Dinovernavirus (taxid:699180)

VIRION

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Non enveloped, turreted virion with a T=2* icosahedral symmetry, about 49-50 nm in diameter. The capsid is composed of only a single shell of protein.
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GENOME

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Segmented linear dsRNA genome. Contains 9 segments encoding for at least 9 proteins.

GENE EXPRESSION

The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a capped mRNA from each dsRNA segment. This capped mRNA is translocated to the cell cytoplasm where it is translated.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Full-length plus-strand transcripts from each of the dsRNA segments are synthesized. These plus-strand transcripts are used as templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

9 entries grouped by protein

1 entry

Putative major capsid protein VP3

CAPSD_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

RNA-directed RNA polymerase VP2 (EC 2.7.7.48)

RDRP_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Putative structural protein VP1

VP1_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Putative non-structural protein 4 (NS4)

VP4_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Outer capsid protein VP5

VP5_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Microtubule-associated protein VP6

VP6_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Uncharacterized protein VP7

VP7_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Uncharacterized protein VP8

VP8_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

1 entry

Uncharacterized protein VP9

VP9_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain