Vesiculovirus (taxid:11271)

Vesiculovirus is a genus of ssRNA- viruses in the family Rhabdoviridae that infect mammals. These viruses are transmitted by insects (arbovirus) and rarely infect humans in which they cause flu-like disease that can lead to encephalitis.

VIRION

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Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

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Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

57 entries grouped by protein

8 entries

Protein C'

Select_allDeselect_all
C_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
C_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
C_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
C_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
C_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
C_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
C_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)
C_VSNJM
Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)

11 entries

Glycoprotein

Select_allDeselect_all
GLYCO_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
GLYCO_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
GLYCO_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
GLYCO_COCAV
Cocal virus (COCV)
GLYCO_ISFV
Isfahan virus (ISFV)
GLYCO_PIRYV
Piry virus (PIRYV)
GLYCO_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
GLYCO_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
GLYCO_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
GLYCO_VSIVO
Vesicular stomatitis Indiana virus (strain Orsay) (VSIV)
GLYCO_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

9 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
L_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
L_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
L_ISFV
Isfahan virus (ISFV)
L_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
L_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
L_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
L_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)
L_VSNJH
Vesicular stomatitis New Jersey virus (strain Hazelhurst subtype Hazelhurst) (VSNJV)

9 entries

Matrix protein (M protein)

Select_allDeselect_all
MATRX_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain

Matrix protein

MATRX_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
MATRX_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

Matrix protein

MATRX_ISFV
Isfahan virus (ISFV)

Matrix protein

MATRX_PIRYV
Piry virus (PIRYV)

Matrix protein

MATRX_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
MATRX_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
MATRX_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
MATRX_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

9 entries

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
NCAP_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
NCAP_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
NCAP_ISFV
Isfahan virus (ISFV)
NCAP_PIRYV
Piry virus (PIRYV)
NCAP_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
NCAP_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
NCAP_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
NCAP_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

11 entries

Phosphoprotein (Protein P) (Protein M1)

Select_allDeselect_all
PHOSP_CHAV
Chandipura virus (strain I653514) (CHPV) reference strain
PHOSP_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

Phosphoprotein (P protein) (Protein M1)

PHOSP_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

Phosphoprotein (P protein) (Protein M1)

PHOSP_ISFV
Isfahan virus (ISFV)
PHOSP_PIRYV
Piry virus (PIRYV)
PHOSP_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
PHOSP_VSIVM
Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
PHOSP_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

Phosphoprotein (Protein P) (NS) (Protein M1)

PHOSP_VSNJM
Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Chandipura virus taxid:11272

Protein ModelArchive
Glycoprotein ma-jd-viral-07124
Matrix protein ma-jd-viral-11579
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15201
Phosphoprotein (Protein M1) ma-jd-viral-41126

Chandipura virus (strain I653514) taxid:11273

Protein ModelArchive
Matrix protein ma-jd-viral-11579

Isfahan virus taxid:290008

Protein ModelArchive
Glycoprotein ma-jd-viral-07130
Matrix protein ma-jd-viral-11571
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15172
Phosphoprotein (Protein P) (Protein M1) ma-jd-viral-41131

Vesicular stomatitis Alagoas virus taxid:198833

Protein ModelArchive
Glycoprotein ma-jd-viral-07111
Matrix protein ma-jd-viral-11573
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15092
Phosphoprotein (Protein M1) ma-jd-viral-41128

Vesicular stomatitis Indiana virus taxid:11277

Protein ModelArchive
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15153

Vesicular stomatitis Indiana virus (strain 98COE North America) taxid:434488

Protein ModelArchive
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15153

Vesicular stomatitis Indiana virus (strain San Juan) taxid:11285

Protein ModelArchive
Matrix protein (M protein) ma-jd-viral-11572
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N) ma-jd-viral-15153
Phosphoprotein (P protein) (Protein M1) ma-jd-viral-41125

Vesicular stomatitis New Jersey virus taxid:11280

Protein ModelArchive
Glycoprotein ma-jd-viral-07057
Matrix protein ma-jd-viral-11574
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-15178
Phosphoprotein (Protein M1) ma-jd-viral-41130