Morbillivirus

VIRION

Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and “polyadenylated” by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 90 entries)

8 entries

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

Select_allDeselect_all
PHOSP_MEASC Phosphoprotein (Protein P)
NCAP_MEASC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
L_MEASC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_MEASC Matrix protein
C_MEASC Protein C
HEMA_MEASC Hemagglutinin glycoprotein
FUS_MEASC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_MEASC Non-structural protein V

2 entries

Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Select_allDeselect_all
NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein)
L_CDVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

8 entries

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
NCAP_MEASA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASA Phosphoprotein (Protein P)
L_MEASA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_MEASA Matrix protein
C_MEASA Protein C
HEMA_MEASA Hemagglutinin glycoprotein
FUS_MEASA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_MEASA Non-structural protein V

7 entries

Rinderpest virus (strain RBOK) (RDV)

Select_allDeselect_all
PHOSP_RINDR Phosphoprotein (Protein P)
NCAP_RINDR Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
L_RINDR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_RINDR Matrix protein
C_RINDR Protein C
HEMA_RINDR Hemagglutinin glycoprotein
FUS_RINDR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

6 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
NCAP_MEASE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
L_MEASE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_MEASE Matrix protein
FUS_MEASE Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HEMA_MEASE Hemagglutinin glycoprotein
V_MEASE Non-structural protein V

1 entry

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Peste-des-petits-ruminants virus (PPRV)

NCAP_PPRV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)