Orthopneumovirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

82 entries grouped by strain (browse by keywords)

All proteins are shown (view only 44 complete proteome entries)

11 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
M21_HRSVA Matrix M2-1 (Envelope-associated 22 kDa protein)
PHOSP_HRSVA Phosphoprotein (Protein P)
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
L_HRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYC_HRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
FUS_HRSVA Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; ...
M22_HRSVA Matrix M2-2
SH_HRSVA Small hydrophobic protein (Small protein 1A)
MATRX_HRSVA Matrix protein

11 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
L_HRSVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M22_HRSVB Matrix M2-2
FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; ...
MATRX_HRSVB Matrix protein
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)
NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)
M21_HRSVB Matrix M2-1 (Envelope-associated 22 kDa protein)
GLYC_HRSVB Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
PHOSP_HRSVB Phosphoprotein (Protein P)
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
SH_HRSVB Small hydrophobic protein (Small protein 1A)

4 entries

Murine pneumonia virus (strain 15) (MPV) reference strain

Select_allDeselect_all
L_MPV15 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_MPV15 Phosphoprotein (Protein P)
M21_MPV15 Matrix M2-1 (Envelope-associated 22 kDa protein)
MTRX_MPV15 Matrix protein

11 entries

Bovine respiratory syncytial virus (strain A51908) (BRS)

Select_allDeselect_all
GLYC_BRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
M22_BRSVA Matrix M2-2
MATRX_BRSVA Matrix protein
L_BRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
M21_BRSVA Matrix M2-1 (Envelope-associated 22 kDa protein)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
PHOSP_BRSVA Phosphoprotein (Protein P)
SH_BRSVA Small hydrophobic protein (Small protein 1A)
FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...

4 entries

Murine pneumonia virus (strain 15) (MPV)

Select_allDeselect_all
FUS_MPV15 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)
NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)

7 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
GLYC_HRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)
NS1_HRSV1 Non-structural protein 1 (Non-structural protein 1C)
PHOSP_HRSV1 Phosphoprotein (Protein P)
FUS_HRSV1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...
SH_HRSV1 Small hydrophobic protein (Small protein 1A)
NS2_HRSV1 Non-structural protein 2 (NS2) (Non-structural protein 1B)

6 entries

Human respiratory syncytial virus A (strain Long)

Select_allDeselect_all
FUS_HRSVL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...
PHOSP_HRSVL Phosphoprotein (Protein P)
L_HRSVL RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
GLYC_HRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
NS2_HRSVL Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_HRSVL Non-structural protein 1 (Non-structural protein 1C)

3 entries

Bovine respiratory syncytial virus (strain Rb94) (BRS)

Select_allDeselect_all
FUS_BRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...
NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)
GLYC_BRSVR Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

3 entries

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Select_allDeselect_all
NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)
MATRX_HRSS2 Matrix protein
SH_HRSS2 Small hydrophobic protein (Small protein 1A)

2 entries

Bovine respiratory syncytial virus (strain 391-2) (BRS)

Select_allDeselect_all
NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)
SH_BRSV3 Small hydrophobic protein (Small protein 1A)

2 entries

Bovine respiratory syncytial virus (strain Copenhagen) (BRS)

Select_allDeselect_all
GLYC_BRSVC Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
FUS_BRSVC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...

2 entries

Human respiratory syncytial virus B (strain 8/60)

Select_allDeselect_all
GLYC_HRSV8 Major surface glycoprotein G (Attachment glycoprotein G)
SH_HRSV8 Small hydrophobic protein (Small protein 1A)

1 entry

Bovine respiratory syncytial virus (strain 127) (BRS)

GLYC_BRSV1 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain 220-60) (BRS)

GLYC_BRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain 220-69) (BRS)

GLYC_BRSV9 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain 375) (BRS)

GLYC_BRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain 4642) (BRS)

GLYC_BRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain Lelystad) (BRS)

GLYC_BRSVL Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain Snook) (BRS)

GLYC_BRSVS Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Bovine respiratory syncytial virus (strain Wbh) (BRS)

GLYC_BRSVW Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus

PHOSP_HRSV Phosphoprotein (Protein P)

1 entry

Human respiratory syncytial virus A (strain RSS-2)

FUS_HRSVR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...

1 entry

Human respiratory syncytial virus A (strain rsb1734)

GLYC_HRSV3 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus A (strain rsb5857)

GLYC_HRSV4 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus A (strain rsb6190)

GLYC_HRSV5 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus A (strain rsb6256)

GLYC_HRSV6 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus A (strain rsb642)

GLYC_HRSV2 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

1 entry

Human respiratory syncytial virus A (strain rsb6614)

GLYC_HRSV7 Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)