Orthopneumovirus

VIRION

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Enveloped, spherical. Diameter from about 150nm nm.

GENOME

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Negative-stranded RNA linear genome, about 15 kb in size. Encodes for 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by strain (browse by keywords)

11 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
SH_BRSVA Small hydrophobic protein (Small protein 1A)
M21_BRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
PHOSP_BRSVA Phosphoprotein (Protein P)
MATRX_BRSVA Matrix protein (M protein)
FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
GLYC_BRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
L_BRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M22_BRSVA Protein M2-2
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)

11 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
SH_HRSVA Small hydrophobic protein (Small protein 1A)
PHOSP_HRSVA Phosphoprotein (Protein P)
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
M21_HRSVA Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1) (Vp24)
NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
GLYC_HRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_HRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
MATRX_HRSVA Matrix protein (M protein)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
M22_HRSVA Protein M2-2
L_HRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

11 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
L_HRSVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_HRSVB Phosphoprotein (Protein P)
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
MATRX_HRSVB Matrix protein (M protein)
SH_HRSVB Small hydrophobic protein (Small protein 1A)
GLYC_HRSVB Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening ...
NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)
M21_HRSVB Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
M22_HRSVB Protein M2-2

8 entries

Murine pneumonia virus (strain 15) (MPV) reference strain

Select_allDeselect_all
PHOSP_MPV15 Phosphoprotein (Protein P)
NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)
L_MPV15 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M21_MPV15 Protein M2-1 (Envelope-associated 22 kDa protein) (Transcription antitermination factor M2-1)
FUS_MPV15 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_MPV15 Matrix protein (M protein)
NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)
NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

7 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
PHOSP_HRSV1 Phosphoprotein (Protein P)
SH_HRSV1 Small hydrophobic protein (Small protein 1A)
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
GLYC_HRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_HRSV1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)
NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)

6 entries

Human respiratory syncytial virus A (strain Long)

Select_allDeselect_all
PHOSP_HRSVL Phosphoprotein (Protein P)
GLYC_HRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_HRSVL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...
NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
L_HRSVL RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

3 entries

Bovine respiratory syncytial virus (strain Rb94) (BRS)

Select_allDeselect_all
NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)
GLYC_BRSVR Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_BRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

3 entries

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Select_allDeselect_all
SH_HRSS2 Small hydrophobic protein (Small protein 1A)
MATRX_HRSS2 Matrix protein (M protein)
NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)

2 entries

Bovine respiratory syncytial virus (strain 391-2) (BRS)

Select_allDeselect_all
SH_BRSV3 Small hydrophobic protein (Small protein 1A)
NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

2 entries

Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

Select_allDeselect_all
GLYC_BRSVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...
FUS_BRSVC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

2 entries

Human respiratory syncytial virus B (strain 8/60)

Select_allDeselect_all
SH_HRSV8 Small hydrophobic protein (Small protein 1A)
GLYC_HRSV8 Major surface glycoprotein G (Attachment glycoprotein G) [Cleaved into: Mature secreted glycoprotein ...

1 entry

Bovine respiratory syncytial virus (strain 127) (BRS)

GLYC_BRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 220-60) (BRS)

GLYC_BRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 220-69) (BRS)

GLYC_BRSV9 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 375) (BRS)

GLYC_BRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain 4642) (BRS)

GLYC_BRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Lelystad) (BRS)

GLYC_BRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Snook) (BRS)

GLYC_BRSVS Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Bovine respiratory syncytial virus (strain Wbh) (BRS)

GLYC_BRSVW Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus

PHOSP_HRSV Phosphoprotein (Protein P)

1 entry

Human respiratory syncytial virus A (strain RSS-2)

FUS_HRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2 (F2); p27 (Intervening segment) (Pep27) ...

1 entry

Human respiratory syncytial virus A (strain rsb1734)

GLYC_HRSV3 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb5857)

GLYC_HRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6190)

GLYC_HRSV5 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6256)

GLYC_HRSV6 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb642)

GLYC_HRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...

1 entry

Human respiratory syncytial virus A (strain rsb6614)

GLYC_HRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved ...