Picovirinae (taxid:542836)

VIRION

Non-enveloped, head-tail structure. Head is about 54 nm in diameter. The tail is non-contractile and has a collar with 12 appendages. The capsid is icosahedral with a T=3 symmetry.

GENOME

Linear, dsDNA genome of about 16 to 20 kb encoding between 20 and 30 genes.

GENE EXPRESSION

ENZYMES

DNA dependent DNA polymerase [DNA pol]
Protease (Peptidase G2) [Pre-neck appendage protein]
Endolysin

REPLICATION

CYTOPLASMIC

Adsorption: the phage attaches to the target cell via its tail fibers.
Ejection by short tail system: viral DNA is injected into the periplams of the host cell.
Transcription and translation of the early genes
Replication of genomic DNA by Strand displacement by viral DNA polymerase, formation of viral genome concatemers.
Transcription and translation of late genes
Assembly of empty procapsids and viral genome packaging.
Mature virions are released from the cell by lysis.

DB LINKS

TAXONOMY Group I: dsDNA viruses

Realm:	Duplodnaviria
Kingdom:	Heunggongvirae
Phylum:	Uroviricota
Class:	Caudoviricetes
Order:	Unassigned
Family:	Salasmaviridae
Subfamily:	Picovirinae
Genus:	Beecentumtrevirus Salasvirus

VIRUS

Bacillus virus phi29
Staphylococcus virus 44AHJD
Streptococcus virus Cp1
Actinomyces virus Av1
Bacillus virus B103
Bacillus virus GA1
Kurthia virus 6
Mycoplasma virus P1
Streptococcus virus C1
Streptococcus virus Cp7

REFERENCE STRAINS Bacillus phage phi29
Sequence | Genome assembly | Proteome Staphylococcus phage 44AHJD
Sequence | Genome assembly | Proteome

Host

NATURAL HOSTS Bacteria

Ecology and disease

GEOGRAPHY Worldwide

TRANSMISSION Passive diffusion through medium

ANTIVIRAL DRUGS

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

82 entries grouped by strain

reorder by protein

24 entries

Bacillus phage phi29 (Bacteriophage phi-29) reference strain

GP1_BPPH2 DNA replication protein 1 (Gene product 1) (gp1)

DPOL_BPPH2 DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 2) (gp2) (Protein p2)

1XHX; 1XHZ; 1XI1; 2EX3; 2PY5; 2PYJ; 2PYL; 2PZS

TERM_BPPH2 Primer terminal protein (TP) (DNA terminal protein) (Gene product 3) (gp3) (Protein p3) (Terminal ...

2EX3

NP_BPPH2 Histone-like protein p6 (Double-stranded DNA-binding protein p6) (Gene product 6) (gp6) ...

8PW2; 8PW4

PKG16_BPPH2 DNA packaging protein (ATPase gp16) (EC 3.6.4.-) (Gene product 16) (gp16) (Protein p16)

5HD9; 6V1W; 7CNB; 7JQQ

GP167_BPPH2 DNA replication protein 16.7 (Gene product 16.7) (gp16.7) (Protein p16.7)

1ZAE; 2BNK; 2C5R

FIB12_BPPH2 Pre-neck appendage protein (Gene product 12) (gp12) (NP1) (Protein p12) [Cleaved into: gp12*]

3GQ7; 3GQ8; 3GQ9; 3GQA; 3GQH; 3GQK; 3SUC; 6QZ9; 6QZF

CAPSF_BPPH2 Capsid fiber protein (Gene product 8.5) (gp8.5) (Head fiber protein) (Protein p8.5)

3QC7; 6QVK; 6QYD; 6QYY; 6QZ0

TF4_BPPH2 Late genes activator p4 (Gene product 4) (gp4) (Protein p4)

2FIO; 2FIP

PORTL_BPPH2 Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail ...

1FOU; 1H5W; 1IJG; 1JNB; 6QX7; 6QYJ; 6QYM; 6QZ9; 6QZF

SCAF_BPPH2 Capsid assembly scaffolding protein (Gene product 7) (gp7) (Head morphogenesis protein) (Protein p7) ...

1NO4; 1NOH; 3MTU; 3OA7; 4IFF; 4XA1; 4XA3; 4XA6; 5CJ1; 5WJB; 5WLQ; 5WME; 6PFP; 6YJD; 8F2M

GP13_BPPH2 Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13) [Includes: Lysozyme-like glycosidase ...

3CSQ; 3CSR; 3CSZ; 3CT0; 3CT1; 3CT5

GP17_BPPH2 DNA replication protein 17 (Gene product 17) (gp17) (Protein p17)

DIT9_BPPH2 Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

5FB4; 5FB5; 5FEI

ENLYS_BPPH2 Endolysin (EC 3.2.1.17) (Lysis protein) (Lysozyme) (Muramidase) (Protein p15)

HOLIN_BPPH2 Antiholin (Gene product 14) (gp14) (Lysis inhibitor 14-131) (Protein p14) [Includes: Holin (Lysis ...

CAPSD_BPPH2 Major capsid protein (Gene product 8) (gp8) (Major head protein) (Protein p8)

6QVK; 6QYD; 6QZ0; 8F2M; 8F2N; 8F2O

TUB11_BPPH2 Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

6QZ9; 6QZF

SSB_BPPH2 Single-stranded DNA-binding protein (SSB) (Gene product 5) (gp5) (Protein p5)

GP55_BPPH2 Gene product 5.5 (gp5.5) (Gene product 5B) (gp5B) (Protein p5.5)

P56_BPPH2 Protein p56

2LE2; 3ZOQ

GP166_BPPH2 Gene product 16.6 (gp16.6) (Protein p16.6)

GP168_BPPH2 Gene product 16.8 (gp16.8) (Protein p16.8)

GP169_BPPH2 Gene product 16.9 (gp16.9) (Protein p16.9)

4 entries

Bacillus phage Nf (Bacteriophage Nf) reference strain

DPOL_BPNF DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 2) (gp2) (Protein p2)

NP_BPNF Double-stranded DNA-binding protein (Gene product 6) (gp6) (Nucleoid-associated protein p6) (Protein ...

DIT9_BPNF Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9) (Tail protein)

SSB_BPNF Single-stranded DNA-binding protein (SSB) (Gene product 5) (gp5) (Protein p5)

26 entries

Bacillus phage PZA (Bacteriophage PZA)

DPOL_BPPZA DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 2) (gp2) (Protein p2)

TERM_BPPZA DNA terminal protein (Gene product 3) (gp3) (Protein p3)

NP_BPPZA Histone-like protein p6 (Double-stranded DNA-binding protein) (Double-stranded DNA-binding protein ...

PORTL_BPPZA Portal protein (Connector protein) (Gene product 10) (gp10) (Gene product 19) (gp19) (Head-to-tail ...

FIB12_BPPZA Preneck appendage protein (Gene product 12) (gp12) (Protein p12) [Cleaved into: gp12*]

GP13_BPPZA Morphogenesis protein 1 (Gene product 13) (gp13) (Protein p13) [Includes: Lysozyme-like glycosidase ...

HOLIN_BPPZA Antiholin (Gene product 14) (gp14) (Lysis inhibitor 14-131) (Protein p14) [Includes: Holin (Lysis ...

ENLYS_BPPZA Endolysin (EC 3.2.1.17) (Lysis protein) (Lysozyme) (Muramidase) (Protein p15)

GP167_BPPZA DNA replication protein 16.7 (Gene product 16.7) (gp16.7) (Protein p16.7)

P56_BPPZA Protein p56

4L5N

GP1_BPPZA DNA replication protein 1 (Gene product 1C) (gp1C)

TF4_BPPZA Late genes activator p4 (Gene product 4) (gp4) (Protein p4)

SSB_BPPZA Single-stranded DNA-binding protein (SSB) (Gene product 5) (gp5) (Protein p5)

CAPSD_BPPZA Major capsid protein (Gene product 8) (gp8) (Major head protein) (Protein p8)

CAPSF_BPPZA Capsid fiber protein (Gene product 8.5) (gp8.5) (Head fiber protein) (Protein p8.5)

SCAF_BPPZA Capsid assembly scaffolding protein (Gene product 7) (gp7) (Head morphogenesis protein) (Protein p7) ...

