Orthomarburgvirus (taxid:3044783)
Filamentous, greatly variable up to 1400 nm in length. Diameter is about 80nm.
GENOME
Negative-stranded RNA linear genome, about 19 kb in size. Encodes for seven proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. RNA editing may occur at NP gene.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
REPLICATION
CYTOPLASMIC
- Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry.
- Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
- Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.
Host-virus interaction
Inhibition of host interferon signaling
Vp40 protein prevents interferon signaling by preventing the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2. 
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Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)35 entries grouped by protein
5 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
5 entries
Nucleoprotein (Nucleocapsid protein)
5 entries
Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein)
5 entries
Membrane-associated protein VP24 (Marburg VP24) (mVP24)
5 entries
Transcriptional activator VP30 (Minor nucleoprotein VP30)
5 entries
Polymerase cofactor VP35 (Marburg VP35) (mVP35)
5 entries