Inhibition of host TRAFs by virus (kw:KW-1110)

Several TRAF family members have been involved in the signaling pathway leading to the establishment of the antiviral state in the infected cells by viruses. For example, TRAF2 has been shown to be essential in RIG-I mediated expression of interferon upon Sendai virus infection in mouse fibroblasts. TRAF3 and TRAF6 are also key components of the signaling pathway downstream of MAVS.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB NS5a VP4 HDAG VFLIP gn LMP1 M

Therefore a lot of viruses encode proteins which target the TRAF protein family. NS5A from hepatitis C virus, rotavirus VP4, hepatitis delta virus LHDAg and SHDAg, as well as vFLIP from KSVH directly interact with TRAF2. These interactions modulate production of cytokines by infected cells.

The TRAF3 protein is also the target of many viral proteins. Hantavirus Gn, Severe acute respiratory syndrome coronavirus M, and herpes virus LMP1 interact with TRAF3 and interfere with the TRAF3 / TBK1 interaction required to activate IRF3 / IRF7.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Inhibition of MDA5/RIG-I pathway Inhibition of RIG-I
Inhibition of MDA5
Inhibition of MAVS
Inhibition of host TRAFs
Inhibition of host IRF3
Inhibition of host IRF7
Inhibition of host TBK1-IKBKE-DDX3 complex
Links Uniprot Keyword: KW-1110
GO ontology: GO:0039527
Virus -Epstein-Barr virus
(Herpesviridae, Lymphocryptovirus)

-NY-1 hantavirus
(Bunyaviridae, Hantavirus)

-Hepatitis C
(Flaviviridae, Hepacivirus)

-SARS-CoV
(Coronaviridae, Betacoronavirus)

-Kaposi's sarcoma herpesvirus
(Herpesviridae, Rhadinovirus)

-Vaccinia virus
(Poxviridae, Orthopoxvirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

58 entries grouped by protein

2 entries

Protein A52

Select_allDeselect_all
A52_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
A52_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

pdb 2VVW; 2VVX

18 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

pdb 5LJX; 5LJY; 5LJZ; 5LK0; 5LK1; 5LK2; 5LK3; 6Y6P

GP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81) reference strain
GP_ANDV
Andes orthohantavirus (ANDV) (Andes virus)

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

pdb 2K9H; 6Y5F; 6Y5W; 6Y6Q; 6YRB; 6YRQ; 6ZJM; 8DBZ

GP_BCCV
Black Creek Canal orthohantavirus (BCCV) (Black Creek Canal virus)

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

GP_DOBV
Dobrava-Belgrade orthohantavirus (DOBV) (Dobrava virus)

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

GP_HANTB
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
GP_HANTH
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
GP_HANTL
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
GP_NYV
New York virus (NYV)
GP_PHV
Prospect Hill virus (PHV)
GP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
GP_PUUMK
Puumala virus (strain K27)
GP_PUUMP
Puumala virus (strain P360)

pdb 5J81; 5J9H

GP_SEOU8
Seoul virus (strain 80-39)
GP_SEOUR
Seoul virus (strain R22)
GP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)
GP_SINV
Sin Nombre orthohantavirus (SNV) (Sin Nombre virus)
GP_TULV
Tula orthohantavirus (TULV) (Tula virus)

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

5 entries

Latent membrane protein 1 (LMP-1) (Protein p63)

Select_allDeselect_all
LMP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

pdb 1CZY

LMP1_EBVC
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

pdb 8XH6; 8XH7

LMP1_EBVR
Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

pdb 1ZMS

33 entries

Genome polyprotein

Select_allDeselect_all
POLG_HCV77
Hepatitis C virus genotype 1a (isolate H77) (HCV) reference strain

pdb 1A1R; 1A1V; 1CWX; 1HEI; 1JR6; 1N1L; 1ONB; 1R7C; 1R7D; 1R7E; 1R7F; 1R7G; 1RGQ; 2A4R; 2F9V; 2HD0; 2JXF; 2KDR; 2N1P; 2O8M; 2OBO; 2OBQ; 2OC0; 2OC1; 2OC7; 2OC8; 2OIN; 2P59; 2QV1; 2XI2; 2XI3; 2XNI; 3RC4; 3RC5; 4CL1; 4JZN; 4JZO; 4MWF; 4N0Y; 4Q0X; 4XVJ; 4Z0X; 5EOC; 5ERW; 5FGB; 5FGC; 5JZI; 5YXN; 5YXU; 6BQJ; 6BQK; 6BZU; 6BZV; 6BZW; 6BZY; 6UYD; 6WO5; 6WOQ; 7DUU

POLG_SVV1
Seneca Valley virus (isolate -/United States/SSV-001/2002) (SVV) reference strain

pdb 3CJI; 6ADL; 6CX1; 6L0T

POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)

pdb 1RTL; 2A4G; 2GVF; 3EYD; 3HKW; 3KN2; 3QGH; 3QGI; 3RC4; 3RC5; 3SU4; 6MVO; 6N4N; 6VDO; 7MM3; 7MM4; 7MM9; 7MMA; 7MMB; 7MMC; 7MMD; 7MME; 7MMK; 7MML

POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)

pdb 1ZH1; 2JY0; 2KWT; 2KWZ; 3FQL; 3FQM; 3FQQ; 3KN2; 3KQH; 3KQK; 3KQL; 3KQN; 3KQU; 3Q0Z; 3QGD; 3QGE; 3QGF; 3QGG; 4NLD; 4U01; 5E4F; 5PZK; 5PZL; 5PZM; 5PZN; 5PZO; 5PZP; 5TRH; 5TRI; 5TRJ; 5TRK; 5TWN

POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)

pdb 6P6Z

POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)

pdb 2M6X

POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)

pdb 2KNU; 3MRG; 3MRH; 3MRI; 3MRJ; 3MRL

POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)

pdb 1NB4; 1NB6; 1NB7; 2F55; 2MTS; 2XHU; 2XHV; 2XHW; 2YOJ; 3CSO; 3GNV; 3GNW; 3GOL; 3HKY; 3LKH; 3MWV; 3MWW; 3SKA; 3SKE; 3SKH; 3TYQ; 3TYV; 3U4O; 3U4R; 3UPH; 3UPI; 4DRU; 4EAW; 4GMC; 4IZ0; 4J02; 4J04; 4J06; 4J08; 4J0A; 4JJS; 4JJU; 4JTW; 4JTY; 4JTZ; 4JU1; 4JU2; 4JU3; 4JU4; 4JU6; 4JU7; 4JVQ; 4JY0; 4JY1; 4MZ4; 4OOW; 4RY4; 4RY5; 4RY6; 4RY7; 5CZB; 5NPH; 5NPI

POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)

pdb 1YUY; 1YV2; 1YVX; 1YVZ; 2XWH; 4ADP

POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)

pdb 1XCQ; 1XCT; 1XF5; 3GSZ; 3HVO

POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)

pdb 1DXP; 1DY8; 1DY9; 1W3C; 2K8J; 3OYP; 3P8N; 3P8O; 4A1T; 4A1V; 4A1X; 4I31; 4I32; 4I33; 4JMY; 4KTC

POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)

pdb 2KZQ; 2LIF; 2LVG; 2XXD; 2XYM; 3I5K; 4AEP; 4AEX; 4E76; 4E78; 4E7A; 4J1V; 4OBC; 4WT9; 4WTA; 4WTC; 4WTD; 4WTE; 4WTF; 4WTG; 4WTI; 4WTJ; 4WTK; 4WTL; 4WTM; 5NPJ; 5QJ0; 5QJ1; 5TWM; 5UJ2; 6HT4

POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)

pdb 6P6S

POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)

pdb 1N64; 2ZJO

POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)