Inhibition of host RIG-I by virus

Upon viral infection, the cellular cytosolic receptor RIG-I recognizes viral RNA in a 5'-triphosphate-dependent manner and initiates an antiviral signaling cascade characterized by expression of antiviral cytokines and interferons. The RIG-I protein belongs to the helicase family and the interaction with its downstream adaptor molecule MAVS is triggered by RIG-I ubiquitination mediated by TRIM25.

Z NS1 NS2 RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF2 TRAF6 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Many viruses encode proteins that directly interfere with RIG-I to inhibit interferon production. A specific viral protease encoded by Poliovirus termed the 3Cpro cleaves RIG-I and abrogates its activity. This cleavage is likely to occur in all picornaviruses image. The Z protein of new world arenaviruses directly binds RIG-I and interferes with type I interferon production. The interaction blocks RIG-I interaction with MAVS, the downstream partner in the cascade. Other viral proteins targeting RIG-I include NS2 form HRSV or G protein from human metapneumovirus.


Table 1. Viruses recognized by host RIG-I and mechanisms of evasion employed to counteract the immune response initiated by RIG-I.

Virus Family Method of evasion Viral agent References
Respiratory syncytial virus Paramyxoviridae, Pneumovirus Direct interaction with RIG-I NS2
Rabies virus Rhabdoviridae, Lyssavirus Protect RNA from RIG-I recognition Nucleoprotein
Influenza A virus Orthomyxoviridae, Influenzavirus A Prevent RIG-I ubiquitination NS1
New world arenaviruses Arenaviridae, Arenavirus Direct interaction with RIG-I Z
Hantaan virus Bunyaviridae, Hantavirus Processing of viral genome 5' termini -
Crimean-Congo hemorrhagic fever virus Bunyaviridae, Nairovirus Processing of viral genome 5' termini -
Borna disease virus Bornaviridae, Bornavirus Processing of viral genome 5' termini -
Dengue virus Flaviviridae, Flavivirus Inactivation of TRIM25 Subgenomic Flavivirus RNA (sfRNA)


Table 2. Other viruses recognized by host RIG-I.

Virus Family References
Rift valley virus Bunyaviridae, Phlebovirus
Vesicular stomatitis virus Rhabdoviridae, Vesiculovirus
Sendai virus Paramyxoviridae, Respirovirus
Measles virus Paramyxoviridae, Morbillivirus
New Castle disease virus Paramyxoviridae, Respirovirus
Ebola virus Filoviridae, Ebolavirus
Nipah virus Paramyxoviridae, Henipavirus
Old world arenaviruses Arenaviridae, Arenavirus
Influenza B virus Orthomyxoviridae, Influenza B virus

Matching UniProtKB/Swiss-Prot entries

190 entries grouped by strain (browse by keywords)

2 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

Select_allDeselect_all
RNB_HHV11 Accessory factor US11 (Vmw21)
ITP_HHV11 Inner tegument protein (EC 3.5.1.-) (EC 3.5.1.44) (Viral deamidase UL37)

2 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)

1 entry

Encephalomyocarditis virus (strain Rueckert) (EMCV) reference strain

POLG_EMCVR Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Hepatitis C virus genotype 1a (isolate H77) (HCV) reference strain

F_HCV77 F protein (Alternate reading frame protein/F-protein) (ARFP/F) (Frameshifted protein) (p16) (p17)

1 entry

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

RNB_HHV2H Probable RNA-binding protein

1 entry

Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

VGLG_HMPVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain

POLG_HRV8A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

NS1_I96A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6) reference strain

NS1_I80AD Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

NS1_I34A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2) reference strain

NS1_I80A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza C virus (strain C/Ann Arbor/1/1950) reference strain

NS1_INCAA Non-structural protein 1 (NS1) (NS1A)

1 entry

Murine pneumonia virus (strain 15) (MPV) reference strain

NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)

1 entry

Poliovirus type 1 (strain Mahoney) reference strain

POLG_POL1M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

POLG_SVV1 Genome polyprotein [Cleaved into: Leader protein; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 ...

