Paramyxoviridae

VIRION

Enveloped, spherical. Diameter of about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. Most express a C protein by leaky scanning and V/W proteins by mRNA editing.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN, H or G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthesized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The Nipah P,V and W proteins play a role in inhibition of STAT1 antiviral signaling

The Sendai C protein plays a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

136 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 316 entries)

9 entries

Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain

Select_allDeselect_all
MATRX_HENDH Matrix protein (Protein M)
L_HENDH RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
W_HENDH Protein W
PHOSP_HENDH Phosphoprotein (Protein P)
NCAP_HENDH Nucleoprotein (Protein N) (Nucleocapsid protein)
GLYCP_HENDH Glycoprotein G
C_HENDH Protein C
FUS_HENDH Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_HENDH Non-structural protein V

8 entries

Nipah virus reference strain

Select_allDeselect_all
MATRX_NIPAV Matrix protein (Protein M)
L_NIPAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_NIPAV Nucleoprotein (Protein N) (Nucleocapsid protein)
W_NIPAV Protein W
PHOSP_NIPAV Phosphoprotein (Protein P)
V_NIPAV Non-structural protein V
GLYCP_NIPAV Glycoprotein G
FUS_NIPAV Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

8 entries

Sendai virus (strain Hamamatsu) (SeV) reference strain

Select_allDeselect_all
MATRX_SENDA Matrix protein (M protein)
C_SENDA Protein C'
HN_SENDA Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
L_SENDA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_SENDA Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_SENDA Phosphoprotein (Protein P)
NCAP_SENDA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_SENDA Protein V

7 entries

Sendai virus (strain Ohita) (SeV) reference strain

Select_allDeselect_all
FUS_SENDO Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
C_SENDO Protein C'
PHOSP_SENDO Phosphoprotein (Protein P)
L_SENDO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_SENDO Hemagglutinin-neuraminidase (HN protein) (Protein HANA) (EC 3.2.1.18)
NCAP_SENDO Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_SENDO Matrix protein (M protein)

7 entries

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Select_allDeselect_all
C_SENDZ C' protein
MATRX_SENDZ Matrix protein (M protein)
V_SENDZ Protein V
W_SENDZ Protein W
PHOSP_SENDZ Phosphoprotein (Protein P)
NCAP_SENDZ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_SENDZ Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

8 entries

Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain

Select_allDeselect_all
HEMA_MEASC Hemagglutinin glycoprotein
C_MEASC Protein C
MATRX_MEASC Matrix protein
L_MEASC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MEASC Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MEASC Phosphoprotein (Protein P)
V_MEASC Non-structural protein V
FUS_MEASC Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

8 entries

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Select_allDeselect_all
MATRX_MUMPM Matrix protein
NCAP_MUMPM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_MUMPM Phosphoprotein (Protein P)
L_MUMPM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
SH_MUMPM Small hydrophobic protein
HN_MUMPM Hemagglutinin-neuraminidase (EC 3.2.1.18)
V_MUMPM Non-structural protein V (Non-structural protein NS1)
FUS_MUMPM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

8 entries

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Select_allDeselect_all
L_NDVB1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_NDVB1 Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_NDVB1 Matrix protein
PHOSP_NDVB1 Phosphoprotein (Protein P)
NCAP_NDVB1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
W_NDVB1 Protein W
FUS_NDVB1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_NDVB1 Protein V

8 entries

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

Select_allDeselect_all
HN_PIV5 Hemagglutinin-neuraminidase (EC 3.2.1.18)
L_PIV5 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_PIV5 Matrix protein (Membrane protein)
PHOSP_PIV5 Phosphoprotein (Protein P)
NCAP_PIV5 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
SH_PIV5 Small hydrophobic protein
FUS_PIV5 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
V_PIV5 Non-structural protein V

7 entries

Human parainfluenza 2 virus (strain Toshiba) (HPIV-2) reference strain

Select_allDeselect_all
L_PI2HT RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_PI2HT Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_PI2HT Matrix protein (Membrane protein)
PHOSP_PI2HT Phosphoprotein (Protein P)
NCAP_PI2HT Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_PI2HT Non-structural protein V
FUS_PI2HT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

7 entries

Rinderpest virus (strain RBOK) (RDV) reference strain

Select_allDeselect_all
C_RINDR Protein C
HEMA_RINDR Hemagglutinin glycoprotein
MATRX_RINDR Matrix protein
L_RINDR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_RINDR Phosphoprotein (Protein P)
NCAP_RINDR Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_RINDR Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

6 entries

Simian virus 41 (SV41) reference strain

Select_allDeselect_all
FUS_SV41 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_SV41 Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_SV41 Matrix protein
L_SV41 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
V_SV41 Non-structural protein V
NCAP_SV41 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

4 entries

Tupaia paramyxovirus (TPMV) reference strain

Select_allDeselect_all
C_TPMV Protein C
NCAP_TPMV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
PHOSP_TPMV Phosphoprotein (Protein P)
V_TPMV Non-structural protein V

2 entries

Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Select_allDeselect_all
L_CDVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_CDVO Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Nipah virus

C_NIPAV Protein C

9 entries

Sendai virus (strain Fushimi) (SeV)

Select_allDeselect_all
HN_SENDF Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)
L_SENDF RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_SENDF Fusion glycoprotein F0 (Protein F) [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
PHOSP_SENDF Phosphoprotein (Protein P)
MATRX_SENDF Matrix protein (M protein)
C_SENDF Protein C'
NCAP_SENDF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
W_SENDF Protein W
V_SENDF Protein V

1 entry

Sendai virus (strain Hamamatsu) (SeV)

W_SENDA Protein W

2 entries

Sendai virus (strain Ohita) (SeV)

Select_allDeselect_all
V_SENDO Protein V
W_SENDO Protein W

2 entries

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Select_allDeselect_all
L_SENDZ RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HN_SENDZ Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

8 entries

Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
L_MEASA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_MEASA Matrix protein
HEMA_MEASA Hemagglutinin glycoprotein
C_MEASA Protein C
PHOSP_MEASA Phosphoprotein (Protein P)
NCAP_MEASA Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_MEASA Non-structural protein V
FUS_MEASA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

6 entries

Bovine parainfluenza 3 virus (BPIV-3)

Select_allDeselect_all
PHOSP_PI3B Phosphoprotein (Protein P)
HN_PI3B Hemagglutinin-neuraminidase (EC 3.2.1.18)
MATRX_PI3B Matrix protein
NCAP_PI3B Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
C_PI3B Protein C
FUS_PI3B Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

6 entries

Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)

Select_allDeselect_all
MATRX_MEASE Matrix protein
L_MEASE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
HEMA_MEASE Hemagglutinin glycoprotein
NCAP_MEASE Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
V_MEASE Non-structural protein V
FUS_MEASE Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

1 entry

Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASM Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)

NCAP_MEASW Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Mumps virus (strain Jeryl-Lynn) (MuV)

NCAP_MUMPJ Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Peste-des-petits-ruminants virus (PPRV)

NCAP_PPRV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)