Hantaviridae

VIRION

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Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

45 entries grouped by strain (browse by keywords)

3 entries

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Select_allDeselect_all
L_HANTV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
GP_HANTV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...
NCAP_HANTV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

2 entries

Seoul virus (strain 80-39) reference strain

Select_allDeselect_all
L_SEOU8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
GP_SEOU8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

4 entries

Andes orthohantavirus (ANDV) (Andes virus)

Select_allDeselect_all
L_ANDV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
NSS_ANDV Non-structural protein NS-S (NSs)
NCAP_ANDV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)
GP_ANDV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

4 entries

Puumala virus (strain Bank vole/Russia/CG1820/1984)

Select_allDeselect_all
L_PUUMG RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
GP_PUUMG Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NSS_PUUMG Non-structural protein NS-S (NSs)
NCAP_PUUMG Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

4 entries

Puumala virus (strain Sotkamo/V-2969/81)

Select_allDeselect_all
L_PUUMS RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
GP_PUUMS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NSS_PUUMS Non-structural protein NS-S (NSs)
NCAP_PUUMS Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

4 entries

Tula orthohantavirus (TULV) (Tula virus)

Select_allDeselect_all
NSS_TULV Non-structural protein NS-S (NSs)
L_TULV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
GP_TULV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...
NCAP_TULV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

3 entries

Black Creek Canal orthohantavirus (BCCV) (Black Creek Canal virus)

Select_allDeselect_all
L_BCCV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
NCAP_BCCV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)
GP_BCCV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

3 entries

Dobrava-Belgrade orthohantavirus (DOBV) (Dobrava virus)

Select_allDeselect_all
L_DOBV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
NCAP_DOBV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)
GP_DOBV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...

3 entries

Sin Nombre orthohantavirus (SNV) (Sin Nombre virus)

Select_allDeselect_all
GP_SINV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_SINV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (RdRp) ...
NCAP_SINV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

2 entries

Prospect Hill virus (PHV)

Select_allDeselect_all
GP_PHV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PHV Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

2 entries

Puumala virus (strain K27)

Select_allDeselect_all
GP_PUUMK Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PUUMK Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

2 entries

Puumala virus (strain P360)

Select_allDeselect_all
GP_PUUMP Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PUUMP Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

2 entries

Seoul virus (strain SR-11) (Sapporo rat virus)

Select_allDeselect_all
GP_SEOUS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_SEOUS Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

1 entry

Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)

GP_HANTB Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)

GP_HANTH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)

GP_HANTL Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

New York virus (NYV)

GP_NYV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Puumala virus (strain Evo/12CG/93)

NCAP_PUUME Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

1 entry

Puumala virus (strain Udmurtia/894CG/91)

NCAP_PUUMU Nucleoprotein (EC 3.1.-.-) (Nucleocapsid protein) (Protein N)

1 entry

Seoul virus (strain R22)

GP_SEOUR Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...