Orthopneumovirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for 11 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The NS2 protein plays a role in inhibition of RIG-I antiviral signaling

The NS1 protein plays a role in inhibition of MAVS antiviral signaling

Activation of host NF-kappa-B

The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.

Matching UniProtKB/Swiss-Prot entries

44 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 82 entries)

11 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

Select_allDeselect_all
M22_BRSVA Matrix M2-2
L_BRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M21_BRSVA Matrix M2-1 (Envelope-associated 22 kDa protein)
MATRX_BRSVA Matrix protein
FUS_BRSVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; Fusion ...
PHOSP_BRSVA Phosphoprotein (Protein P)
SH_BRSVA Small hydrophobic protein (Small protein 1A)
NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
NS2_BRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
NS1_BRSVA Non-structural protein 1 (Non-structural protein 1C)
GLYC_BRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

11 entries

Human respiratory syncytial virus A (strain A2) reference strain

Select_allDeselect_all
GLYC_HRSVA Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
MATRX_HRSVA Matrix protein
L_HRSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
M22_HRSVA Matrix M2-2
M21_HRSVA Matrix M2-1 (Envelope-associated 22 kDa protein)
NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
SH_HRSVA Small hydrophobic protein (Small protein 1A)
PHOSP_HRSVA Phosphoprotein (Protein P)
NS1_HRSVA Non-structural protein 1 (NS1) (Non-structural protein 1C)
NS2_HRSVA Non-structural protein 2 (NS2) (Non-structural protein 1B)
FUS_HRSVA Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; ...

11 entries

Human respiratory syncytial virus B (strain B1) reference strain

Select_allDeselect_all
GLYC_HRSVB Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
L_HRSVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_HRSVB Phosphoprotein (Protein P)
MATRX_HRSVB Matrix protein
M21_HRSVB Matrix M2-1 (Envelope-associated 22 kDa protein)
NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)
NS2_HRSVB Non-structural protein 2 (NS2) (Non-structural protein 1B)
SH_HRSVB Small hydrophobic protein (Small protein 1A)
M22_HRSVB Matrix M2-2
NS1_HRSVB Non-structural protein 1 (Non-structural protein 1C)
FUS_HRSVB Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2'; Interchain peptide; ...

8 entries

Murine pneumonia virus (strain 15) (MPV) reference strain

Select_allDeselect_all
M21_MPV15 Matrix M2-1 (Envelope-associated 22 kDa protein)
PHOSP_MPV15 Phosphoprotein (Protein P)
MTRX_MPV15 Matrix protein
L_MPV15 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NS1_MPV15 Non-structural protein 1 (Non-structural protein 1C)
NS2_MPV15 Non-structural protein 2 (NS2) (Non-structural protein 1B)
NCAP_MPV15 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_MPV15 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

3 entries

Human respiratory syncytial virus A (strain S-2) (HRSV-S2)

Select_allDeselect_all
MATRX_HRSS2 Matrix protein
NS1_HRSS2 Non-structural protein 1 (NS1) (Non-structural protein 1C)
SH_HRSS2 Small hydrophobic protein (Small protein 1A)