1 entry

Toscana virus (Tos) reference strain

NSS_TOSV Non-structural protein NS-S

2 entries

Human respiratory syncytial virus A (strain Long)

Select_allDeselect_all
NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

2 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

2 entries

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

Select_allDeselect_all
NS2_ORSVW Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_ORSVW Non-structural protein 1 (Non-structural protein 1C)

1 entry

Bovine enterovirus (strain VG-5-27) (BEV)

POLG_BOVEV Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A21 (strain Coe)

POLG_CXA21 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A24 (strain EH24/70)

POLG_CXA24 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A9 (strain Griggs)

POLG_CXA9 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B1 (strain Japan)

POLG_CXB1J Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid ...

1 entry

Coxsackievirus B2 (strain Ohio-1)

POLG_CXB2O Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Nancy)

POLG_CXB3N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B3 (strain Woodruff)

POLG_CXB3W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain E2)

POLG_CXB4E Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B4 (strain JVB / Benschoten / New York/51)

POLG_CXB4J Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B5 (strain Peterborough / 1954/UK/85)

POLG_CXB5P Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus B6 (strain Schmitt)

POLG_CXB6S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)

POLG_EC01F Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 11 (strain Gregory)

POLG_EC11G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 12 (strain Travis)

POLG_EC12T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 30 (strain Bastianni)

POLG_EC30B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 5 (strain Noyce)

POLG_EC05N Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 6 (strain Charles)

POLG_EC06C Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Barty)

POLG_EC09B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Echovirus 9 (strain Hill)

POLG_EC09H Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Encephalomyocarditis virus

POLG_EMCV Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Encephalomyocarditis virus (strain emc-b nondiabetogenic)

POLG_EMCVB Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Encephalomyocarditis virus (strain emc-d diabetogenic)

POLG_EMCVD Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Human enterovirus 70 (strain J670/71) (EV70) (EV-70)

POLG_HE701 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (EV71) (EV-71)

POLG_HE71 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain 7423/MS/87) (EV71) (EV-71)

POLG_HE71M Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human enterovirus 71 (strain USA/BrCr/1970) (EV71) (EV-71)

POLG_HE71B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNB_HHV1M RNA-binding protein (Vmw21)

1 entry

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

1 entry

Human rhinovirus 14 (HRV-14)

POLG_HRV14 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 16 (HRV-16)

POLG_HRV16 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1A (HRV-1A)

POLG_HRV1A Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 1B (HRV-1B)

POLG_HRV1B Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 2 (HRV-2)

POLG_HRV2 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Human rhinovirus 3 (HRV-3)

POLG_HRV3 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Influenza A virus (strain A/Aichi/2/1968 H3N2)

NS1_I68A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Alaska/6/1977 H3N2)

NS1_I77A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Anas acuta/Primorje/695/1976 H2N3)

NS1_I76A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

NS1_I60A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Beijing/352/1989 H3N2)

NS1_I89A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Beijing/39/1975 H3N2)

NS1_I75A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Brazil/11/1978 H1N1)

NS1_I77AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

NS1_I18A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)

NS1_I77AG Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)

NS1_I02A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Germany/n/1949 H10N7)

NS1_I49A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

NS1_I97A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

NS1_I02A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

NS1_I02A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

NS1_I01A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

NS1_I02A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)

NS1_I01A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

NS1_I02A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)

NS1_I01A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

NS1_I83A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)

NS1_I83A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

NS1_I59A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

NS1_I03A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

NS1_I85A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Chile/1/1983 H1N1)

NS1_I83A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

NS1_I96A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5)

NS1_I76A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

NS1_I56A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

NS1_I56A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

NS1_I49A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

NS1_I80A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

NS1_I00A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/England/878/1969 H3N2)

NS1_I69A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)

NS1_I91A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)

NS1_I89A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/London/1416/1973 H7N7)

NS1_I73A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)

NS1_I77A9 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)

NS1_I56A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)

