Inhibition of host TYK2 by virus (kw:KW-1112)

Tyrosine kinase 2 TYK2 is a member of IFNα/β signaling that belongs to the Janus kinase (JAK) family. Activation of TYK2 by IFNα/β stimulation leads to a series of phosphorylation events, causing the formation of IFN stimulated gene factor 3 (ISGF3) complexes that consist of STAT1, STAT2 and IFN regulatory factor 9 IRF9. Subsequently, ISGF3 translocates to the nucleus and binds to IFN stimulated response elements (IRF/ISRE), which in turn activates transcription of several hundred IFN-responsive genes.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6

Several viruses have evolved mechanisms to inhibit TYK2 activity and prevent the subsequent activation of downstream partners STAT1 and STAT2. The Epstein-Barr virus LMP-1 protein interacts with TYK2 and prevents its phosphorylation. Human papillomavirus E6 also interacts with and impair TYK2 activation.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

0 entry grouped by strain