Inhibition of host tetherin by virus

Tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles (VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response.

Several viruses manage to circumvent the antiviral activity of tetherin. The Vpu protein form HIV-1 bridges tetherin to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin, restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein.

Matching UniProtKB/Swiss-Prot entries

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61 entries grouped by protein (browse by keywords)

13 entries

Envelope glycoprotein gp160 (Env polyprotein)

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ENV_HV2BE
Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain
ENV_HV2EH
Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2) reference strain
ENV_HV2RO
Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) reference strain
ENV_HV2UC
Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2) reference strain
ENV_HV2CA
Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)
ENV_HV2D1
Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)
ENV_HV2D2
Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)
ENV_HV2G1
Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
ENV_HV2KR
Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)
ENV_HV2NZ
Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)
ENV_HV2S2
Human immunodeficiency virus type 2 subtype A (isolate ST/24.1C#2) (HIV-2)
ENV_HV2SB
Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)
ENV_HV2ST
Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)

2 entries

ORF7a protein (Accessory protein 7a) (Protein U122) (Protein X4)

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NS7A_SARS
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
NS7A_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4)

2 entries

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

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SPIKE_SARS
Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain
SPIKE_SARS2
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

pdb 6LVN; 6LXT; 6LZG; 6M0J; 6M17; 6M1V; 6VSB; 6VW1; 6VXX; 6VYB; 6W41; 6WPS; 6WPT; 6X29; 6X2A; 6X2B; 6X2C; 6X45; 6X6P; 6X79; 6XC2; 6XC3; 6XC4; 6XC7; 6XCM; 6XCN; 6XDG; 6XE1; 6XEY; 6XF5; 6XF6; 6XKL; 6XKP; 6XKQ; 6XLU; 6XM0; 6XM3; 6XM4; 6XM5; 6XR8; 6XRA; 6XS6; 6YLA; 6YM0; 6YOR; 6YZ5; 6YZ7; 6Z2M; 6Z43; 6Z97; 6ZB4; 6ZB5; 6ZBP; 6ZCZ; 6ZDG; 6ZDH; 6ZER; 6ZFO; 6ZGE; 6ZGG; 6ZGI; 6ZH9; 6ZHD; 6ZLR; 6ZOW; 6ZOX; 6ZOY; 6ZOZ; 6ZP0; 6ZP1; 6ZP2; 6ZP5; 6ZP7; 6ZWV; 6ZXN; 7A25; 7A29; 7A4N; 7A5R; 7A5S; 7A91; 7A92; 7A93; 7A94; 7A95; 7A96; 7A97; 7A98; 7AD1; 7AKD; 7B14; 7B17; 7B18; 7B3O; 7B62; 7BEH; 7BEI; 7BEJ; 7BEK; 7BEL; 7BEM; 7BEN; 7BEO; 7BEP; 7BH9; 7BNM; 7BNN; 7BNO; 7BWJ; 7BYR; 7BZ5; 7C01; 7C2L; 7C53; 7C8D; 7C8J; 7C8V; 7C8W; 7CAB; 7CAC; 7CAH; 7CAI; 7CAK; 7CAN; 7CDI; 7CDJ; 7CH4; 7CH5; 7CHB; 7CHC; 7CHE; 7CHF; 7CHH; 7CHO; 7CHP; 7CHS; 7CJF; 7CM4; 7CN4; 7CN9; 7CT5; 7CWL; 7CWM; 7CWN; 7CWO; 7CWS; 7CWT; 7CWU; 7CYH; 7CYP; 7CYV; 7CZP; 7CZQ; 7CZR; 7CZS; 7CZT; 7CZU; 7CZV; 7CZW; 7CZX; 7CZY; 7CZZ; 7D00; 7D03; 7D0B; 7D0C; 7D0D; 7D2Z; 7D30; 7D4G; 7D6I; 7DCC; 7DCX; 7DD2; 7DD8; 7DDD; 7DDN; 7DEO; 7DET; 7DEU; 7DF3; 7DF4; 7DHX; 7DJZ; 7DK0; 7DK2; 7DK3; 7DK4; 7DK5; 7DK6; 7DK7; 7DMU; 7DPM; 7DQA; 7DWX; 7DWY; 7DWZ; 7DX0; 7DX1; 7DX2; 7DX3; 7DX4; 7DX5; 7DX6; 7DX7; 7DX8; 7DX9; 7DZW; 7DZX; 7DZY; 7E23; 7E39; 7E3B; 7E3C; 7E3J; 7E3K; 7E3L; 7E3O; 7E5O; 7E5R; 7E5S; 7E5Y; 7E7B; 7E7D; 7E7X; 7E7Y; 7E86; 7E88; 7E8C; 7E8F; 7E8M; 7E9T; 7EAM; 7EAN; 7EAZ; 7EB0; 7EB3; 7EB4; 7EB5; 7EDF; 7EDG; 7EDH; 7EDI; 7EDJ; 7EFP; 7EFR; 7EH5; 7EJ4; 7EJ5; 7EK6; 7EKC; 7EKE; 7EKF; 7EKG; 7EKH; 7EY0; 7EY4; 7EY5; 7EYA; 7EZV; 7F62; 7F63; 7FAE; 7FAF; 7FCD; 7FCE; 7FDG; 7FDH; 7FDI; 7FDK; 7FEM; 7FET; 7FG2; 7FG3; 7FG7; 7JJC; 7JJI; 7JJJ; 7JMO; 7JMP; 7JMW; 7JV2; 7JV4; 7JV6; 7JVA; 7JVB; 7JVC; 7JW0; 7JWB; 7JWY; 7JX3; 7JZL; 7JZM; 7JZN; 7JZU; 7K43; 7K45; 7K4N; 7K8M; 7K8S; 7K8T; 7K8U; 7K8V; 7K8W; 7K8X; 7K8Y; 7K8Z; 7K90; 7K9H; 7K9I; 7K9J; 7K9K; 7K9Z; 7KDG; 7KDH; 7KDI; 7KDJ; 7KDK; 7KDL; 7KE4; 7KE6; 7KE7; 7KE8; 7KE9; 7KEA; 7KEB; 7KEC; 7KFV; 7KFW; 7KFX; 7KFY; 7KGJ; 7KGK; 7KJ2; 7KJ3; 7KJ4; 7KJ5; 7KKK; 7KKL; 7KL9; 7KLG; 7KLH; 7KLW; 7KM5; 7KMB; 7KMG; 7KMH; 7KMI; 7KMK; 7KML; 7KMS; 7KMZ; 7KN3; 7KN4; 7KN5; 7KN6; 7KN7; 7KNB; 7KNE; 7KNH; 7KNI; 7KQB; 7KQE; 7KRQ; 7KRR; 7KRS; 7KS9; 7KSG; 7KXJ; 7KXK; 7KZB; 7L02; 7L06; 7L09; 7L0N; 7L2C; 7L2D; 7L2E; 7L2F; 7L3N; 7L4Z; 7L56; 7L57; 7L58; 7L5B; 7L7D; 7L7E; 7L7F; 7L7K; 7LAA; 7LAB; 7LC8; 7LCN; 7LD1; 7LDJ; 7LJR; 7LM8; 7LO4; 7LOP; 7LQ7; 7LQV; 7LQW; 7LRS; 7LRT; 7LS9; 7LSS; 7LWI; 7LWJ; 7LWK; 7LWL; 7LWM; 7LWN; 7LWO; 7LWP; 7LWQ; 7LWS; 7LWT; 7LWU; 7LWV; 7LWW; 7LX5; 7LXW; 7LXX; 7LXY; 7LXZ; 7LY0; 7LY2; 7LY3; 7LYK; 7LYL; 7LYM; 7LYN; 7LYO; 7LYP; 7LYQ; 7M0J; 7M3I; 7M42; 7M53; 7M6D; 7M6E; 7M6F; 7M6G; 7M6H; 7M6I; 7M71; 7M7B; 7M7W; 7M8J; 7M8K; 7M8S; 7M8T; 7M8U; 7MDW; 7ME7; 7MEJ; 7MF1; 7MFU; 7MJG; 7MJH; 7MJI; 7MJJ; 7MJK; 7MJL; 7MJM; 7MJN; 7MKB; 7MKL; 7MKM; 7MLZ; 7MM0; 7MMO; 7MSQ; 7MTC; 7MTD; 7MTE; 7MY2; 7MY3; 7MY8; 7MZF; 7MZG; 7MZH; 7MZI; 7MZJ; 7MZK; 7MZL; 7MZM; 7MZN; 7N0G; 7N0H; 7N1A; 7N1B; 7N1E; 7N1F; 7N1Q; 7N1T; 7N1U; 7N1V; 7N1W; 7N1X; 7N1Y; 7N3I; 7N4I; 7N4J; 7N4L; 7N4M; 7N5H; 7N62; 7N64; 7N6D; 7N6E; 7N8H; 7N8I; 7N9A; 7N9B; 7N9C; 7N9E; 7N9T; 7NAB; 7ND3; 7ND4; 7ND5; 7ND6; 7ND7; 7ND8; 7ND9; 7NDA; 7NDB; 7NDC; 7NDD; 7NEG; 7NEH; 7NKT; 7NP1; 7NT9; 7NTA; 7NTC; 7NX6; 7NX7; 7NX8; 7NX9; 7NXA; 7NXB; 7NXC; 7OAN; 7OAO; 7OAP; 7OAQ; 7OAU; 7OAY; 7OD3; 7ODL; 7OLZ; 7OR9; 7ORA; 7ORB; 7P3D; 7P77; 7P78; 7P79; 7P7A; 7P7B; 7PRY; 7PRZ; 7PS0; 7PS1; 7PS2; 7PS4; 7PS5; 7PS6; 7PS7; 7Q0G; 7Q0H; 7Q0I; 7Q6E; 7Q9F; 7Q9G; 7Q9I; 7Q9J; 7Q9K; 7Q9M; 7Q9P; 7QO9; 7R6W; 7R6X; 7R7N; 7R8L; 7R8M; 7R8N; 7R8O; 7R95; 7RA8; 7RAL; 7RKU; 7RKV; 7RNJ; 7RPV; 7RR0; 7RTD; 7RTR; 7RW2; 7RXD; 7S0B; 7S0C; 7S0D; 7S0E; 7S4S; 7SBK; 7SBL; 7SBO; 7SBP; 7SBQ; 7SBR; 7SBS; 7SBT; 7SJS; 7SN2; 7SN3; 7SO9; 7SOA; 7SOB; 7SOC; 7SOD; 7SOE; 7SOF; 7SPO; 7SPP; 7SXR; 7SXS; 7SXT; 7SXU; 7SXV; 7SXW; 7SXX; 7SXY; 7SXZ; 7SY0; 7SY1; 7SY2; 7SY3; 7SY4; 7SY5; 7SY6; 7SY7; 7SY8; 7T9J; 7T9K; 7T9L; 7TAS; 7TAT; 7V26; 7V2A; 7V76; 7V77; 7V78; 7V79; 7V7A; 7V7D; 7V7E; 7V7F; 7V7G; 7V7H; 7V7I; 7V7J; 7V7N; 7V7O; 7V7P; 7V7Q; 7V7R; 7V7S; 7V7T; 7V7U; 7V7V; 7V7Z; 7V80; 7V81; 7V82; 7V83; 7V84; 7V85; 7V86; 7V87; 7V88; 7V89; 7V8A; 7V8B; 7V8C; 7VMU; 7VNB; 7VNC; 7VND; 7VNE; 7VX1; 7VX4; 7VX5; 7VX9; 7VXA; 7VXB; 7VXC; 7VXD; 7VXE; 7VXF; 7VXI; 7VXK; 7VXM; 7W92; 7W94; 7W98; 7W99; 7W9B; 7W9C; 7W9E; 7W9F; 7W9I; 7WBL; 7WBP; 7WBQ; 7WEV; 7WK2; 7WK3; 7WK8; 7WKA

11 entries

Envelope glycoprotein (GP1,2) (GP)

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VGP_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus) reference strain
VGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VGP_EBOEC
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
VGP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VGP_EBORS
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
VGP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
VGP_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
VGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VGP_TAFVC
Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

33 entries

Protein Vpu (U ORF protein) (Viral protein U)

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VPU_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain
VPU_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain
VPU_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain
VPU_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain
VPU_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain
VPU_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
VPU_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain
VPU_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain
VPU_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
VPU_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain
VPU_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
VPU_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1) reference strain
VPU_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
VPU_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain
VPU_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
VPU_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1) reference strain
VPU_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
VPU_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
VPU_HV1B8
Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)
VPU_HV1BN
Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)
VPU_HV1C4
Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)
VPU_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
VPU_HV1J3
Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)
VPU_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
VPU_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)
VPU_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)
VPU_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
VPU_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
VPU_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
VPU_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
VPU_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
VPU_HV1Z3
Human immunodeficiency virus type 1 group M subtype U (isolate Z3) (HIV-1)
VPU_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus)