 entries
Ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-)
1 entry
ATP-dependent DNA helicase P143 (EC 3.6.4.12)
1 entry
Zinc finger protein CG30
2 entries
Early 18.5 kDa protein
1 entry
Putative early 21.8 kDa protein
1 entry
Early 39 kDa protein
1 entry
Putative early 40.3 kDa protein
1 entry
Early 94 kDa protein
5 entries
E3 ubiquitin-protein ligase IE2 (EC 2.3.2.27) (Immediate-early protein IE2) (RING-type E3 ubiquitin transferase IE2)
3 entries
Very late expression factor 1
1 entry
8.9 kDa basic protein
3 entries
Protein p10 (Fibrous body protein)
3 entries
Putative 15 kDa capsid protein
1 entry
GP16 protein
2 entries
P18 protein
1 entry
Capsid protein p24
1 entry
Occlusion-derived virus envelope protein E25 (P25 protein)
1 entry
33 kDa early protein (p33)
1 entry
Early 35 kDa protein (Apoptosis-preventing protein) (p35)
2 entries
Major capsid protein
2 entries
Structural glycoprotein p40
1 entry
Structural glycoprotein gp41
1 entry
43 kDa protein
2 entries
DNA-directed RNA polymerase subunit p47
1 entry
p48 protein
1 entry
61 kDa protein homolog
2 entries
Protein p74
1 entry
Capsid-associated protein VP80
1 entry
Capsid protein p87
4 entries
Capsid-associated protein Vp91
3 entries
Polyhedral envelope protein (PE) (Polyhedral calyx protein)
2 entries
Uncharacterized 10.2 kDa protein
2 entries
Uncharacterized 16.2 kDa protein (ORF8)
2 entries
Uncharacterized 12.4 kDa protein in CTL-LEF2 intergenic region (ORF5)
1 entry
Uncharacterized 23.6 kDa protein in LEF2-PH intergenic region (ORF603)
1 entry
Uncharacterized 37.2 kDa protein (ORF11)
1 entry
Uncharacterized 14.2 kDa protein in PK1-LEF1 intergenic region (ORF11)
2 entries
Uncharacterized 36.6 kDa protein (ORF12)
2 entries
Uncharacterized 11.6 kDa protein
1 entry
Uncharacterized 8.0 kDa protein in EGT-IAP1 intergenic region
2 entries
Uncharacterized 34.7 kDa protein
1 entry
Uncharacterized 43.4 kDa protein
1 entry
Uncharacterized 73.1 kDa protein (ORF21)
1 entry
Uncharacterized 18.4 kDa protein
2 entries
Uncharacterized 34.6 kDa protein
2 entries
Uncharacterized 14.4 kDa protein
2 entries
Uncharacterized 16.5 kDa protein
2 entries
Uncharacterized 8.5 kDa protein
2 entries
Uncharacterized 52.7 kDa protein
1 entry
Uncharacterized 20.8 kDa protein in FGF-VUBI intergenic region (ORF 1)
1 entry
Uncharacterized 24.0 kDa protein (ORF26)
1 entry
Uncharacterized 24.3 kDa protein (ORF22)
1 entry
Uncharacterized 19.0 kDa protein
1 entry
Uncharacterized 7.1 kDa protein
2 entries
Uncharacterized 13.0 kDa protein
2 entries
Uncharacterized 36.2 kDa protein
1 entry
Uncharacterized 14.9 kDa protein in LEF8-FP intergenic region
1 entry
Uncharacterized 17.0 kDa protein
1 entry
Uncharacterized 42.5 kDa protein
2 entries
Uncharacterized 8.0 kDa protein
2 entries
Uncharacterized 9.7 kDa protein
2 entries
Uncharacterized 18.9 kDa protein
1 entry
Uncharacterized 6.8 kDa protein in LEF8-FP intergenic region
2 entries
Uncharacterized 19.9 kDa protein
3 entries
Uncharacterized 10.1 kDa protein in LEF8-FP intergenic region
1 entry
Uncharacterized 18.5 kDa protein in FP-SLP intergenic region
1 entry
Uncharacterized 98.6 kDa protein
1 entry
Uncharacterized 15.4 kDa protein (ORF73)
1 entry
Uncharacterized 34.4 kDa protein in LEF3-IAP2 intergenic region
2 entries
Uncharacterized 6.3 kDa protein
2 entries
Uncharacterized 11.5 kDa protein in IAP2-VLF1 intergenic region
2 entries
Uncharacterized 19.5 kDa protein
1 entry
Uncharacterized 14.9 kDa protein
1 entry
Uncharacterized 9.4 kDa protein
1 entry
Uncharacterized 11.7 kDa protein
2 entries
UPF0213 protein ORF82
1 entry
Uncharacterized 24.9 kDa protein
1 entry
Uncharacterized 21.7 kDa protein in GP41-PNK intergenic region
2 entries
Uncharacterized 6.1 kDa protein
2 entries
Uncharacterized 24.1 kDa protein in LEF4-P33 intergenic region
1 entry
Uncharacterized 19.4 kDa protein (ORF97)
1 entry
Uncharacterized 6.5 kDa protein in P143-LEF5 intergenic region
1 entry
Uncharacterized 36.0 kDa protein
1 entry
Uncharacterized 12.2 kDa protein in P6.5-VP48 intergenic region (ORF2) (P12)
1 entry
Uncharacterized 7.1 kDa protein in HE65-PK2 intergenic region
2 entries
Uncharacterized 12.5 kDa protein in HE65-PK2 intergenic region
2 entries
Uncharacterized 11.7 kDa protein
1 entry
Uncharacterized 44.3 kDa protein
1 entry
Uncharacterized 6.7 kDa protein
2 entries
Uncharacterized 8.2 kDa protein
1 entry
Uncharacterized 10.5 kDa protein in HE65-PK2 intergenic region
1 entry
Uncharacterized 20.3 kDa protein in HE65-PK2 intergenic region
1 entry
Uncharacterized 48.2 kDa protein
1 entry
Uncharacterized 22.1 kDa protein
1 entry
Uncharacterized 6.4 kDa protein in HE65-PK2 intergenic region
2 entries
Uncharacterized 11.0 kDa protein in HE65-PK2 intergenic region
1 entry
Uncharacterized 18.7 kDa protein in HE65-PK2 intergenic region
1 entry
Uncharacterized 59.0 kDa protein
2 entries
Uncharacterized 9.3 kDa protein
2 entries
Uncharacterized 7.2 kDa protein in HE65-PK2 intergenic region
1 entry
Uncharacterized 26.5 kDa protein
1 entry
Uncharacterized 26.0 kDa protein in PP34-EXO intergenic region
1 entry
Uncharacterized 13.4 kDa protein in ubiquitin 3'region (Lambda 208)
1 entry
Uncharacterized 7.1 kDa protein in ME53-IE0 intergenic region
1 entry
Uncharacterized 55.8 kDa protein
1 entry
Uncharacterized 11.0 kDa protein
2 entries
Uncharacterized 21.8 kDa protein
1 entry
Uncharacterized 12.4 kDa protein in IE1-IEN intergenic region
1 entry
Uncharacterized 9.4 kDa protein in PE38 3'region
1 entry
Uncharacterized 7.9 kDa protein in PE 5'region (ORF1)
1 entry
Uncharacterized 9.2 kDa protein in PE 5'region (ORF2)
1 entry
Uncharacterized 9.7 kDa protein in PE 3'region (ORF 4)
1 entry
Uncharacterized 33.9 kDa protein in PE 3'region (ORF 6)
1 entry