Inhibition of host ISG15 by virus

The ISG15(M21786:9606) protein is a ubiquitin-like modifier induced by interferon, which induces modification and somehow inhibits cellular and viral proteins . Like ubiquitin(AB062071:9606) , ISG15(M21786:9606) is conjugated to lysines on numerous target proteins through its conserved C-terminal region. This reaction is mediated by specific E1-activating, E2-conjugating, and E3-ligase enzymes, all of which are also IFN-inducible.

INFRA1 INFRA2 JAK1 TYK2 STAT2 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 sars E3 STAT1 STAT2 IRF9 IRF9 IRF9 NS1 ISG15

Viruses escape from the antiviral activity of ISG15(M21786:9606) by using different mechanisms. The influenza B virus NS1 protein(P03502) for instance blocks the covalent linkage of ISG15(M21786:9606) to its target proteins by directly interacting with ISG15(M21786:9606). The papain-like protease(P0C6X7) from the severe acute respiratory syndrome coronavirus cleaves ISG15(M21786:9606) derivatives.

Matching UniProtKB/Swiss-Prot entries

67 entries grouped by protein (browse by keywords)

All proteins are shown (view only 51 complete proteome entries)

3 entries

Protein E3 (p25)

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E3_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
E3_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

Protein E3

E3_VACCC
Vaccinia virus (strain Copenhagen) (VACV)

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_CCHFI
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV) reference strain
L_DUGBA
Dugbe virus (isolate ArD44313) (DUGV) reference strain

16 entries

Non-structural protein 1 (NS1) (NS1A)

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NS1_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
NS1_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
NS1_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
NS1_INBBA
Influenza B virus (strain B/BA/1978)
NS1_INBGA
Influenza B virus (strain B/GA/1986)
NS1_INBGL
Influenza B virus (strain B/GL/1954)
NS1_INBHK
Influenza B virus (strain B/Hong Kong/8/1973)
NS1_INBHT
Influenza B virus (strain B/HT/1984)
NS1_INBID
Influenza B virus (strain B/ID/1986)
NS1_INBMD
Influenza B virus (strain B/Maryland/1959)
NS1_INBPA
Influenza B virus (strain B/PA/1979)
NS1_INBRU
Influenza B virus (strain B/RU/1969)
NS1_INBSI
Influenza B virus (strain B/Singapore/222/1979)
NS1_INBSJ
Influenza B virus (strain B/Singapore/1964)
NS1_INBVJ
Influenza B virus (strain B/Victoria/1987)
NS1_INBYA
Influenza B virus (strain B/Yamagata/1/1973)

20 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

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R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1) (Human coronavirus EMC) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

20 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

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R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (Betacoronavirus England 1) (Human coronavirus EMC) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

6 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

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RPOA_EAVBU
Equine arteritis virus (strain Bucyrus) (EAV) reference strain
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)