Asfarviridae (taxid:137992)
VIRION

- Hexons: Double jelly roll-fold major capsid protein [Ba71V-081]
- Pentons: Single jelly roll-fold [Ba71V-120]
GENOME
Linear, dsDNA genome of 170-190 kb. End sequences are complementary. Encodes for at least 150 ORF.
GENE EXPRESSION
ENZYMES
- DNA-directed DNA polymerase B [DNApolbeta]
- DNA-directed RNA polymerase [RBP1, RBP2, RBP3-11, RBP5, RBP6, RBP7, RBP10]
- Cell-type capping
- Poly(A) polymerase [Ba71V-067]
- Peptidase C48 [Ba71V-111]
- mRNA-decapping [Ba71V-102]
- Ubiquitin-conjugating enzyme E2 [UBC
- Trans-prenyltransferase [Ba71V-074]
- DNA ligase [LIG]
- Repair DNA polymerase X [Ba71V-097]
- Deoxyuridine 5'-triphosphate nucleotidohydrolase [Ba71V-131]
- DNA topoisomerase 2 [TOP]
- Thymidylate kinase [TMK]
- Thymidine kinase [Ba71V-050]
- Ribonucleoside-diphosphate reductase [Small SU, Large SU]
- FAD-linked sulfhydryl oxidase [Ba71V-073]
- Helicase [Ba71V-072, Ba71V-123, Ba71V-040, primase]
REPLICATION
CYTOPLASMIC
- Attachment of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
- Fusion with the endocytic vesicle membrane occurs; DNA genome is released into the cytoplasm.
- Transcription of early viral genes; replication of the DNA genome in the cytoplasm begins about 6 hours post-infection.
- Following DNA replication, late viral genes are transcribed including structural proteins.
- Assembly of new virions occurs in cytoplasmic viral factories. Endoplasmic reticulum cisternae are recruited and transformed to give rise to precursor viral membranes, which represent the first identifiable viral structures. Viral membranes become icosahedral particles by the gradual assembly of the outer capsid layer formed by protein p72. At the same time, the matrix shell is formed underneath the viral envelope and the viral DNA and nucleoproteins are packaged and condensed.
- Virions migrate to plasma membrane on microtubules and bud.
Host-virus interaction
Apoptosis modulation
Several viral proteins from ASFV are dedicated to the modulation of apoptosis. For example, A224L prevent apoptosis of host cell by inhibiting caspase-3/CASP3 activation. Another viral protein, A179L, is a bcl-2 homolog and suppresses apoptosis.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)821 entries grouped by protein
4 entries
Protein MGF 100-1R
5 entries
Protein MGF 100-2L
5 entries
Protein MGF 100-3L
5 entries
Protein MGF 110-11L
2 entries
Protein MGF 110-12L
3 entries
Protein MGF 110-13L
3 entries
Protein MGF 110-14L
3 entries
Protein MGF 110-11L
6 entries
Protein MGF 110-1L
6 entries
Protein MGF 110-2L
1 entry
Protein MGF 110-3L
1 entry
Protein MGF 110-4L-B
7 entries
Protein MGF 110-4L
6 entries
Protein MGF 110-5L
6 entries
Protein MGF 110-6L
5 entries
Protein MGF 110-7L
4 entries
Protein MGF 110-8L
4 entries
Protein MGF 110-9L
1 entry
Uncharacterized membrane protein EP148R
5 entries
Protein MGF 300-1L
5 entries
Protein MGF 300-2R
1 entry
Protein MGF 300-3L
2 entries
Protein MGF 300-4L
4 entries
Protein MGF 360-10L
4 entries
Protein MGF 360-11L
4 entries
Protein MGF 360-12L
4 entries
Protein MGF 360-13L
4 entries
Protein MGF 360-14L
5 entries
Protein MGF 360-15R
5 entries
Protein MGF 360-16R
3 entries
Protein MGF 360-18R
4 entries
Protein MGF 360-19R
4 entries
Protein MGF 360-1L
1 entry
Protein MGF 360-20R
3 entries
Protein MGF 360-21R
1 entry
Protein MGF 360-22R
4 entries
Protein MGF 360-2L
5 entries
Protein MGF 360-3L
5 entries
Protein MGF 360-4L
3 entries
Protein MGF 360-5L
2 entries
Protein MGF 360-6L
1 entry
Protein MGF 360-7L
5 entries
Protein MGF 360-8L
5 entries
Protein MGF 360-9L
5 entries
Protein MGF 505-10R
5 entries
Protein MGF 505-11L
4 entries
Protein MGF 505-1R
5 entries
Protein MGF 505-2R
5 entries
Protein MGF 505-3R
5 entries
Protein MGF 505-4R
5 entries
Protein MGF 505-5R
2 entries
Protein MGF 505-6R
5 entries
Protein MGF 505-7R
5 entries
Protein MGF 505-9R
5 entries
Probable AP endonuclease (APE) (EC 3.1.21.-)
6 entries
Apoptosis regulator Bcl-2 homolog
2 entries
Uncharacterized protein C76L
4 entries
Hexon protein p72 (Major capsid protein) (MCP) (p72) (p73)
5 entries
Penton protein H240R (pH240R)
5 entries
CD2 homolog (CD2H) (5HL) (CD2v) (T-lymphocyte CD2 receptor-like protein) (CD2-like protein) (pEP402R)
5 entries
mRNA-decapping protein g5R (g5Rp) (EC 3.1.3.-) (ASFV-DP) (Diphosphoinositol polyphosphate phosphohydrolase) (DIPP) (EC 3.6.1.52)
5 entries
DNA ligase (EC 6.5.1.1) (Polydeoxyribonucleotide synthase
1 entry
Uncharacterized protein DP60R
5 entries
Protein DP71L (MyD116 homolog)
3 entries
TBK1 inhibitor DP96R
6 entries
DNA polymerase beta (EC 2.7.7.7)
5 entries
Repair DNA polymerase X (Pol X) (EC 2.7.7.7) (AsfvPolX)
5 entries
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
5 entries
Inner membrane protein pE248R (pE248R)
1 entry
Early transcription factor large subunit homolog (pG1340L) (VETFL homolog)
5 entries
Lectin-like protein EP153R (pEP153R)
3 entries
Early transcription factor large subunit homolog (VETFL homolog)
4 entries
Early transcription factor large subunit homolog (EC 3.6.4.13) (ATP-dependent helicase VETFS homolog)
1 entry
Putative membrane protein 162
1 entry
Putative membrane protein 164
1 entry
Putative membrane protein 165
1 entry
Envelope protein 166
1 entry
Envelope protein 167
1 entry
Envelope protein 168
1 entry
Envelope protein 169
4 entries
FAD-linked sulfhydryl oxidase (EC 1.8.3.2) (p14)
5 entries
Putative RNA Helicase B962L (EC 3.6.4.13)
5 entries
Putative primase C962R (EC 3.6.4.-)
5 entries
Transmembrane protein I329L
1 entry
Early protein I78R
11 entries
Inhibitor of apoptosis protein (IAP)
3 entries
IAP-like protein p27
5 entries
IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
1 entry
Uncharacterized protein J64R
5 entries
Thymidine kinase (TDK) (EC 2.7.1.21)
1 entry
Uncharacterized protein KP86R/DP86L
5 entries
Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)
1 entry
Uncharacterized protein L57L
5 entries
Protein L83L
5 entries
Minor capsid protein M1249L (pM1249L)
5 entries
mRNA-capping enzyme (VTF/CE)
5 entries
NifS-like protein
5 entries
Structural DNA-binding protein p10 (p10)
5 entries
Inner membrane protein p12 (Protein p12)
5 entries
Structural protein p14.5
5 entries
Minor capsid protein p17
5 entries
Inner membrane protein p22
6 entries
Phosphoprotein p30 (p30) (Phosphoprotein p32) (p32)
5 entries
Minor capsid protein p49 (p49)
6 entries
Inner membrane protein p54 (pE183L)
5 entries
Putative poly(A) polymerase catalytic subunit (EC 2.7.7.19)
5 entries
Serine/threonine-protein kinase 1 (EC 2.7.11.1)
1 entry
Uncharacterized protein pNG1
1 entry
Uncharacterized protein pNG2
1 entry
Uncharacterized membrane protein pNG3
1 entry
Uncharacterized membrane protein pNG4
1 entry
Uncharacterized protein pNG5
1 entry
Uncharacterized membrane protein pNG6
1 entry
Uncharacterized protein pNG7
5 entries
Polyprotein pp220 (220 kDa polyprotein)
5 entries
Polyprotein pp62 (60 kDa polyprotein) (p60) (62 kDa polyprotein) (p62)
5 entries
Putative helicase/primase complex protein (pF1055L)
5 entries
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase large subunit)
5 entries
Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small subunit)
2 entries
Putative RNA-ligase (pM448R)
5 entries
DNA-directed RNA polymerase RPB1 homolog (RPB1 homolog) (EC 2.7.7.6)
5 entries
DNA-directed RNA polymerase RPB10 homolog (RPB10 homolog)
5 entries
DNA-directed RNA polymerase RPB2 homolog (RPB2 homolog) (EC 2.7.7.6)
5 entries
DNA-directed RNA polymerase RPB3-11 homolog (RPB3-11 homolog)
5 entries
DNA-directed RNA polymerase RPB5 homolog (RPB5 homolog)
5 entries
DNA-directed RNA polymerase RPB6 homolog (RPB6 homolog)
5 entries
DNA-directed RNA polymerase RPB7 homolog (RPB7 homolog)
3 entries
DNA-directed RNA polymerase RPB9 homolog (RPB9 homolog)
5 entries
Putative TATA-binding protein pB263R (TBP)
4 entries
Initiation factor TFIIB homolog (pC315R)
5 entries
Transcription factor TFIIS homolog
4 entries
Termination factor NPH-I homolog (EC 3.6.4.-)
5 entries
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
5 entries
Trans-prenyltransferase (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranyltranstransferase) (EC 2.5.1.10) (Polyprenyl-diphosphate synthase)
5 entries
Ubiquitin-conjugating enzyme E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme) (UBCv1) (Ubiquitin carrier protein) (Ubiquitin-protein ligase) (pI215L)
5 entries
Inner membrane protein H108R (pH108R)
5 entries
Uncharacterized protein E111R (pE111R)
1 entry
Early transcription factor large subunit homolog (EC 3.6.4.13) (ATP-dependent helicase VETFS homolog)
5 entries
Uncharacterized protein B117L (pB117L)
1 entry
Uncharacterized protein A118R
2 entries
Uncharacterized protein C122R (pC122R)
5 entries
Uncharacterized protein CP123L (pCP123L)
5 entries
Uncharacterized protein H124R (pH124R)
5 entries
Uncharacterized protein B125R (pB125R)
5 entries
Uncharacterized protein C129R (pC129R) (EC 3.1.4.-)
1 entry
Early transcription factor large subunit homolog (Protein G1340L) (pG1340L) (VETFL homolog)
5 entries
Structural protein A137R
5 entries
Uncharacterized protein K145R (pK145R)
5 entries
Uncharacterized protein E146L (pE146L)
5 entries
Protein A151R (pA151R)
5 entries
Uncharacterized protein EP152R (pEP152R)
5 entries
Uncharacterized protein F165R (pF165R)
5 entries
Transmembrane protein B169L (pB169L)
5 entries
Uncharacterized protein H171R (pH171R)
5 entries
Uncharacterized protein B175L (pB175L)
5 entries
Protein I177L
5 entries
Uncharacterized protein S183L (pS183L)
5 entries
Uncharacterized protein E184L (pE184L)
5 entries
Late protein I196L
5 entries
Inner membrane protein E199L (pE199L)
5 entries
Uncharacterized protein K205R (pK205R)
5 entries
Late protein I226R (pI226R)
5 entries
Uncharacterized protein H233R (pH233R)
5 entries
Transmembrane protein C257L (pC257L)
5 entries
Protein I267L (pI267L)
5 entries
Uncharacterized protein E301R
5 entries
Uncharacterized protein CP312R (pCP312R)
1 entry
Uncharacterized protein C315R (pC315R)
5 entries
Uncharacterized protein F317L (pF317L)
1 entry
Transmembrane protein I329L
5 entries
Protein D345L (pD345L)
5 entries
Uncharacterized protein B354L (pB354L)
5 entries
ERCC4 domain-containing protein EP364R (pEP364R) (EC 3.1.4.-)
5 entries
Zinc finger protein B385R (pB385R)
5 entries
Uncharacterized protein B407L (pB407L)
5 entries
Uncharacterized protein K421R (pK421R)
5 entries
Uncharacterized protein E423R (pE423R)
5 entries
Probable methyltransferase EP424R (pEP424R) (EC 2.1.1.-)
3 entries
Putative RNA-ligase (pM448R)
5 entries
Uncharacterized protein B475L (pB475L)
5 entries
Putative ATP-dependent RNA helicase QP509L (EC 3.6.4.13)
5 entries
Protein B602L (pB602L)
5 entries
Uncharacterized protein C62L (pC62L)
5 entries
Uncharacterized protein DP63R
5 entries
Uncharacterized membrane protein X69R
1 entry
Termination factor NPH-I homolog (EC 3.6.4.-)
5 entries
Uncharacterized protein C717R (pC717R)
5 entries
Uncharacterized protein I73R
5 entries
Uncharacterized protein D79L (pD79L)
5 entries
Transmembrane protein EP84R (pEP84R)
5 entries
Uncharacterized protein C84L (pC84L)
5 entries
Probable helicase A859L (EC 3.6.4.-)
3 entries
Uncharacterized membrane protein KP93L
1 entry
Uncharacterized protein DP96R
5 entries
Transmembrane protein B66L (pB66L)
5 entries
Uncharacterized protein D129L (pD129L)
5 entries
Uncharacterized protein DP238L
3 entries
Host translation inhibitor E66L (pE66L)
5 entries
Protein H339R (pH339R) (Protein j4R)
5 entries
Viral histone-like protein (DNA-binding protein pA104R) (pA104R)
5 entries