Pneumoviridae

VIRION

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Enveloped, spherical. Diameter from about 150nm nm.

GENOME

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Negative-stranded RNA linear genome, about 13-15 kb in size. Encodes for 8 to 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

112 entries grouped by strain (browse by keywords)

11 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
L_BRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
GLYC_BRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
SH_BRSVA Small hydrophobic protein (Small protein 1A)
M21_BRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
MATRX_BRSVA Matrix protein (M protein)
PHOSP_BRSVA Phosphoprotein (Protein P)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
M22_BRSVA Protein M2-2

11 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
FUS_HRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
PHOSP_HRSVA Phosphoprotein (Protein P)
GLYC_HRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
M21_HRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)
SH_HRSVA Small hydrophobic protein (Small protein 1A)
MATRX_HRSVA Matrix protein (M protein)
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
L_HRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
M22_HRSVA Protein M2-2

11 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening ...
L_HRSVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
SH_HRSVB Small hydrophobic protein (Small protein 1A)
GLYC_HRSVB Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
MATRX_HRSVB Matrix protein (M protein)
M21_HRSVB Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_HRSVB Phosphoprotein (Protein P)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)
M22_HRSVB Protein M2-2

9 entries

Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain

Select_allDeselect_all
L_AMPV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_AMPV1 Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
VGLG_AMPV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
SH_AMPV1 Small hydrophobic protein
M21_AMPV1 Protein M2-1 (Envelope-associated 22 kDa protein)
M22_AMPV1 Protein M2-2
MTRX_AMPV1 Matrix protein
PHOSP_AMPV1 Phosphoprotein
NCAP_AMPV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

9 entries

Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Select_allDeselect_all
L_HMPVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M21_HMPVC Protein M2-1 (Envelope-associated 22 kDa protein)
VGLG_HMPVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
FUS_HMPVC Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
SH_HMPVC Small hydrophobic protein
MATRX_HMPVC Matrix protein (M protein)
PHOSP_HMPVC Phosphoprotein (Protein P)
M22_HMPVC Protein M2-2
NCAP_HMPVC Nucleoprotein (Protein N) (Nucleocapsid protein)

8 entries

Murine pneumonia virus (strain 15) (MPV) reference strain

Select_allDeselect_all
L_MPV15 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_MPV15 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
M21_MPV15 Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
MATRX_MPV15 Matrix protein (M protein)
NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)
NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)
PHOSP_MPV15 Phosphoprotein (Protein P)

7 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
FUS_HRSV1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
GLYC_HRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
SH_HRSV1 Small hydrophobic protein (Small protein 1A)
NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)
PHOSP_HRSV1 Phosphoprotein (Protein P)

7 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Select_allDeselect_all
GLYC_ORSVW Major surface glycoprotein G (Attachment glycoprotein G)
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)
NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)
M21_ORSVW Protein M2-1 (Envelope-associated 22 kDa protein)
PHOSP_ORSVW Phosphoprotein (Protein P)
NCAP_ORSVW Nucleoprotein (Protein N) (Nucleocapsid protein)
MATRX_ORSVW Matrix protein (M protein)

6 entries

Human respiratory syncytial virus A (strain Long)

Select_allDeselect_all
GLYC_HRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
L_HRSVL RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_HRSVL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
PHOSP_HRSVL Phosphoprotein (Protein P)
NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

5 entries

Turkey rhinotracheitis virus (TRTV)

Select_allDeselect_all
FUS_TRTV Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
M21_TRTV Protein M2-1 (Envelope-associated 22 kDa protein)
VGLG_TRTV Major surface glycoprotein G (Attachment glycoprotein G)
MATRX_TRTV Matrix protein (M protein)
SH_TRTV Small hydrophobic protein

3 entries

Bovine respiratory syncytial virus (strain Rb94) (BRS)

Select_allDeselect_all
FUS_BRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
GLYC_BRSVR Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

3 entries

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Select_allDeselect_all
SH_HRSS2 Small hydrophobic protein (Small protein 1A)
MATRX_HRSS2 Matrix protein (M protein)
NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

2 entries

Bovine respiratory syncytial virus (strain 391-2) (BRS)

Select_allDeselect_all
SH_BRSV3 Small hydrophobic protein (Small protein 1A)
NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

2 entries

Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

Select_allDeselect_all
FUS_BRSVC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
GLYC_BRSVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

2 entries

Human respiratory syncytial virus B (strain 8/60)

Select_allDeselect_all
GLYC_HRSV8 Major surface glycoprotein G (Attachment glycoprotein G) [Cleaved into: Mature secreted glycoprotein ...
SH_HRSV8 Small hydrophobic protein (Small protein 1A)

1 entry

Bovine respiratory syncytial virus (strain 127) (BRS)

GLYC_BRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 220-60) (BRS)

GLYC_BRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 220-69) (BRS)

GLYC_BRSV9 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 375) (BRS)

GLYC_BRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 4642) (BRS)

GLYC_BRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Lelystad) (BRS)

GLYC_BRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Snook) (BRS)

GLYC_BRSVS Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Wbh) (BRS)

GLYC_BRSVW Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus

PHOSP_HRSV Phosphoprotein (Protein P)

1 entry

Human respiratory syncytial virus A (strain RSS-2)

FUS_HRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

1 entry

Human respiratory syncytial virus A (strain rsb1734)

GLYC_HRSV3 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb5857)

GLYC_HRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6190)

GLYC_HRSV5 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6256)

GLYC_HRSV6 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb642)

GLYC_HRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6614)

GLYC_HRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...