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Inhibition of host TYK2 by virus (kw:KW-1112)

Tyrosine kinase 2 TYK2 is a member of IFNα/β signaling that belongs to the Janus kinase (JAK) family. Activation of TYK2 by IFNα/β stimulation leads to a series of phosphorylation events, causing the formation of IFN stimulated gene factor 3 (ISGF3) complexes that consist of STAT1, STAT2 and IFN regulatory factor 9 IRF9. Subsequently, ISGF3 translocates to the nucleus and binds to IFN stimulated response elements (IRF/ISRE), which in turn activates transcription of several hundred IFN-responsive genes.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6

Several viruses have evolved mechanisms to inhibit TYK2 activity and prevent the subsequent activation of downstream partners STAT1 and STAT2. The Epstein-Barr virus LMP-1 protein interacts with TYK2 and prevents its phosphorylation. Human papillomavirus E6 also interacts with and impair TYK2 activation.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of interferon signaling Inhibition of host STAT1
Inhibition of host STAT2
Inhibition of host IRF9
Inhibition of host TYK2
Inhibition of host JAK1
Inhibition of host interferon receptors
Links Uniprot Keyword: KW-1112
GO ontology: GO:0039574
Virus -Hepatitis delta virus
(Unassigned, Deltavirus)

-Epstein-Barr virus
(Herpesviridae, Lymphocryptovirus)

Myxomavirus
(Poxviridae, Leporipoxvirus)

-HPV18
(Papillomaviridae, alphapapillomavirus)

Japanese encephalitis virus
(Flaviviridae, Flavivirus)

Dengue virus
(Flaviviridae, Flavivirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

41 entries grouped by strain

2 entries

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
CEP2_EBVA8 Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)
LMP1_EBVA8 Latent membrane protein 1 (LMP-1) (Protein p63)

2 entries

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

Select_allDeselect_all
LMP1_EBVB9 Latent membrane protein 1 (LMP-1) (Protein p63) [Cleaved into: Protein p25]

pdb 1CZY

CEP2_EBVB9 Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 3J8D; 3L6P; 3LKW; 4AL8; 4GSX; 4GT0; 4LCY; 4OIG; 5VIC; 5WJL; 5WKF; 7DWT; 7DWU; 8VPR

1 entry

Zika virus (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GJ4; 5GPI; 5GXJ; 5JPS; 5JRZ; 5K6K; 5RHG; 5RHH; 5RHI; 5RHJ; 5RHK; 5RHL; 5RHM; 5RHO; 5RHP; 5RHQ; 5RHR; 5RHS; 5RHT; 5RHU; 5RHV; 5RHW; 5RHX; 5RHY; 5T1V; 5TFN; 5TFO; 5TFR; 5TMH; 5U04; 5U0B; 5U0C; 5VI7; 5VIM; 5W41; 5Y4Z; 5YOD; 5YOF; 5Z0R; 5Z0V; 5ZMQ; 5ZMS; 5ZOB; 6ADW; 6ADX; 6ADY; 6JPW; 6KK2; 6KK3; 6KK4; 6KK5; 6KK6; 6KPQ; 6L50; 6MH3; 6UX2; 6WCZ; 6Y3B; 7G9K; 7G9L; 7G9M; 7G9N; 7G9O; 7G9P; 7G9Q; 7G9R; 7G9S; 7G9T; 7G9U; 7G9V; 7G9W; 7G9X; 7G9Y; 7G9Z; 7GA0; 7GA1; 7GA2; 7GA3; 7GA4; 7GA5; 7GA6; 7GA7; 7H1H; 7H1I; 7H1J; 7H1K; 7H1L; 7H1M; 7H1N; 7H1O; 7H1P; 7H1Q; 7H1R; 7H1S; 7H1T; 7H1U; 7H1V; 7H1W; 7H1X; 7H1Y; 7H1Z; 7H20; 7H21; 7H22; 7H23; 7H24; 7H25; 7H26; 7H27; 7H28; 7H29; 7H2A; 7H2B; 7H2C; 7H2D; 7H2E; 7H2F; 7H2G; 7H2H; 7H2I; 7H2J; 7H2K; 7H2L; 7H2M; 7H2N; 7H2O; 7H2P; 7H2Q; 7H2R; 7H2S; 7HOJ; 7HOK; 7HOL; 7HOM; 7HOP; 7HOQ; 7HOR; 7HOS; 7HOT; 7HOU; 7HOV; 7HOW; 7HOX; 7HOZ; 7HP0; 7HP1; 7HP2; 7HP4; 7HP5; 7HP6; 7HP7; 7HP8; 7HP9; 7HPA; 7HPB; 7HPC; 7HPD; 7HPE; 7HPF; 7HPG; 7HPH; 7I1K; 7I1L; 7I1M; 7I1N; 7I1O; 7I1P; 7I1Q; 7I1S; 7I1T; 7I1V; 7I1W; 7I1Y; 7I1Z; 7I20; 7I21; 7I22; 7O2M; 7O55; 7OBV; 7OC2; 7PFQ; 7PFY; 7PFZ; 7PG1; 7PGC; 7VLG; 7VLH; 7VLI; 7VXX; 7VXY; 7ZLC; 7ZLD; 7ZMI; 7ZNO; 7ZPD; 7ZQ1; 7ZQF; 7ZTM; 7ZUM; 7ZV4; 7ZVV; 7ZW5; 7ZWK; 7ZYS; 8A15; 8AQA; 8AQB; 8AQK; 8PEM; 8PN6; 8UM3; 8V7R; 8V7U; 8WN8; 8WNP; 8WNU; 8WO0; 8WO4

2 entries

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

Select_allDeselect_all
LMP1_EBVG Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 8XH6; 8XH7

CEP2_EBVG Cytoplasmic envelopment protein 2 (Tegument protein BGLF2)

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope ...

pdb 3UZQ

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3L6P; 3LKW

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1P58; 2M9P; 2M9Q; 3C6D

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2R29; 3EVG; 6FLA

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3UZV; 6VG5; 6VSO

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3IXY

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1L9K; 1OAN; 1OK8; 1OKE; 1P58; 1R6A; 1R6R; 1THD; 2P1D; 2P3L; 2P3O; 2P3Q; 2P40; 2P41; 3J8D; 3ZKO; 4M9F; 4M9I; 4M9K; 4M9M; 4M9T; 5HHG

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2R69; 4O6B; 6WER; 6WY1; 6ZQU; 7K93

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3IYA; 3J27; 3J2P; 4CBF; 4UIH; 6FLA; 6FLB; 6FLC; 6IZX; 6IZY; 9DOF; 9DOG; 9DTT

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 1UZG; 2J7U; 2J7W; 3P8Z; 3P97; 3UZE; 3VTT; 5CCV; 5E9Q; 5EC8; 5EHG; 5EHI; 5EIF; 5EIW; 5EKX; 7A3S; 7A3T

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 3U1I; 3U1J; 4CTJ; 4CTK; 4V0Q; 4V0R

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2J7U; 2J7W; 3VWS; 4C11; 4HHJ; 5DTO; 5EIW; 5F3T; 5F3Z; 5F41; 5HMW; 5HMX; 5HMY; 5HMZ; 5HN0; 5I3P; 5I3Q; 5IQ6; 5JJR; 5JJS; 5WJN; 5WKH; 6H80; 6H9R; 6XD0; 6XD1

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2H0P; 3UAJ; 3UC0; 3WE1; 4X42; 5B1C; 7A3Q

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 4AM0; 7VMV; 8WBB; 8WBC; 8WBD; 8WBE

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2JLQ; 2JLR; 2JLS; 2JLU; 2JLV; 2JLW; 2JLX; 2JLY; 2JLZ; 2WHX; 2WZQ; 3UYP; 5YVV; 5YVW

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)

LMP1_EBVC Latent membrane protein 1 (LMP-1) (Protein p63)

1 entry

Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

LMP1_EBVR Latent membrane protein 1 (LMP-1) (Protein p63)

pdb 1ZMS

1 entry

Japanese encephalitis virus (strain Jaoars982) (JEV)

POLG_JAEVJ Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 5YWO; 5YWP

1 entry

Japanese encephalitis virus (strain M28) (JEV)

POLG_JAEVM Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA(v)) (JEV)

POLG_JAEV5 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

1 entry

Japanese encephalitis virus (strain SA-14) (JEV)

POLG_JAEV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small ...

pdb 2Z83; 3P54; 4HDG; 4HDH; 4K6M; 4MTP; 5MV1; 5MV2; 5O19; 5O36; 5OW2; 5WSN; 5YWO; 5YWP

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1SFK; 2HCN; 2HCS; 2HFZ; 2OF6; 2QEQ

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 1Z66; 2GG1; 7WNJ; 8YNJ; 9FK0; 9H28

1 entry

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

V_MEASA Non-structural protein V

1 entry

Rinderpest virus (strain RBOK) (RDV)

V_RINDR Non-structural protein V

1 entry

Usutu virus (USUV)

POLG_USUV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 6A0P; 6S92; 6S93; 6S94; 8B51; 8B52

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); Protein prM; Peptide ...

pdb 2FP7; 2GGV; 2IJO; 2P5P; 2YOL; 3E90; 3I50; 5IDK

1 entry

Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)

POLG_ZIKVF Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM ...

pdb 5GOZ; 5GP1; 5H30; 5H32; 5H37; 5IRE; 5IZ7; 5JMT; 5KQR; 5KQS; 5KVE; 5LBS; 5LBV; 5LCV; 5M5B; 5MRK; 5NJU; 5NJV; 5U4W; 5UHY; 5ULP; 5Y0A; 5Y6M; 5Y6N; 6CO8; 6I7P; 6JFH; 6JFI; 6LD1; 6LD2; 6LD3; 6LD4; 6LD5; 6NIP; 6NIU; 6PLK; 6RWZ; 6S0J; 6UM3; 7A3N; 7A3U; 7BSD; 7BU8; 7BUA; 7M1V; 7T17; 7V2Z; 7YAR; 7YW7; 7YW8; 8EE5; 8EE8; 8EED; 8EEE