NS1_I86A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)

NS1_I47A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fort Warren/1/1950 H1N1)

NS1_I50A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)

NS1_I34A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

NS1_I79A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)

NS1_I02A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)

NS1_I78AF Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

NS1_I77AF Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)

NS1_I80AC Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Henry/1936 H1N1)

NS1_I36A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Herring gull/DE/677/1988 H2N8)

NS1_I88A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hickox/1940 H1N1)

NS1_I40A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

NS1_I68A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

NS1_I97A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

NS1_I03A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

NS1_I83A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/India/6263/1980 H1N1)

NS1_I80AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Japan/305/1957 H2N2)

NS1_I57A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Korea/426/1968 H2N2)

NS1_I68A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/1/1954 H1N1)

NS1_I54A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

NS1_I57A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

NS1_I57A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

NS1_I57A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

NS1_I54A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Alberta/827/1978 H8N4)

NS1_I78A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Alberta/88/1976 H3N8)

NS1_I76A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

NS1_I78A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/New York/6874/1978 H3N2)

NS1_I78A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Mallard/Ohio/556/1987 H5N9)

NS1_I87A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/1/1971 H3N2)

NS1_I71A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/101/1972 H3N2)

NS1_I72A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/102/1972 H3N2)

NS1_I72A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/110/1976 H3N2)

NS1_I76A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/18/1978 H3N2)

NS1_I78A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/2/1978 H3N2)

NS1_I78A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Memphis/4/1980 H3N2)

NS1_I80A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)

NS1_I00A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)

NS1_I79A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/121/1979 H7N8)

NS1_I79A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/268/1978 H6N2)

NS1_I78AA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Pintail/Alberta/358/1979 H3N6)

NS1_I79A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

NS1_I73A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Qu/7/1970 H3N2)

NS1_I70A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)

NS1_I85A7 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

NS1_I06A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

NS1_I80A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)

NS1_I82A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)

NS1_I72A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

NS1_I01A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

NS1_I02A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Singapore/1/1957 H2N2)

NS1_I57A5 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

NS1_I77A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

NS1_I30A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

NS1_I61A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Tern/Turkmenia/18/1972 H3N3)

NS1_I72A6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

NS1_I67A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Bethlehem-Glilit/1492-B/1982 H1N1)

NS1_I82A8 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Canada/1963 H6N8)

NS1_I63A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

NS1_I83A4 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)

NS1_I78AC Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

NS1_I68A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)

NS1_I66A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)

NS1_I71A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

NS1_I66A1 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

NS1_I51A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

NS1_I45A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

NS1_I43A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

NS1_I96A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Phila/1935 H1N1)

NS1_I35A3 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)

NS1_I07A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/USSR/90/1977 H1N1)

NS1_I77AB Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Udorn/307/1972 H3N2)

NS1_I72A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Wa-182)

NS1_I000W Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Whale/Maine/328/1984 H13N2)

NS1_I84A2 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

NS1_I33A0 Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza A virus (strain A/X-31 H3N2)

NS1_I000X Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza C virus (strain C/California/1978)

NS1_INCCA Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza C virus (strain C/Hyogo/1/1983)

NS1_INCHY Non-structural protein 1 (NS1) (NS1A)

1 entry

Influenza C virus (strain C/Yamagata/1964)

NS1_INCY6 Non-structural protein 1 (NS1) (NS1A)

1 entry

Mengo encephalomyocarditis virus

POLG_ENMGO Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Poliovirus type 1 (strain Sabin)

POLG_POL1S Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain Lansing)

POLG_POL2L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 2 (strain W-2)

POLG_POL2W Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Poliovirus type 3 (strain 23127)

POLG_POL32 Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

POLG_POL3L Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Porcine enterovirus 9 (strain UKG/410/73)

POLG_PEV9U Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain H/3 '76) (SVDV)

POLG_SVDVH Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Swine vesicular disease virus (strain UKG/27/72) (SVDV)

POLG_SVDVU Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

POLG_TMEVG Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein ...