Molluscipoxvirus (taxid:10278)

VIRION

image

Enveloped, brick-shaped about 320x250x200nm. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 190kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Molluscum contagiosum virus strain subtype 1 genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Apoptosis modulation

Molluscipoxviruses encode a viral FLICE-inhibitory protein (v-FLIP) that prevents apoptosis induced by death receptors .

NF-kappa-B modulation

MC159 protein from the molluscum contagiosum inhibits NF-kappa-B activation by interacting with the IkB kinase complex .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

19 entries grouped by protein

1 entry

Envelope protein A28 homolog (Protein MC134)

A28_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)

CFLA_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)

ETF1_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Early transcription factor 82 kDa subunit (ETF large subunit)

ETF2_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

2 entries

Envelope protein F13 homolog (43 kDa protein) (p43K)

Select_allDeselect_all
F13_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain
F13_MCV2
Molluscum contagiosum virus subtype 2 (MOCV) (MCVII)

1 entry

Glutathione peroxidase (GPx) (GSHPx) (EC 1.11.1.9)

GPX_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Protein MC005

MC005_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Protein MC007

MC007_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Protein MC014

MC014_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Protein MC132

MC132_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Chemokine-like protein MC148

MC148_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Protein MC160

MC160_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Apoptosis regulator MC163R

MC163_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Probable metalloendopeptidase G1-type (EC 3.4.24.-)

MP44_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II)

NPH2_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

NTP1_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)

PAP1_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

1 entry

DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)

RP07_MCV1
Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Molluscum contagiosum virus subtype 1 taxid:10280

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-33583
25 kDa core protein OPG138 ma-jd-viral-33583
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18029
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18029
Apoptosis regulator MC163R ma-jd-viral-65459
Assembly protein G7 ma-jd-viral-34303
Assembly protein G7 ma-jd-viral-34303
B-H-3 protein (MC143R) ma-jd-viral-16418
B-H-5 protein (MC145R) ma-jd-viral-11885
B-M,N,L.6 protein (MC016L) ma-jd-viral-04028
B1-44-2 protein (MC091L) ma-jd-viral-52253
B1-60-2 protein (MC105L) ma-jd-viral-57751
B2-14.2 protein (MC068R) ma-jd-viral-23590
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22624
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) ma-jd-viral-22624
Chemokine-like protein MC148 ma-jd-viral-56397
Core protein VP8 ma-jd-viral-55844
Core protein VP8 ma-jd-viral-55844
DNA packaging protein OPG160 ma-jd-viral-10784
DNA packaging protein OPG160 ma-jd-viral-10784
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17208
DNA polymerase (EC 2.7.7.7) ma-jd-viral-17208
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17674
DNA topoisomerase (EC 5.6.2.1) ma-jd-viral-17674
DNA-directed RNA polymerase (EC 2.7.7.6) ma-jd-viral-35650
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39177
DNA-directed RNA polymerase 147 kDa polypeptide (EC 2.7.7.6) ma-jd-viral-39177
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07230
DNA-directed RNA polymerase 18 kDa subunit (EC 2.7.7.6) ma-jd-viral-07230
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53631
DNA-directed RNA polymerase 19 kDa subunit (EC 2.7.7.6) ma-jd-viral-53631
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13926
DNA-directed RNA polymerase 35 kDa subunit (EC 2.7.7.6) ma-jd-viral-13926
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66489
DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6) ma-jd-viral-66489
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01525
DNA-directed RNA polymerase subunit (EC 2.7.7.6) ma-jd-viral-01525
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23087
Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small... ma-jd-viral-23087
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40197
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40197
Entry-fusion complex protein OPG086 ma-jd-viral-02196
Entry-fusion complex protein OPG086 ma-jd-viral-02196
Envelope protein A28 homolog (Protein MC134) ma-jd-viral-31647
Envelope protein F13 homolog (43 kDa protein) (p43K) ma-jd-viral-42877
Glutaredoxin-2 ma-jd-viral-24238
Glutaredoxin-2 ma-jd-viral-24238
Glutathione peroxidase (GPx) (GSHPx) (EC 1.11.1.9) ma-jd-viral-29196
H-I.1-2 protein (MC136L) ma-jd-viral-44662
H-M-N-4 protein (MC149R) ma-jd-viral-06642
H-M-N-7 protein (MC152R) ma-jd-viral-10535
Intermediate transcription factor 3 large subunit ma-jd-viral-00028
Intermediate transcription factor 3 large subunit ma-jd-viral-00028
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-64857
Late transcription elongation factor OPG087 ma-jd-viral-65979
Late transcription elongation factor OPG087 ma-jd-viral-65979
Late transcription factor 1 ma-jd-viral-21456
MC001R ma-jd-viral-64939
MC002L ma-jd-viral-59742
MC003L ma-jd-viral-24340
MC004L ma-jd-viral-53171
MC006L ma-jd-viral-47281
MC007L ma-jd-viral-34857
MC008L ma-jd-viral-09679
MC008L ma-jd-viral-09679
MC009L ma-jd-viral-64905
MC010R ma-jd-viral-54399
MC010R ma-jd-viral-54399
MC011L ma-jd-viral-38747
MC012L ma-jd-viral-29219
MC012L ma-jd-viral-29219
MC013L (Putative molecular chaperone) ma-jd-viral-36163
MC014R ma-jd-viral-58472
MC015L ma-jd-viral-53055
MC015L ma-jd-viral-53055
MC016L ma-jd-viral-04028
MC018L ma-jd-viral-52993
MC019L ma-jd-viral-56867
MC019L ma-jd-viral-56867
MC020L ma-jd-viral-33750
MC020L ma-jd-viral-33750
MC021L ma-jd-viral-42877
MC022L ma-jd-viral-34163
MC022L ma-jd-viral-34163
MC023L ma-jd-viral-55507
MC023L ma-jd-viral-55507
MC024L ma-jd-viral-47755
MC025L ma-jd-viral-50615
MC025L ma-jd-viral-50615
MC026L ma-jd-viral-62181
MC026L ma-jd-viral-62181
MC027L ma-jd-viral-01240
MC027L ma-jd-viral-01240
MC028L ma-jd-viral-42317
MC028L ma-jd-viral-42317
MC030R ma-jd-viral-63873
MC030R ma-jd-viral-63873
MC032L ma-jd-viral-04660
MC032L ma-jd-viral-04660
MC033L ma-jd-viral-67400
MC033L ma-jd-viral-67400
MC034L ma-jd-viral-34008
MC034L ma-jd-viral-34008
MC036R ma-jd-viral-59393
MC041L ma-jd-viral-04639
MC041L ma-jd-viral-04639
MC042L ma-jd-viral-04672
MC043L ma-jd-viral-35402
MC043L ma-jd-viral-35402
MC044L ma-jd-viral-02068
MC044L ma-jd-viral-02068
MC045L ma-jd-viral-39140
MC045L ma-jd-viral-39140
MC047L ma-jd-viral-51120
MC048L ma-jd-viral-63595
MC048L ma-jd-viral-63595
MC049L ma-jd-viral-06329
MC051L ma-jd-viral-16508
MC052R ma-jd-viral-42331
MC053L ma-jd-viral-16509
MC054L ma-jd-viral-32058
MC055R ma-jd-viral-66780
MC063L ma-jd-viral-48265
MC063L ma-jd-viral-48265
MC064R ma-jd-viral-39477
MC064R ma-jd-viral-39477
MC068R ma-jd-viral-23590
MC069R ma-jd-viral-04046
MC069R ma-jd-viral-04046
MC070R ma-jd-viral-44698
MC070R ma-jd-viral-44698
MC071R ma-jd-viral-50818
MC071R ma-jd-viral-50818
MC072L ma-jd-viral-04847
MC072L ma-jd-viral-04847
MC074R ma-jd-viral-22170
MC074R ma-jd-viral-22170
MC075R ma-jd-viral-34505
MC075R ma-jd-viral-34505
MC078L ma-jd-viral-35568
MC078L ma-jd-viral-35568
MC080R ma-jd-viral-29468
MC080R ma-jd-viral-29468
MC081R ma-jd-viral-38680
MC081R ma-jd-viral-38680
MC082L ma-jd-viral-06231
MC082L ma-jd-viral-06231
MC083R ma-jd-viral-38039
MC083R ma-jd-viral-38039
MC084L ma-jd-viral-18658
MC084L ma-jd-viral-18658
MC086R ma-jd-viral-43356
MC086R ma-jd-viral-43356
MC088R ma-jd-viral-00550
MC088R ma-jd-viral-00550
MC089L ma-jd-viral-49519
MC089L ma-jd-viral-49519
MC091L ma-jd-viral-52253
MC092R ma-jd-viral-01698
MC092R ma-jd-viral-01698
MC094R ma-jd-viral-34222
MC094R ma-jd-viral-34222
MC096L ma-jd-viral-49287
MC096L ma-jd-viral-49287
MC098R ma-jd-viral-07973
MC098R ma-jd-viral-07973
MC099R ma-jd-viral-07889
MC099R ma-jd-viral-07889
MC101L ma-jd-viral-09991
MC101L ma-jd-viral-09991
MC105L ma-jd-viral-57751
MC107L ma-jd-viral-50079
MC109L ma-jd-viral-03899
MC109L ma-jd-viral-03899
MC112L ma-jd-viral-32248
MC113L ma-jd-viral-60212
MC113L ma-jd-viral-60212
MC114R ma-jd-viral-33152
MC116R ma-jd-viral-57296
MC116R ma-jd-viral-57296
MC117L ma-jd-viral-66661
MC117L ma-jd-viral-66661
MC118L ma-jd-viral-56064
MC118L ma-jd-viral-56064
MC119L ma-jd-viral-50921
MC119L ma-jd-viral-50921
MC120L ma-jd-viral-37101
MC120L ma-jd-viral-37101
MC121L ma-jd-viral-22776
MC122L ma-jd-viral-00057
MC122L ma-jd-viral-00057
MC123R ma-jd-viral-23207
MC124L ma-jd-viral-33656
MC124L ma-jd-viral-33656
MC125L ma-jd-viral-00085
MC125L ma-jd-viral-00085
MC126R ma-jd-viral-54852
MC127R ma-jd-viral-29058
MC130L ma-jd-viral-04541
MC131L ma-jd-viral-04528
MC132L ma-jd-viral-39535
MC133L ma-jd-viral-04542
MC136L ma-jd-viral-44662
MC137L ma-jd-viral-44338
MC137L (Putative secreted protein) ma-jd-viral-44338
MC138R ma-jd-viral-44799
MC138R ma-jd-viral-44799
MC139R ma-jd-viral-38980
MC139R ma-jd-viral-38980
MC141R ma-jd-viral-52780
MC141R ma-jd-viral-52780
MC143R ma-jd-viral-16418
MC144R ma-jd-viral-42119
MC144R ma-jd-viral-42119
MC145R ma-jd-viral-11885
MC146R ma-jd-viral-61390
MC147R ma-jd-viral-31937
MC149R ma-jd-viral-06642
MC150R ma-jd-viral-36908
MC151L ma-jd-viral-66726
MC152R ma-jd-viral-10535
MC153R ma-jd-viral-44376
MC154R ma-jd-viral-54598
MC154R ma-jd-viral-54598
MC155R ma-jd-viral-40108
MC155R ma-jd-viral-40108
MC156R ma-jd-viral-51141
MC156R ma-jd-viral-51141
MC157R ma-jd-viral-56178
MC158R ma-jd-viral-66271
MC158R ma-jd-viral-66271
MC159L ma-jd-viral-16384
MC161R ma-jd-viral-55657
MC162R ma-jd-viral-66994
MC60R ma-jd-viral-22447
MC60R ma-jd-viral-22447
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23054
Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH... ma-jd-viral-23054
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large... ma-jd-viral-36192
Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit)... ma-jd-viral-36192
Probable metalloendopeptidase G1-type (EC 3.4.24.-) ma-jd-viral-04457
Protein E6 homolog ma-jd-viral-36817
Protein MC005 ma-jd-viral-43743
Protein MC007 ma-jd-viral-34857
Protein MC014 ma-jd-viral-58472
Protein MC132 ma-jd-viral-39535
Protein MC160 ma-jd-viral-30891
Protein OPG061 ma-jd-viral-14933
Protein OPG061 ma-jd-viral-14933
Protein OPG070 ma-jd-viral-64800
Protein OPG070 ma-jd-viral-64800
Protein OPG079 ma-jd-viral-12916
Protein OPG079 ma-jd-viral-12916
Protein OPG091 ma-jd-viral-06091
Protein OPG091 ma-jd-viral-06091
Protein OPG161 ma-jd-viral-03064
Protein OPG161 ma-jd-viral-03064
Putative major envelope protein ma-jd-viral-42877
RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH... ma-jd-viral-58252
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63409
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63409
Serine/threonine-protein kinase (EC 2.7.11.1) ma-jd-viral-24798
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34807
Sulfhydryl oxidase (EC 1.8.3.2) ma-jd-viral-34807
Uracil-DNA glycosylase ma-jd-viral-07777
Uracil-DNA glycosylase ma-jd-viral-07777
Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein)... ma-jd-viral-16384
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16055
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16055
Viral late gene transcription factor 3 ma-jd-viral-52661
Viral late gene transcription factor 3 ma-jd-viral-52661
Virion core protein 4b ma-jd-viral-62982
mRNA-capping enzyme catalytic subunit (EC 2.1.1.56) (EC 2.7.7.50) (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41032