Capripoxvirus (taxid:10265)
VIRION

Enveloped, brick-shaped , 300x270x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).
GENOME
Linear, dsDNA genome of about 154kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Sheeppox virus strain Agenome at
Poxvirus Bioinformatics Ressource center
GENE EXPRESSION
ENZYMES
- DNA dependent DNA polymerase
- DNA dependent RNA polymerase
- Cell-type capping
- RNA TPase
- GTase
- N7MTase
- 2'O methylase
- Core protease (Peptidase C57)
- Metalloprotease (Peptidase M44)
REPLICATION
CYTOPLASMIC
- Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core into the host cytoplasm.
- Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
- Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
- Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
- Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
- Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
- IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
Host-virus interaction
Apoptosis modulation
Capripoxvirus SPI-2 inhibits the proteolytic activity of interleukin 1- converting enzyme (ICE) and ICE-like enzymes.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)14 entries grouped by protein
2 entries
Envelope protein A28 homolog (Protein HM3)
1 entry
Protein B14 homolog (Protein T3A)
1 entry
Protein J1 homolog (Protein F7)
1 entry
Thymidine kinase (EC 2.7.1.21)
1 entry
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)
1 entry
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
1 entry
Putative fusion protein (Protein HM2)
2 entries
Probable host range protein 2
1 entry
G-protein coupled receptor homolog Q2/3L
1 entry
T3C protein
2 entries
T4 protein
Sheeppox virus taxid:10266
Sheeppox virus (strain InS-1) taxid:10268
Protein | ModelArchive |
Protein B14 homolog (Protein T3A) | ma-jd-viral-13479 |
Protein B14 homolog (Protein T3A) | ma-jd-viral-13481 |
Sheeppox virus (strain KS-1) taxid:10269
Protein | ModelArchive |
Envelope protein A28 homolog (Protein HM3) | ma-jd-viral-31661 |