Alphatorquevirus

VIRION

Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm..

GENOME

Circular ssDNA genome (-) of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a “Rep-like” protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

6 entries

Capsid protein

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CAPSD_TTVA1
Torque teno virus 1 (isolate TA278) reference strain
CAPSD_TTVV3
Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain
CAPSD_TTVV4
Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain
CAPSD_TTVV6
Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain
CAPSD_TTVV8
Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain
CAPSD_TTVV9
Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

1 entry

ORF1/1 protein

ORF11_TTVV3
Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

1 entry

ORF1/2 protein

ORF12_TTVV3
Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

3 entries

Uncharacterized ORF2 protein

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ORF2_TTVA1
Torque teno virus 1 (isolate TA278) reference strain
ORF2_TTVV3
Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

ORF2 protein

ORF2_TTVV8
Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

2 entries

Probable protein VP2 (ORF2/3 protein)

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ORF23_TTVV4
Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain
ORF23_TTVV6
Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

3 entries

Uncharacterized ORF2/4 protein

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ORF24_TTVV3
Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

ORF2/4 protein

ORF24_TTVV4
Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain
ORF24_TTVV6
Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

1 entry

Uncharacterized ORF2 protein

YORF2_TTVV9
Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

1 entry

Uncharacterized ORF3 protein

YORF3_TTVV9
Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain