Viral penetration via permeabilization of host membrane (kw:KW-1173)

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Some non-enveloped viruses induce local permeabilization of host endosomal membrane to allow virus capsid penetration into the cytoplasm. This is achieved through the interaction between the host membrane and a membrane-penetration protein associated with the capsid.

Viral membrane-penetration protein might require first to be activated, mostly through endosomal acidic pH or receptor binding to display its membrane penetrating activity.

Interestingly it has been shown for rotavirus that the proteins responsible for membrane permeabilization share common mechanisms with enveloped virus fusion proteins .

Prokaryotic dsRNA viruses also have a membrane-interacting component associated to their capsid. Virus entry causes depolarization of the host cell membrane. As for other dsRNA viruses, this membrane-interacting component might thus induce permeabilization of the cell membrane . .

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Links Uniprot Keyword: KW-1173
GO ontology:GO:0140267
Virus Reoviridae
Rotavirus A
Bluetongue virus
Mammalian reoviruses
Nodaviridae
Flock house virus
Parvoviridae
Cystoviridae

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

120 entries grouped by protein

29 entries

Capsid protein VP1 (Coat protein VP1)

Select_allDeselect_all
CAPSD_AADNV
Aedes albopictus densovirus (isolate Boublik/1994) (AalDNV) reference strain

Capsid protein VP1/VP2 (Coat protein VP1/VP2)

CAPSD_AAV2S
Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Capsid protein VP1

CAPSD_ADVG
Aleutian mink disease parvovirus (strain G) (ADV) reference strain

Capsid protein VP1

CAPSD_JDNVP
Junonia coenia densovirus (isolate pBRJ/1990) (JcDNV) reference strain

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_MUMIP
Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain MVM(p))) reference strain
CAPSD_NODAM
Nodamura virus (strain Mag115) (NoV) reference strain

Capsid protein alpha (EC 3.4.23.44)

CAPSD_PAVBP
Bovine parvovirus 1 (BPV-1) reference strain

Minor capsid protein VP1 (EC 3.1.1.4)

CAPSD_PAVHV
Human parvovirus B19 (strain HV) (HPV B19) reference strain

Minor capsid protein VP1 (EC 3.1.1.4) (Coat protein VP1)

CAPSD_AEDEV
Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus)

Capsid protein VP1/VP2 (Coat protein VP1/VP2)

CAPSD_BOOLV
Boolarra virus (BoV)

Capsid protein alpha (EC 3.4.23.44)

CAPSD_DSDNV
Diatraea saccharalis densovirus (DsDNV)

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_FHV
Flock house virus (FHV)

Capsid protein alpha (EC 3.4.23.44)

CAPSD_FPV
Feline panleukopenia virus (FPV)
CAPSD_FPV19
Feline panleukopenia virus (strain 193) (FPV)
CAPSD_GMDNV
Galleria mellonella densovirus (GmDNV)

Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

CAPSD_MEVA
Mink enteritis virus (strain Abashiri) (MEV)
CAPSD_MUMIM
Murine minute virus (strain MVMi) (MVM) (Murine parvovirus)
CAPSD_PAV
Pariacoto virus (PaV)

Capsid protein alpha (EC 3.4.23.44)

CAPSD_PAVC
Canine parvovirus type 2 (CPV-2)

Capsid protein VP2 (Coat protein VP2)

CAPSD_PAVC7
Canine parvovirus type 2 (strain Dog/United States/780929/-) (CPV-2)
CAPSD_PAVCB
Canine parvovirus type 2 (isolate Dog/United States/CPV-b/1978) (CPV-2)
CAPSD_PAVCD
Canine parvovirustype 2 (isolate Dog/United States/CPV-d/1988) (CPV-2)
CAPSD_PAVCN
Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)
CAPSD_PAVHH
Hamster parvovirus H1
CAPSD_PAVHU
Human parvovirus B19 (isolate AU) (HPV B19)

Minor capsid protein VP1 (EC 3.1.1.4) (Coat protein VP1)

CAPSD_PAVL3
Parvovirus LuIII
CAPSD_PAVP9
Porcine parvovirus (strain 90HS) (PPV)
CAPSD_PAVPK
Porcine parvovirus (strain Kresse) (PPV)
CAPSD_PAVPN
Porcine parvovirus (strain NADL-2) (PPV)

3 entries

Outer capsid protein mu-1 (Mu1)

Select_allDeselect_all
MU1_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
MU1_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
MU1_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

1 entry

Protein Rep68 (EC 3.6.4.12)

REP68_AAV2S
Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

5 entries

Minor capsid protein VP2 (Minor structural protein VP2)

Select_allDeselect_all
VP2_POVJC
JC polyomavirus (JCPyV) (JCV) reference strain
VP2_SV40
Simian virus 40 (SV40) reference strain
VP2_POVBA
BK polyomavirus (strain AS) (BKPyV)
VP2_POVBK
BK polyomavirus (BKPyV) (Human polyomavirus 1)
VP2_POVS1
Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

70 entries

Outer capsid protein VP4 (Hemagglutinin)

Select_allDeselect_all
VP4_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Outer capsid protein VP4

VP4_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Outer capsid protein VP4

VP4_ROTB2
Rotavirus X (isolate RVX/Human/Bangladesh/NADRV-B219/2002/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-B219)) reference strain
VP4_ROTHC
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
VP4_ROTJ1
Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N) (Rotavirus (isolate novel adult diarrhea rotavirus-J19)) reference strain
VP4_ROTS1
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both)) reference strain
VP4_ROTSH
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
VP4_ROT18
Rotavirus A (isolate RVA/Cow/India/Hg18/2000/G15P[21]) (RV-A)
VP4_ROT41
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
VP4_ROT46
Rotavirus A (isolate RVA/Pig/Venezuela/A46/1985/G5P13[13]) (RV-A)
VP4_ROTAD
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
VP4_ROTAP
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
VP4_ROTB4
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
VP4_ROTB5
Rotavirus A (isolate RVA/Cow/Thailand/A5/1988/G8P6[1]) (RV-A)
VP4_ROTB6
Rotavirus A (isolate RVA/Cow/Thailand/61A/1988/G10P7[5]) (RV-A)
VP4_ROTB9
Rotavirus A (isolate RVA/Cow/Germany/993/1983/G18P[17]) (RV-A)
VP4_ROTBA
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
VP4_ROTBB
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11]) (RV-A)
VP4_ROTBC
Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1]) (RV-A)
VP4_ROTBK
Rotavirus A (isolate RVA/Cow/Japan/KK3/1983/G10P8[11]) (RV-A)
VP4_ROTBN
Rotavirus A (strain RVA/Cow/United States/NCDV-Lincoln/1969/G6P6[1]) (RV-A) (Rotavirus A (strain Nebraska calf diarrhea virus))
VP4_ROTBS
Rotavirus C (isolate RVC/Cow/Japan/Shintoku/1991/G2P[3]) (RV-C)
VP4_ROTBU
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
VP4_ROTBV
Rotavirus A (isolate RVA/Cow/United States/VMRI/1988/G6P[5]) (RV-A)
VP4_ROTCU
Rotavirus A (isolate RVA/Dog/United States/Cu-1/1982/G3P5A[3]) (RV-A)
VP4_ROTD9
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
VP4_ROTE1
Rotavirus A (strain RVA/Equine/United States/FI-14/1980/G3P4[12]) (RV-A) (Rotavirus A (strain FI14))
VP4_ROTEH
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
VP4_ROTEL
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
VP4_ROTEO
Rotavirus A (isolate RVA/Equine/Japan/HO-5/1980/G3P[X]) (RV-A)
VP4_ROTF1
Rotavirus A (isolate RVA/Cat/Japan/FRV-1/1986/G3P3[9]) (RV-A) (Rotavirus A (isolate FRV1))
VP4_ROTF6
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
VP4_ROTGA
Rotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B (isolate adult diarrhea rotavirus))
VP4_ROTGI
Rotavirus B (isolate RVB/Rat/United States/IDIR/1984/G1P[X]) (RV-B) (Rotavirus B (isolate infectious diarrhea of infant rats))
VP4_ROTH1
Rotavirus A (isolate RVA/Human/Sweden/1076/1983/G2P2A[6]) (RV-A)
VP4_ROTH3
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
VP4_ROTH5
Rotavirus A (strain RVA/Human/Australia/RV-5/1981/G2P1B[4]) (RV-A) (Rotavirus A (strain RV5))
VP4_ROTH6
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
VP4_ROTH7
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
VP4_ROTHD
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
VP4_ROTHJ
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
VP4_ROTHK
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
VP4_ROTHL
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
VP4_ROTHM
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
VP4_ROTHN
Rotavirus A (isolate RVA/Human/Australia/McN13/1980/G3P2A[6]) (RV-A)
VP4_ROTHO
Rotavirus A (strain RVA/Human/Japan/MO/1982/G3P1A[8]) (RV-A)
VP4_ROTHP
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
VP4_ROTHQ
Rotavirus A (isolate RVA/Human/Thailand/Mc35/1992/G10P11[14]) (RV-A)
VP4_ROTHT
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
VP4_ROTHU
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
VP4_ROTHV
Rotavirus A (isolate RVA/Human/Italy/VA70/1975/G4P1A[8]) (RV-A)
VP4_ROTHW
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
VP4_ROTHY
Rotavirus A (isolate RVA/Human/Israel/RO1845/1993/G3P5A[3]) (RV-A)
VP4_ROTMB
Rotavirus A (isolate RVA/Mouse/United States/Eb/1982/G16P10[16]) (RV-A)
VP4_ROTME
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
VP4_ROTP3
Rotavirus A (isolate RVA/Pig/Australia/CRW-8/1987/G3P9[7]) (RV-A)
VP4_ROTP5
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
VP4_ROTPC
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
VP4_ROTPG
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
VP4_ROTPY
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
VP4_ROTRA
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
VP4_ROTRF
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
VP4_ROTRH
Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A)
VP4_ROTS4
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
VP4_ROTSF
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
VP4_ROTSS
Rotavirus A (strain RVA/SA11-SEM/G3P5B[2]) (RV-A) (Simian Agent 11 (strain SEM))
VP4_ROTTU
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
VP4_ROTW3
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
VP4_ROTWI
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)
VP4_ROTYO
Rotavirus A (strain RVA/Human/Japan/YO/1977/G3P1A[8]) (RV-A)

12 entries

Outer capsid protein VP5

Select_allDeselect_all
VP5_BTV10
Bluetongue virus 10 (isolate USA) (BTV 10) reference strain
VP5_AHSV4
African horse sickness virus 4 (AHSV-4)
VP5_AHSV6
African horse sickness virus 6 (AHSV-6)
VP5_AHSV9
African horse sickness virus 9 (AHSV-9)
VP5_BRD
Broadhaven virus (BRD)
VP5_BTV11
Bluetongue virus 11 (isolate USA) (BTV 11)
VP5_BTV13
Bluetongue virus 13 (isolate USA) (BTV 13)
VP5_BTV17
Bluetongue virus 17 (isolate USA) (BTV 17)
VP5_BTV1A
Bluetongue virus 1 (isolate Australia) (BTV 1)
VP5_BTV1S
Bluetongue virus 1 (isolate South Africa) (BTV 1)
VP5_BTV2A
Bluetongue virus 2 (isolate USA) (BTV 2)
VP5_EHDV1
Epizootic hemorrhagic disease virus 1 (EHDV-1)