Rhabdoviridae

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide. Certain plant rhabdoviruses are bacilliform in shape and almost twice the length.

GENOME

Negative-stranded RNA linear genome, about 11-15 kb in size. Varicosavirus genomes consists in two segments. Encodes for 5 to six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Inhibition of host Interferon induction

Rabies nucleoprotein plays a role in inhibition of RIG-I antiviral signaling
Rabies phosphoprotein may inhibit IRF-3 phosphorylation

Inhibition of host type I interferon signaling

Rabies phosphoprotein may inhibit STAT-I antiviral pathway signaling by preventing nuclear localization of STAT dimers upon activation.

Matching UniProtKB/Swiss-Prot entries

244 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 286 entries)

12 entries

Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

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L_BEFVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_BEFVB Matrix protein
NCAP_BEFVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VPB_BEFVB Protein beta
PHOSP_BEFVB Phosphoprotein (Protein P) (Protein M1)
VGLN_BEFVB Non-structural glycoprotein GNS
VPP_BEFVB Putative protein P'
VPA2_BEFVB Protein alpha-2
VPG_BEFVB Protein gamma
VPA1_BEFVB Protein alpha-1
GLYCO_BEFVB Glycoprotein
VPA3_BEFVB Protein alpha-3

9 entries

Tibrogargan virus (strain CS132) (TIBV) reference strain

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MATRX_TIBVC Matrix protein
U4_TIBVC Uncharacterized protein U4
U3_TIBVC Protein U3
U2_TIBVC Protein U2
PHOSP_TIBVC Phosphoprotein (P protein)
NCAP_TIBVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_TIBVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
U1_TIBVC Protein U1
GLYCO_TIBVC Glycoprotein

8 entries

Northern cereal mosaic virus (NCMV) reference strain

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MATRX_NCMV Matrix protein
NCAP_NCMV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_NCMV Phosphoprotein (Protein P) (Protein M1)
VP6_NCMV Protein 6
VP3_NCMV Protein 3
GLYCO_NCMV Glycoprotein
VP4_NCMV Protein 4
VP5_NCMV Protein 5

7 entries

Rice yellow stunt virus (RYSV) (Rice transitory yellowing virus) reference strain

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MVP_RYSV Movement protein (MP) (Cell-to-cell transport protein) (Protein 3)
MATRX_RYSV Matrix protein
L_RYSV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP6_RYSV Protein 6
NCAP_RYSV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RYSV Phosphoprotein (Protein P) (Protein M1)
GLYCO_RYSV Glycoprotein

7 entries

Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

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C_TUPVT Protein C
PHOSP_TUPVT Phosphoprotein (P protein)
L_TUPVT RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_TUPVT Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
SH_TUPVT Small hydrophobic protein (Protein SH)
MATRX_TUPVT Matrix protein
GLYCO_TUPVT Glycoprotein

6 entries

Drosophila melanogaster sigma virus (isolate Drosophila/USA/AP30/2005) (DMelSV) reference strain

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PP3_DMSVA Protein PP3
MATRX_DMSVA Matrix protein
L_DMSVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_DMSVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_DMSVA Phosphoprotein (P protein)
GLYCO_DMSVA Glycoprotein

6 entries

Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV) reference strain

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L_HIRRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_HIRRV Matrix protein
NV_HIRRV Non-virion protein
NCAP_HIRRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_HIRRV Phosphoprotein (Protein P) (Protein M1)
GLYCO_HIRRV Glycoprotein

6 entries

Infectious hematopoietic necrosis virus (strain WRAC) (IHNV) reference strain

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MATRX_IHNVW Matrix protein (Protein M2)
L_IHNVW RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_IHNVW Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
NV_IHNVW Non-virion protein
PHOSP_IHNVW Phosphoprotein (Protein P) (Protein M1)
GLYCO_IHNVW Glycoprotein (Spike glycoprotein)

6 entries

Lettuce big-vein associated virus (isolate Japan/Kagawa) (LBVaV) reference strain

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L_LBVAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP5_LBVAV Protein 5
VP2_LBVAV Protein 2
VP3_LBVAV Protein 3
NCAP_LBVAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
VP4_LBVAV Protein 4

6 entries

Lettuce necrotic yellows virus (isolate 318) (LNYV) reference strain

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NCAP_LNYV3 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MVP_LNYV3 Probable movement protein 4b (MP) (Cell-to-cell transport protein) (Protein 4b)
L_LNYV3 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_LNYV3 Matrix protein
GLYCO_LNYV3 Glycoprotein
VP4A_LNYV3 Phosphoprotein (Protein P) (Protein 4a)

6 entries

Maize mosaic virus (isolate Maize/United States/Reed/2005) (MMV) reference strain

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MATRX_MMVR Matrix protein
NCAP_MMVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MMVR Phosphoprotein (Protein P) (Protein M1)
L_MMVR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MVP_MMVR Putative movement protein 3 (MP) (Cell-to-cell transport protein) (Protein 3)
GLYCO_MMVR Glycoprotein

6 entries

Snakehead rhabdovirus (SHRV) reference strain

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L_SHRV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_SHRV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_SHRV Matrix protein
PHOSP_SHRV Phosphoprotein (Protein P) (Protein M1)
NV_SHRV Non-virion protein
GLYCO_SHRV Glycoprotein

6 entries

Sonchus yellow net virus (SYNV) reference strain

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L_SYNV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_SYNV Matrix protein (M2 protein)
PHOSP_SYNV Phosphoprotein (Protein P) (Protein M1)
MVP_SYNV Movement protein (MP) (Cell-to-cell transport protein) (Protein Sc4)
NCAP_SYNV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_SYNV Spike glycoprotein

6 entries

Taro vein chlorosis virus (TAVCV) reference strain

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MVP_TAVCV Movement protein (MP) (Cell-to-cell transport protein) (Protein 3)
MATRX_TAVCV Matrix protein
L_TAVCV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_TAVCV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_TAVCV Phosphoprotein (Protein P) (Protein M1)
GLYCO_TAVCV Glycoprotein

6 entries

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

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L_VSIVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVA Matrix protein
PHOSP_VSIVA Phosphoprotein (P protein) (Protein M1)
NCAP_VSIVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
C_VSIVA Protein C'
GLYCO_VSIVA Glycoprotein

6 entries

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain

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PHOSP_VSNJO Phosphoprotein (P protein) (Protein M1)
L_VSNJO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSNJO Matrix protein
NCAP_VSNJO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_VSNJO Glycoprotein
C_VSNJO Protein C'

5 entries

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

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L_ABLVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVB Matrix protein (Phosphoprotein M2)
NCAP_ABLVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVB Glycoprotein

5 entries

Chandipura virus (strain I653514) (CHPV) reference strain

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NCAP_CHAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_CHAV Matrix protein
L_CHAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_CHAV Phosphoprotein (Protein P) (Protein M1)
GLYCO_CHAV Glycoprotein

5 entries

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

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L_EBLV1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_EBLV1 Matrix protein
PHOSP_EBLV1 Phosphoprotein (Protein P) (Protein M1)
NCAP_EBLV1 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_EBLV1 Glycoprotein

5 entries

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

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L_EBLV2 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_EBLV2 Matrix protein
NCAP_EBLV2 Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_EBLV2 Phosphoprotein (Protein P) (Protein M1)
GLYCO_EBLV2 Glycoprotein

5 entries

Mokola virus (MOKV) reference strain

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L_MOKV Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_MOKV Matrix protein (Phosphoprotein M2)
NCAP_MOKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_MOKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_MOKV Glycoprotein

5 entries

Rabies virus (strain China/DRV) (RABV) reference strain

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MATRX_RABVD Matrix protein (Phosphoprotein M2)
L_RABVD Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVD Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVD Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVD Glycoprotein

5 entries

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

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MATRX_RABVP Matrix protein (Phosphoprotein M2)
L_RABVP Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVP Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVP Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVP Glycoprotein

5 entries

Rabies virus (strain SAD B19) (RABV) reference strain

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MATRX_RABVS Matrix protein (Phosphoprotein M2)
L_RABVS Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVS Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVS Glycoprotein

5 entries

Spring viremia of carp virus (Rhabdovirus carpia) reference strain

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MATRX_SVCV Matrix protein
L_SVCV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_SVCV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_SVCV Phosphoprotein (P protein) (Protein P) (Protein M1)
GLYCO_SVCV Glycoprotein

4 entries

Irkut virus (IRKV) reference strain

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MATRX_IRKV Matrix protein (Phosphoprotein M2)
NCAP_IRKV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_IRKV Phosphoprotein (Protein P) (Protein M1)
GLYCO_IRKV Glycoprotein

4 entries

West Caucasian bat virus (WCBV) reference strain

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PHOSP_WCBV Phosphoprotein (Protein P) (Protein M1)
NCAP_WCBV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_WCBV Matrix protein (Phosphoprotein M2)
GLYCO_WCBV Glycoprotein

6 entries

Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)

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NV_IHNVO Non-virion protein
PHOSP_IHNVO Phosphoprotein (Protein P) (Protein M1)
L_IHNVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_IHNVO Matrix protein (Protein M2)
NCAP_IHNVO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_IHNVO Glycoprotein (Spike glycoprotein)

6 entries

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

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NCAP_VSIVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_VSIVS RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVS Matrix protein
PHOSP_VSIVS Phosphoprotein (Protein P) (NS) (Protein M1)
C_VSIVS Protein C'
GLYCO_VSIVS Glycoprotein

6 entries

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

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PHOSP_VSIVC Phosphoprotein (Protein P) (NS) (Protein M1)
MATRX_VSIVC Matrix protein
C_VSIVC Protein C'
L_VSIVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_VSIVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_VSIVC Glycoprotein

6 entries

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

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L_VSIVN RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVN Matrix protein
PHOSP_VSIVN Phosphoprotein (Protein P) (NS) (Protein M1)
NCAP_VSIVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
C_VSIVN Protein C'
GLYCO_VSIVN Glycoprotein

5 entries

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

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L_ABLVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_ABLVH Matrix protein (Phosphoprotein M2)
NCAP_ABLVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ABLVH Phosphoprotein (Protein P) (Protein M1)
GLYCO_ABLVH Glycoprotein

5 entries

Isfahan virus (ISFV)

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MATRX_ISFV Matrix protein
L_ISFV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_ISFV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_ISFV Phosphoprotein (Protein P) (Protein M1)
GLYCO_ISFV Glycoprotein

5 entries

Rabies virus (strain China/MRV) (RABV)

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MATRX_RABVR Matrix protein (Phosphoprotein M2)
L_RABVR Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVR Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVR Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVR Glycoprotein

5 entries

Rabies virus (strain ERA) (RABV)

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L_RABVE Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVE Matrix protein (Phosphoprotein M2)
PHOSP_RABVE Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVE Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVE Glycoprotein

5 entries

Rabies virus (strain HEP-Flury) (RABV)

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L_RABVH Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVH Matrix protein (Phosphoprotein M2)
PHOSP_RABVH Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVH Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVH Glycoprotein

5 entries

Rabies virus (strain India) (RABV)

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L_RABVI Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVI Matrix protein (Phosphoprotein M2)
PHOSP_RABVI Phosphoprotein (Protein P) (Protein M1)
NCAP_RABVI Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_RABVI Glycoprotein

5 entries

Rabies virus (strain Nishigahara RCEH) (RABV)

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L_RABVN Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
MATRX_RABVN Matrix protein (Phosphoprotein M2)
NCAP_RABVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
PHOSP_RABVN Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVN Glycoprotein

5 entries

Rabies virus (strain PM1503/AVO1) (RABV)

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NCAP_RABVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_RABVA Matrix protein (Phosphoprotein M2)
L_RABVA Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
GLYCO_RABVA Glycoprotein
PHOSP_RABVA Phosphoprotein (Protein P) (Protein M1)

5 entries

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

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MATRX_RABVB Matrix protein (Phosphoprotein M2)
L_RABVB Large structural protein (Protein L) (Replicase) (Transcriptase) [Includes: RNA-directed RNA ...
PHOSP_RABVB Phosphoprotein (Protein P) (Protein M1)
GLYCO_RABVB Glycoprotein
NCAP_RABVB Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

5 entries

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)

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MATRX_VSIVG Matrix protein
C_VSIVG Protein C'
PHOSP_VSIVG Phosphoprotein (Protein P) (Protein M1)
NCAP_VSIVG Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_VSIVG Glycoprotein

4 entries

Aravan virus (ARAV)

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GLYCO_ARAV Glycoprotein
PHOSP_ARAV Phosphoprotein (Protein P) (Protein M1)
MATRX_ARAV Matrix protein (Phosphoprotein M2)
NCAP_ARAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

4 entries

Khujand virus (KHUV)

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MATRX_KHUV Matrix protein (Phosphoprotein M2)
PHOSP_KHUV Phosphoprotein (Protein P) (Protein M1)
NCAP_KHUV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
GLYCO_KHUV Glycoprotein