Cucumovirus (taxid:12304)
VIRION

Non-enveloped, spherical virion about 29nm in diameter with T=3 icosahedral symmetry, composed of 180 coat proteins: 12 pentamers and 20 hexamers.
GENOME
Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 3' tRNA-like structure and a 5'cap.
GENE EXPRESSION
Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins. ORF2b encodes a viral suppressor of RNA silencing (VSR) and is expressed probably as a subgenomic RNA (sgRNA4A).
ENZYMES
REPLICATION
CYTOPLASMIC
- Virus penetrates into the host cell.
- Uncoating, and release of the viral genomic RNA into the cytoplasm.
- Expression of protein 1a and 2a to produce replication proteins.
- Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
- Subgenomic RNA4 is translated producing capsid proteins.
- Assembly of new virus particles.
- Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.
Host-virus interaction
Suppression of RNA silencing
Cucumovirus protein 2b acts as a suppressor of RNA silencing
.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)74 entries grouped by strain
5 entries
Cucumber mosaic virus (strain FNY) (CMV) reference strain
5 entries
Tomato aspermy virus (TAV) reference strain
5 entries
Cucumber mosaic virus (strain Q) (CMV)
4 entries
Cucumber mosaic virus (strain Ixora) (CMV)
4 entries
Cucumber mosaic virus (strain NT9) (CMV)
4 entries
Cucumber mosaic virus (strain Y) (CMV)
4 entries
Peanut stunt virus (strain J) (PSV)
3 entries
Cucumber mosaic virus (strain As) (CMV)
3 entries
Cucumber mosaic virus (strain Iizuka) (CMV)
3 entries
Cucumber mosaic virus (strain Kor) (CMV)
3 entries
Cucumber mosaic virus (strain O) (CMV)
2 entries
Cucumber mosaic virus (strain C7-2) (CMV)
2 entries
Cucumber mosaic virus (strain CS) (CMV)
2 entries
Cucumber mosaic virus (strain FT) (CMV)
2 entries
Cucumber mosaic virus (strain Kin) (CMV)
2 entries
Cucumber mosaic virus (strain M) (CMV)
2 entries
Cucumber mosaic virus (strain M48) (CMV)
2 entries
Cucumber mosaic virus (strain N) (CMV)
2 entries
Cucumber mosaic virus (strain Pepo) (CMV)
2 entries
Cucumber mosaic virus (strain S) (CMV)
2 entries
Cucumber mosaic virus (strain Trk7) (CMV)
1 entry
Cucumber mosaic virus (strain B) (CMV)
1 entry
Cucumber mosaic virus (strain Banana) (CMV)
1 entry
Cucumber mosaic virus (strain C) (CMV)
1 entry
Cucumber mosaic virus (strain DKRD) (CMV)
1 entry
Cucumber mosaic virus (strain E5) (CMV)
1 entry
Cucumber mosaic virus (strain FC) (CMV)
1 entry
Cucumber mosaic virus (strain I17F) (CMV)
1 entry
Cucumber mosaic virus (strain K) (CMV)
1 entry
Cucumber mosaic virus (strain MB-8) (CMV)
1 entry
Cucumber mosaic virus (strain P6) (CMV)
1 entry