Inhibition of host interferon receptors by virus

Type I interferons play an essential role in maintaining a defense against viral infection. These cytokines also participate in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. IFN receptors (IFN-R) are composed of two chains, α and β, and transduce signals via the classical Jak-Stat pathway.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 K3

Several viruses induce the ER stress response also named the unfolded protein response (UPR). Such activation requires the endoplasmic reticulum resident protein kinase PERK. The activation of this pathway promotes phosphorylation- dependent ubiquitination and degradation of IFNAR1, specifically inhibiting type I IFN signaling and antiviral defenses.

Matching UniProtKB/Swiss-Prot entries

3 entries grouped by protein (browse by keywords)

1 entry

Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)

AP3A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

1 entry

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

MIR1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)

MIR2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain