Hantaviridae

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

14 entries grouped by strain (browse by keywords)

Only complete proteome entries are shown (view all 28 entries)

4 entries

Puumala virus (strain Sotkamo/V-2969/81) reference strain

Select_allDeselect_all
NSS_PUUMS Non-structural protein NS-S (NSs)
GP_PUUMS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_PUUMS RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_PUUMS Nucleoprotein (Nucleocapsid protein) (Protein N)

3 entries

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Select_allDeselect_all
GP_HANTV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...
L_HANTV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_HANTV Nucleoprotein (Nucleocapsid protein) (Protein N)

4 entries

Puumala virus (strain Bank vole/Russia/CG1820/1984)

Select_allDeselect_all
L_PUUMG RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
GP_PUUMG Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PUUMG Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_PUUMG Non-structural protein NS-S (NSs)

2 entries

Seoul virus (strain 80-39)

Select_allDeselect_all
GP_SEOU8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_SEOU8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

1 entry

Prospect Hill virus (PHV)

GP_PHV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...