SARS coronavirus 2 (SARS-CoV-2) proteome
This page provides pre-release access to the SARS Coronavirus 2 protein sequences in UniProt from the current public health emergency. The data will become part of a future UniProt release and may be subject to further changes.
COVID-19 UniProt resource
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PDB structures
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Swissmodel 3d 
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| Annotated UniProtKB protein entries: | notes |
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| P0DTC1 Replicase polyprotein 1a (pp1a) | Viral transcription/replication |
| P0DTD1 Replicase polyprotein 1ab (pp1ab) | Viral transcription/replication, ribosomal frameshift |
| P0DTC2 Spike glycoprotein (S) | Attachment and entry |
| P0DTC3 ORF3a protein (NS3a) | ESCRT-independent budding |
| P0DTF1 ORF3b protein | Unknown, host-virus modulation? |
| P0DTG1 ORF3c protein | Unknown, host-virus modulation? |
| P0DTG0 ORF3d protein | Unknown, host-virus modulation? |
| P0DTC4 Envelope small membrane protein (E) | ESCRT-independent budding |
| P0DTC5 Membrane protein (M) | Virion morphogenesis |
| P0DTC6 ORF6 protein | Disrupts interferon signaling by preventing nuclear import of proteins. |
| P0DTC7 ORF7a protein | Disrupts Tetherin (BST2) antiviral activity. |
| P0DTD8 ORF7b protein | Unknown, host-virus modulation? |
| P0DTC8 ORF8 protein | Viral Interleukin 17A  ,
Inhibition of host MHC class I
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| P0DTC9 Nucleoprotein (N) | Viral genome packaging |
| P0DTD2 ORF9b protein | Disrupts host RLR innate antiviral pathway |
| P0DTD3 ORF9c protein | Unknown, host-virus modulation? |
| A0A663DJA2 Hypothetical ORF10 protein | Presumably not expressed |