DIT9_BPPZA Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

PKG16_BPPZA DNA packaging protein (ATPase gp16) (EC 3.6.4.-) (Gene product 16) (gp16) (Protein p16)

GP17_BPPZA DNA replication protein 17 (Gene product 17) (gp17) (Protein p17)

TUB11_BPPZA Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

VG1A_BPPZA Early protein GP1A

GP55_BPPZA Gene product 5B (gp5B) (Protein p5B)

GP166_BPPZA Gene product 16.6 (gp16.6) (Protein p16.6)

GP165_BPPZA Gene product 16.5 (gp16.5) (Early protein GP16.5) (Protein p16.5)

GP168_BPPZA Gene product 16.8 (gp16.8) (Protein p16.8)

GP169_BPPZA Gene product 16.9 (gp16.9) (Protein p16.9)

1 entry

Bacillus phage phi29 (Bacteriophage phi-29)

17 entries

Bacillus phage B103 (Bacteriophage B103)

DPOL_BPB03 DNA polymerase (EC 2.7.7.7) (EC 3.1.11.-) (Gene product 2) (gp2) (Protein p2)

TERM_BPB03 DNA terminal protein (Gene product 3) (gp3) (Protein p3)

NP_BPB03 Histone-like protein p6 (Double-stranded DNA-binding protein) (Double-stranded DNA-binding protein ...

FIB12_BPB03 Pre-neck appendage protein (Gene product 12) (gp12) (Late protein GP12) (NP1) (Protein p12)

VG13_BPB03 Morphogenesis protein 1 (Late protein GP13) [Includes: Lysozyme-like glycosidase (EC 3.2.1.-); ...

HOLIN_BPB03 Antiholin (Gene product 14) (gp14) (Protein p14) [Includes: Holin]

ENLYS_BPB03 Endolysin (EC 3.2.1.17) (Lysis protein) (Lysozyme) (Muramidase) (Protein p15)

VG4_BPB03 Late genes activator (Early protein GP4)

SSB_BPB03 Single-stranded DNA-binding protein (SSB) (Gene product 5) (gp5) (Protein p5)

SCAF_BPB03 Capsid assembly scaffolding protein (Gene product 7) (gp7) (Head morphogenesis protein) (Protein p7) ...

CAPSD_BPB03 Major capsid protein (Gene product 8) (gp8) (Major head protein) (Protein p8)

CAPSF_BPB03 Capsid fiber protein (Gene product 8.5) (gp8.5) (Head fiber protein) (Protein p8.5)

DIT9_BPB03 Tail knob protein gp9 (Distal tube protein) (Gene product 9) (gp9) (Protein p9)

PORTL_BPB03 Portal protein (Gene product 10) (gp10) (Head-to-tail connector) (Upper collar protein)

TUB11_BPB03 Proximal tail tube connector protein (Gene product 11) (gp11) (Lower collar protein) (Protein p11)

PKG16_BPB03 DNA packaging protein (ATPase gp16) (EC 3.6.4.-) (Gene product 16) (gp16) (Protein p16)

VG17_BPB03 Early protein GP17

3 entries

Bacillus phage Nf (Bacteriophage Nf)

TERM_BPNF DNA terminal protein (Gene product 3) (gp3) (Protein p3)

VG4_BPNF Late genes activator (Early protein GP4) (GPF)

VG85_BPNF Head fiber protein (Late protein GP8.5)

6 entries

Bacillus phage phi15 (Bacteriophage phi-15)

GP167_BPPH5 DNA replication protein 16.7 (Gene product 16.7) (gp16.7) (Protein p16.7)

GP17_BPPH5 DNA replication protein 17 (Gene product 17) (gp17) (Protein p17)

GP166_BPPH5 Gene product 16.6 (gp16.6) (Protein p16.6)

GP165_BPPH5 Gene product 16.5 (gp16.5) (Early protein GP16.5) (Protein p16.5)

GP168_BPPH5 Gene product 16.8 (gp16.8) (Protein p16.8)

GP169_BPPH5 Gene product 16.9 (gp16.9) (Protein p16.9)