Inhibition of host adaptive immune response by virus (kw:KW-1080)

Unlike innate immune response, which remain essentially unchanged upon exposure to a recurrent challenge with the same stimulus, adaptive immune cells possess the ability to learn and remember. Adaptive immunity relies on the capacity of immune cells to distinguish between the body's own cells and unwanted invaders. Healthy cells present peptides from normal cellular proteins on their cell surface, and lymphocytes will not be activated in response to them. When a cell is infected by viruses or other pathogens, the foreign peptides generated are recognized by lymphocytes that are activated and destroy the infected cell.

Viruses employ different strategies to inhibit presentation of viral-derived peptides. One way consists of the modulation of proteasome activity which generate the peptides from full-length proteins. Some viruses also directly interact with and inhibit the machinery responsible for the generation and transport of loaded MHC molecules. For instance, TAP and tapasin are common targets of viral proteins.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

95 entries grouped by protein

reorder by strain

1 entry

Anti-CRISPR protein 30 (Gene product 30) (gp30)

1 entry

Anti-CRISPR protein 31 (ACR3112-31) (Gene product 31) (gp31)

1 entry

G-protein coupled receptor BILF1 (GPCR BILF1)

3 entries

Protein BNLF2a

BNL2A_EBVA8

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

BNL2A_EBVB9

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

BNL2A_EBVG

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

1 entry

CD2 homolog (CD2H) (5HL) (CD2v) (T-lymphocyte CD2 receptor-like protein) (CD2-like protein) (pEP402R)

7 entries

Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)

E3GL_ADE02

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E3GL_ADE05

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

E3GL_ADE03

Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3)

Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (Early E3 19.2 kDa glycoprotein) (GP19K)

E3GL_ADE06

Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)

4E5X

E3GL_ADE1A

Human adenovirus B serotype 11 (strain BC34) (HAdV-11) (Human adenovirus 11A (strain BC34))

E3GL_ADE1P

Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))

E3GL_ADE35

Human adenovirus B serotype 35 (HAdV-35) (Human adenovirus 35)

1 entry

DNA alpha-glucosyltransferase (AGT) (Alpha-GT) (EC 2.4.1.26)

5 entries

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

ICP47_CHV1E

Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus) reference strain

ICP47_HHV11

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

1QLO

ICP47_HHV2H

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

ICP47_CHV16

Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2)

ICP47_HSV2S

Herpes simplex virus type 2 (strain SA8) (Simian agent 8)

6 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

LAP_MYXVL

Myxoma virus (strain Lausanne) (MYXV) reference strain

LAP_RFVKA

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

LAP_YMTV5

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase)

LAP_LSDV

Lumpy skin disease virus (LSDV)

LAP_SWPVK

Swinepox virus (strain Kasza) (SWPV)

LAP_YLDV

Yaba-like disease virus (YLDV)

1 entry

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (MK3) (Modulator of immune recognition 1 homolog) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

45 entries

Protein Nef (3'ORF) (Negative factor) (F-protein)

NEF_HV190

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

NEF_HV192

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

NEF_HV193

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

NEF_HV1A2

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

3RBB; 3REA; 3REB; 4ORZ; 4U1K; 4U1L; 4U1M; 4U1N; 4U5W; 5XOV; 6B72; 7D7S; 8F2P

NEF_HV1AN

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

3WLB

NEF_HV1B9

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain

NEF_HV1BR

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

1AVV; 1AVZ; 1EFN; 4D8D; 6URI

NEF_HV1EL

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

NEF_HV1ET

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

NEF_HV1H2

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

3RL2; 4NEE; 4WU5; 4WU7; 5HGA; 5HGB; 5HGD; 5HGH; 7K80; 7K81; 7YG3; 8GVB; 8GVG; 8GVI; 9BL9; 9BLA

NEF_HV1MA

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

3W0W; 3WL9

NEF_HV1MN

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

NEF_HV1RH

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain

NEF_HV1U4

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1) reference strain

NEF_HV1VI

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

NEF_HV1YF

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

NEF_SIVCZ

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVEK

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVMB

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_HV112

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

1QA4; 1QA5; 1ZEC

NEF_HV196

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

NEF_HV197

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

NEF_HV19N

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

NEF_HV1B1

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

1ZEC; 3TB8

NEF_HV1B8

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

NEF_HV1BN

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

NEF_HV1H3

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

NEF_HV1JR

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

NEF_HV1LW

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

2NEF

NEF_HV1M2

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

NEF_HV1MP

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

NEF_HV1MV

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

NEF_HV1ND

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

NEF_HV1OY

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

NEF_HV1S1

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

NEF_HV1S2

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

NEF_HV1S3

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

NEF_HV1S9

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

NEF_HV1SC

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

NEF_HV1SE

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

NEF_HV1V9

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

NEF_HV1Y2

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

NEF_HV1YB

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

NEF_HV1Z6

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

1QVO

NEF_HV1ZH

Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)

7 entries

Non-structural protein 1 (Non-structural protein 1C)

NS1_BRSVA

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

NS1_HRSVB

Human respiratory syncytial virus B (strain B1) reference strain

NS1_HRSS2

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_HRSV

Human respiratory syncytial virus

NS1_HRSV1

Human respiratory syncytial virus B (strain 18537)

NS1_HRSVA

Human respiratory syncytial virus A (strain A2)

Non-structural protein 1 (NS1) (Non-structural protein 1C)

NS1_ORSVW

Ovine respiratory syncytial virus (strain WSU 83-1578) (ORSV)

1 entry

ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4)

2 entries

Accessory protein p12I

P12I_HTL1A

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain

P12I_HTL1C

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

3 entries

Protein OPG163

PG163_MONPV

Monkeypox virus reference strain

PG163_VACCC

Vaccinia virus (strain Copenhagen) (VACV) reference strain

PG163_VACCW

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

2 entries

Protein OPG173

PG173_MONPV

Monkeypox virus reference strain

PG173_VACCW

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

1 entry

Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)

3 entries

Unique short US6 glycoprotein

US06_HCMVA

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US6 glycoprotein (Protein HXLF6) (gpUS6)

US06_HCMVM

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

US06_HCMVT

Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

Unique short US6 glycoprotein (HXLF6) (gpUS6)

2 entries

Membrane glycoprotein US11

US11_HCMVA

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)

8FRT; 8FU4

US11_HCMVM

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

1 entry

Probable protein E5

1 entry

Inhibition of host adaptive immune response by virus (kw:KW-1080)

Matching UniProtKB/Swiss-Prot entries

Anti-CRISPR protein 30 (Gene product 30) (gp30)

Anti-CRISPR protein 31 (ACR3112-31) (Gene product 31) (gp31)

G-protein coupled receptor BILF1 (GPCR BILF1)

Protein BNLF2a

CD2 homolog (CD2H) (5HL) (CD2v) (T-lymphocyte CD2 receptor-like protein) (CD2-like protein) (pEP402R)

Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)

DNA alpha-glucosyltransferase (AGT) (Alpha-GT) (EC 2.4.1.26)

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (MK3) (Modulator of immune recognition 1 homolog) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

Protein Nef (3'ORF) (Negative factor) (F-protein)

Non-structural protein 1 (Non-structural protein 1C)

ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4)

Accessory protein p12I

Protein OPG163

Protein OPG173

Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)

Unique short US6 glycoprotein

Membrane glycoprotein US11

Probable protein E5

Viral IRF3-like protein (VIRF-3)