Isavirus (taxid:324913)

VIRION

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Enveloped. Usually rounded but can be filamentous. The virions are 90-130 nm in diameter.

GENOME

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segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 8 segments coding for at least 8 proteins. Segments size range from 0.8 to 2.2 kb. Genome total size is about 13.5 Kb.

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 7 mRNA can be alternatively spliced, giving rise to mRNA coding for P6 and P7 proteins.

ENZYMES

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HA protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

10 entries grouped by protein

1 entry

Fusion glycoprotein F0 (Protein 3) (P3)

FUS_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Hemagglutinin-esterase (HE) (EC 3.1.1.53) (gp42)

HEMA_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Matrix protein 1 (M1) (Protein P6) (P6) (vp22)

M1_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) (vp66)

NCAP_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Nuclear export protein (NEP) (Protein P5) (P5)

NEP_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Non-structural protein 1 (NS1) (Protein P4) (P4)

NS1_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Protein P7 (P7)

P7_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Polymerase acidic protein (PA) (Protein 2) (P2) (RNA-directed RNA polymerase subunit P2)

PA_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

Polymerase basic protein 2 (PB2) (Protein 3) (P3) (RNA-directed RNA polymerase subunit P3)

PB2_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain

1 entry

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (Protein 1) (P1) (RNA-directed RNA polymerase subunit P1)

RDRP_ISAV8
Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) (ISAV) reference strain