Mimoreovirus (taxid:699182)

VIRION

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Non enveloped, icosahedral, non-turreted virion with a triple capsid structure, about 90-95 nm in diameter. The intermediate capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.

GENOME

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Segmented linear dsRNA genome. Contains 11 segments encoding for at least 11 proteins. Segment 1 of MpRV is 5.8 kb long, the longest segment of any of the characterized reoviruses.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

11 entries grouped by protein

1 entry

Major inner capsid protein VP3

CAPSD_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Putative non-structural protein 1 (NS1)

NS1_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Putative non-structural protein 2 (NS2)

NS2_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

RNA-directed RNA polymerase VP2 (EC 2.7.7.48)

RDRP_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Uncharacterized protein VP1

VP1_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Uncharacterized protein VP10

VP10_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Uncharacterized protein VP11

VP11_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Uncharacterized protein VP4

VP4_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Putative outer capsid protein VP5

VP5_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Uncharacterized protein VP6

VP6_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain

1 entry

Putative outer capsid protein VP9

VP9_MPRVN
Micromonas pusilla reovirus (isolate Netherlands/2005) (MpRV) reference strain