Leporipoxvirus (taxid:10270)
VIRION

Enveloped, brick-shaped 300x250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).
GENOME
Linear, dsDNA genome of 160kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Myxoma virus strain Lausanne genome at Poxvirus Bioinformatics Ressource center
GENE EXPRESSION
ENZYMES
- DNA dependent DNA polymerase
- DNA dependent RNA polymerase
- Cell-type capping
- RNA TPase
- GTase
- N7MTase
- 2'O methylase
- Core protease (Peptidase C57)
- Metalloprotease (Peptidase M44)
REPLICATION
CYTOPLASMIC
- Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
- Fusion with the plasma membrane to release the core into the host cytoplasm.
- Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
- Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
- Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
- Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
- Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
- IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
Host-virus interaction
Adaptive immune response inhibition
The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules
.
Apoptosis modulation
Myxoma virus M11L inhibits host apoptosis by preventing the conformational activation of host Bax at the mitochondria .
Cell-cycle modulation
The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)60 entries grouped by protein
2 entries
Transcript termination protein A18 (EC 3.6.4.-)
3 entries
Envelope protein A28 homolog (MA28)
1 entry
Protein B14 homolog (Protein T3A)
1 entry
mRNA-decapping protein D10 (EC 3.1.3.-)
1 entry
Core protein D4
1 entry
Core protein D3 homolog (27 kDa virion core protein)
1 entry
mRNA-decapping protein D9 (EC 3.1.3.-)
1 entry
Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)
2 entries
Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)
2 entries
Early transcription factor 82 kDa subunit (ETF large subunit)
2 entries
Growth factor (Secreted epidermal growth factor-like)
3 entries
Thymidine kinase (EC 2.7.1.21)
2 entries
E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)
1 entry
Apoptosis regulator M11L
2 entries
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory subunit) (Poly(A) polymerase small subunit) (PAP-S) (VP39)
1 entry
mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large subunit)
1 entry
Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
2 entries
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II)
2 entries
Nucleoside triphosphatase I (EC 3.6.1.15) (M86L protein) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)
2 entries
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
2 entries
Probable metalloendopeptidase G1-type (EC 3.4.24.-)
2 entries
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
2 entries
DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
1 entry
Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)
2 entries
Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
1 entry
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
1 entry
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
3 entries
Probable host range protein 2-1
2 entries
Probable host range protein 2-2
2 entries
Probable host range protein 2-3
2 entries
MF7 protein
1 entry
Kelch repeat protein M-T8
1 entry
Kelch repeat protein M-T9 (M9-R polypeptide)
1 entry
Protein T1
2 entries
Tumor necrosis factor soluble receptor (Protein T2)
1 entry
T4 protein
1 entry