image Last update: 8 June 2022

The table below provides a non-exhaustive list of known host-vacciniavirus interactions, and with the Monkexpox reference sequence homologs. This list is not exhaustive, and will be updated. Genes are named according to Universal nomenclature (UN), Vaccinia virus strain Copenhagen nomenclature and Monkeypox (MPV) nomenclature .

GeneVacinia- Cop
gene
Monkeypox
gene
Vaccinia proteinMonkeypox homologViral protein nameHost proteins

FUNCTION: ENTRY
OPG095L1RM1RP07612Q5IXU5Protein L1May bind a host entry receptor
OPG120D8LE8LP04195A0A0F6N859Cell surface-binding proteinGlycan chondroitin sulfate
OPG108H3LH3LP07240A0A0F6N9X0Envelope protein H3Heparan sulfate

FUNCTION: EXIT
OPG164A36RA38RP68619A0A0F6N7S2IEV transmembrane phosphoproteinNCK1 KLC1 ITSN1 and EPS15
OPG062F17RC23RP07396Q5IXX6Phosphoprotein F17RICTOR and RPTOR
OPG056F12LC18LQ80HX6A0A2L0AQR3Protein F12KLC2

FUNCTION: HOST IMMUNE MODULATION

image

GeneVacinia- Cop
gene
Monkeypox
gene
Vaccinia proteinMonkeypox homologViral protein nameHost proteins
OPG001C23LJ3RQ805H7Q6WYZ8Chemokine binding protein
OPG002C22LJ2LQ76ZJ3O57102TNF receptor (CrmB) TNF, LTA, CCL28, CCL25, CXCL12, CXCL13 and CXCl14
OPG025C9LD9L P17372A0A0F6N8R3 IFN evasion proteinSCF complex (CUL1)
OPG065E3LF3LP21605Q5IXX3RNA-binding protein E3ISG15 EIF2AK2/PKR ZBP1 .
OPG106H1LH1LP07239Q5IXT4Dual specificity protein phosphatase H1 STAT1 dephosphorylation
OPG019C11RD3RP01136A0A0F6N8I4Viral epidermal growth factorEGFR
OPG029C6LD11LP17362Q3T6C8Protein C6TANK, TBKBP1 AND AZI2 , STAT2
OPG045F1LC7LP24356A0A0F6N8S5Protein F1BCL2L11, NLRP1 , BAK .
OPG204B19RB16RP25213A0A0F6NA19Soluble interferon alpha/beta receptorIFNalpha
OPG039K1LC1LP04297Q5IXZ7Interferon antagonist K1L?
OPG200C16LB13RP24772Q5IXK3Protein B13IKBKB
OPG193B8RB9RP24770A0A2L0AR39Soluble interferon gamma receptor B8IFNG
OPG035N1LP1LP17361Q5QC75Protein N1BAD and BAX
OPG044K7RC6RP68466Q3T781Protein K7DDX3
OPG163A35RA37RQ01232A0A0F6N9CMHC modulating protein?
OPG170A41LA41LP24766A0A2L0ARG9Protein A41Chemokines (CCL21, CCL25, CCL26 and CCL28)
OPG176A46RA47RP26672A0A2L0ARH6TLR inactivating proteinMYD88, TRAM
OPG188B2RQ01225A0A0F7G945Poxin, DNA sensing inhibitor2',3'-cGAMP degradation
OPG022D6LP17357A0A0F6N7E6Interleukin-18-binding proteinIl-18



Source: Uniprot.org